Showing Protein Dual specificity protein phosphatase 18 (CDBP04048)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP04048
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 18
Description Not Available
Synonyms
  1. LMW-DSP20
  2. Low molecular weight dual specificity phosphatase 20
Gene Name DUSP18
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
GO Classification
Cellular Component
cytoplasm
nucleus
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
map kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 22
Locus 22q12.2
SNPs DUSP18
Gene Sequence 
>567 bp
ATGGCAGCACCCTCGTGTGCCTTCCCAGTTCAGTTCCGGCAGCCCTCAGTCAGCGGCCTC
TCGCAGATAACCAAAAGCCTGTATATCAGCAATGGTGTGGCCGCCAACAACAAGCTCATG
CTGTCTAGCAACCAGATCACCATGGTCATCAATGTCTCAGTGGAGGTAGTGAACACCTTG
TATGAGGATATCCAGTACATGCAGGTACCTGTGGCTGACTCCCCTAACTCACGTCTCTGT
GACTTCTTTGACCCTATTGCTGACCATATCCACAGCGTGGAGATGAAGCAGGGCCGTACT
TTGCTGCACTGTGCTGCTGGTGTGAGCCGCTCAGCTGCCCTGTGCCTCGCCTACCTCATG
AAGTACCACGCCATGTCCCTGCTGGACGCCCACACGTGGACCAAGTCATGCCGGCCCATC
ATCCGACCCAACAGCGGCTTTTGGGAGCAGCTCATCCACTATGAGTTCCAATTGTTTGGC
AAGAACACTGTGCACATGGTCAGTTCCCCAGTGGGAATGATCCCTGACATCTATGAGAAG
GAAGTCCGTTTGATGATTCCACTGTGA
Protein Properties
Number of Residues 188
Molecular Weight 21066.315
Theoretical pI 7.468
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dual specificity protein phosphatase 18
MTAPSCAFPVQFRQPSVSGLSQITKSLYISNGVAANNKLMLSSNQITMVINVSVEVVNTL
YEDIQYMQVPVADSPNSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLM
KYHAMSLLDAHTWTKSCRPIIRPNSGFWEQLIHYEFQLFGKNTVHMVSSPVGMIPDIYEK
EVRLMIPL
GenBank ID Protein 26050104
UniProtKB/Swiss-Prot ID Q8NEJ0
UniProtKB/Swiss-Prot Entry Name DUS18_HUMAN
PDB IDs
GenBank Gene ID AF461689
GeneCard ID DUSP18
GenAtlas ID DUSP18
HGNC ID HGNC:18484
References
General References Not Available