| Identification |
|---|
| HMDB Protein ID
| CDBP04050 |
| Secondary Accession Numbers
| Not Available |
| Name
| Telomerase-binding protein EST1A |
| Description
| Not Available |
| Synonyms
|
- EST1-like protein A
- Ever shorter telomeres 1A
- Smg-6 homolog
- Telomerase subunit EST1A
- hSmg5/7a
|
| Gene Name
| SMG6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Dephosphorylates RENT1. Plays a role in nonsense-mediated mRNA decay. May function as endonuclease. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- nucleolus
- Chromosome
- telomere (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17p13.3 |
| SNPs
| SMG6 |
| Gene Sequence
|
>4260 bp
ATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCGGAGCTGCGCGGGATCCTGGCT
ACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCG
CGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGG
AACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAAT
GACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAA
CTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCC
TTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAA
CCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCC
AGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGAT
GAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATA
GAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATG
GGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCC
GCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGC
TCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGC
CGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCA
ACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGT
TCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAA
AACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAAC
AAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAA
GGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAA
CTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAAT
TCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGT
AAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAAT
CCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGAT
GATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAG
TTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTAT
CCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCA
GGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCT
ACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAG
CTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCC
AGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTG
CAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGAT
CAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAG
GATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAG
GGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTG
GAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATAT
GCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAG
CAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCAC
ATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGG
AGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTG
ACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATG
GAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAG
TCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCC
CATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTG
GGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCAT
GGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTC
AAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTG
CAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGACTGCTTCTCG
GAGGAGTGCCGCTCTGTGATCCAGGAACAAGCCGCAGCTCTGGGCTTGGCCATGTTTTCT
CTACTGGTCCGCCGCTGCACCTGCTTACTTAAGGAGTCCGCCAAAGCTCAGCTGTCCTCT
CCTGAGGACCAGGATGACCAAGACGACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAAG
GAGCTGCTCCCCAGTGTCAAAGTCTGGTCAGATTGGATGCTCGGCTACCCGGACACCTGG
AATCCTCCTCCCACATCCCTGGATCTGCCCTCGCATGTTGCTGTGGATGTATGGTCGACG
CTGGCTGATTTCTGTAACATACTGACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAAG
GACCCGGATGATGACCTCACCCTTCTTATCCTGGAAGAGGATCGGCTTCTCTCGGGCTTT
GTCCCCTTGCTGGCTGCCCCTCAGGACCCCTGCTACGTGGAGAAAACCTCGGATAAGGTT
ATTGCAGCTGACTGCAAAAGGGTCACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGA
CAAGAAGAGCCTCTGCTGGCATTCAAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCA
GACACCATGGGAAAGGAAATGGGAAGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAG
GATGTGGTGATTGAAGACTTTGAGGAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGAT
GACATCAGGGAGCTTCGGGCCAAGAAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAG
CGTCGCCAGGAAAAGATCCAGGCTGTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAG
CTCGAAATCAGACCTTTGTTCCTCGTACCAGACACCAACGGCTTCATTGACCACCTGGCC
AGTCTGGCGCGGCTGCTGGAGAGCAGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATC
AATGAGCTGGACGGCCTGGCCAAGGGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCC
CGTGTGGTACAAGAGAAGGCCCGCAAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGT
CGGGACTCTTGCCTGCGAGCCCTGACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTC
CGCAGTGAGGACATCACTGGCCAGCTGGGTAACAACGATGATCTCATCCTGTCCTGCTGC
CTCCACTACTGCAAAGACAAGGCTAAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATC
CGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTC
ACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1419 |
| Molecular Weight
| 160460.3 |
| Theoretical pI
| 7.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Telomerase-binding protein EST1A
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR
NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES
FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS
AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS
TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN
SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD
DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS
RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK
DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR
RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK
STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS
EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK
ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK
DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG
QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED
DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA
SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES
RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI
RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
|
| External Links |
|---|
| GenBank ID Protein
| 115511020 |
| UniProtKB/Swiss-Prot ID
| Q86US8 |
| UniProtKB/Swiss-Prot Entry Name
| EST1A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_017575.4 |
| GeneCard ID
| SMG6 |
| GenAtlas ID
| SMG6 |
| HGNC ID
| HGNC:17809 |
| References |
|---|
| General References
| Not Available |