| Identification |
|---|
| HMDB Protein ID
| CDBP04040 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tubulin--tyrosine ligase |
| Description
| Not Available |
| Synonyms
|
- TTL
|
| Gene Name
| TTL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin (By similarity).
|
| GO Classification
|
| Biological Process |
| regulation of axon extension |
| cellular protein modification process |
| microtubule cytoskeleton organization |
| Function |
| catalytic activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| tubulin-tyrosine ligase activity |
| Molecular Function |
| tubulin-tyrosine ligase activity |
| ATP binding |
| Process |
| metabolic process |
| macromolecule metabolic process |
| biopolymer metabolism |
| biopolymer modification |
| protein modification |
| physiological process |
| metabolism |
| macromolecule metabolism |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q13 |
| SNPs
| TTL |
| Gene Sequence
|
>1134 bp
ATGTACACCTTCGTGGTACGCGATGAGAACAGCAGCGTCTACGCCGAGGTCTCCCGGCTG
CTCCTCGCCACCGGCCACTGGAAGAGGCTGCGGCGAGACAACCCCAGATTCAACCTGATG
CTGGGAGAGAGGAATCGGCTGCCCTTCGGGAGACTGGGTCACGAGCCCGGGCTGGTACAG
TTGGTGAATTACTACAGGGGTGCTGACAAACTGTGTCGCAAAGCTTCTTTAGTGAAGCTA
ATCAAGACAAGCCCTGAACTGGCTGAGTCCTGCACATGGTTCCCTGAATCTTATGTGATT
TATCCAACCAATCTCAAGACTCCAGTTGCTCCAGCACAGAATGGAATTCAGCCACCAATC
AGTAACTCAAGGACAGATGAAAGAGAATTCTTTCTCGCCTCTTATAACAGAAAGAAAGAG
GATGGAGAGGGCAACGTTTGGATTGCAAAGTCATCAGCCGGTGCCAAAGGTGAAGGCATT
CTCATCTCCTCAGAGGCTTCAGAGCTTCTCGATTTCATAGACAACCAGGGCCAAGTGCAC
GTGATCCAGAAATATCTTGAGCACCCTCTGCTGCTTGAGCCAGGTCATCGCAAGTTTGAC
ATCCGAAGCTGGGTCTTGGTGGATCATCAGTATAATATCTACCTCTATAGAGAGGGTGTG
CTTCGGACTGCTTCAGAACCATATCATGTTGATAATTTCCAAGACAAAACCTGCCATTTG
ACCAATCACTGCATTCAAAAAGAGTATTCAAAGAACTACGGGAAGTATGAAGAAGGAAAT
GAAATGTTCTTCAAGGAGTTCAATCAGTACCTAACAAGTGCTTTGAACATTACCCTAGAA
AGTAGTATCTTACTACAAATCAAACATATAATAAGGAACTGCCTCCTGAGCGTGGAGCCT
GCCATTAGCACCAAGCACCTCCCTTACCAGAGCTTCCAGCTCTTCGGCTTTGACTTCATG
GTCGATGAGGAGCTGAAGGTGTGGCTCATTGAGGTCAACGGTGCCCCTGCATGTGCTCAG
AAGCTCTATGCAGAACTGTGCCAAGGCATCGTGGACATAGCCATTTCCAGTGTCTTCCCA
CCCCCAGATGTGGAGCAACCTCAGACCCAGCCAGCTGCCTTCATCAAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 43211.94 |
| Theoretical pI
| 6.744 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tubulin--tyrosine ligase
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQ
LVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPI
SNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVH
VIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHL
TNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEP
AISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFP
PPDVEQPQTQPAAFIKL
|
| External Links |
|---|
| GenBank ID Protein
| 40363527 |
| UniProtKB/Swiss-Prot ID
| Q8NG68 |
| UniProtKB/Swiss-Prot Entry Name
| TTL_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB071393 |
| GeneCard ID
| TTL |
| GenAtlas ID
| TTL |
| HGNC ID
| HGNC:21586 |
| References |
|---|
| General References
| Not Available |