| Identification |
|---|
| HMDB Protein ID
| CDBP04041 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin-like domain-containing CTD phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- Nuclear proteasome inhibitor UBLCP1
|
| Gene Name
| UBLCP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphoprotein phosphatase activity |
| Specific Function
| Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
|
| GO Classification
|
| Cellular Component |
| nucleolus |
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| phosphoprotein phosphatase activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q33.3 |
| SNPs
| UBLCP1 |
| Gene Sequence
|
>957 bp
ATGGCTCTCCCTATCATTGTAAAATGGGGTGGACAGGAGTATTCAGTGACCACACTTTCA
GAAGATGATACTGTGCTCGATCTCAAACAGTTTCTCAAGACCCTTACAGGAGTTCTTCCA
GAACGCCAAAAGTTACTTGGACTCAAAGTTAAAGGCAAACCTGCAGAAAATGATGTTAAG
CTTGGAGCTCTCAAACTGAAACCAAATACTAAAATCATGATGATGGGAACTCGTGAGGAG
AGCTTGGGAGATGTCTTAGGTCCACCCCCTGACAATGATGATGTTGTTAATGACTTTGAT
ATTGAAGATGAAGTAGTTGAAGTAGAAAATAGGGAAGAAAACCTACTGAAAATTTCTCGC
AGAGTGAAAGAGTACAAAGTGGAAATTTTGAATCCTCCCAGGGAAGGGAAAAAGCTTTTG
GTGCTAGATGTTGATTATACATTATTTGACCACAGGTCTTGTGCAGAGACTGGGGTAGAA
TTAATGCGGCCATATCTTCATGAATTTCTAACATCTGCCTATGAAGATTATGACATTGTT
ATTTGGTCTGCAACAAATATGAAGTGGATTGAAGCTAAAATGAAAGAGCTGGGAGTGAGC
ACAAATGCAAATTATAAGATTACTTTCATGTTGGATAGTGCTGCTATGATAACAGTACAT
ACTCCAAGGAGAGGATTAATAGACGTAAAGCCTCTTGGTGTTATATGGGGAAAGTTTTCG
GAGTTTTACAGCAAGAAAAACACCATTATGTTTGATGACATAGGGAGAAATTTTCTAATG
AACCCACAGAATGGACTAAAGATAAGGCCTTTTATGAAAGCGCACCTAAATCGTGATAAA
GACAAAGAACTTTTAAAATTAACTCAGTACCTCAAGGAGATAGCAAAATTAGATGACTTT
TTGGATCTAAATCACAAATATTGGGAAAGATATCTCTCAAAGAAGCAAGGACAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 318 |
| Molecular Weight
| 36804.355 |
| Theoretical pI
| 6.461 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-like domain-containing CTD phosphatase 1
MALPIIVKWGGQEYSVTTLSEDDTVLDLKQFLKTLTGVLPERQKLLGLKVKGKPAENDVK
LGALKLKPNTKIMMMGTREESLEDVLGPPPDNDDVVNDFDIEDEVVEVENREENLLKISR
RVKEYKVEILNPPREGKKLLVLDVDYTLFDHRSCAETGVELMRPYLHEFLTSAYEDYDIV
IWSATNMKWIEAKMKELGVSTNANYKITFMLDSAAMITVHTPRRGLIDVKPLGVIWGKFS
EFYSKKNTIMFDDIGRNFLMNPQNGLKIRPFMKAHLNRDKDKELLKLTQYLKEIAKLDDF
LDLNHKYWERYLSKKQGQ
|
| External Links |
|---|
| GenBank ID Protein
| 16553992 |
| UniProtKB/Swiss-Prot ID
| Q8WVY7 |
| UniProtKB/Swiss-Prot Entry Name
| UBCP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK057996 |
| GeneCard ID
| UBLCP1 |
| GenAtlas ID
| UBLCP1 |
| HGNC ID
| HGNC:28110 |
| References |
|---|
| General References
| Not Available |