Showing Protein CCA tRNA nucleotidyltransferase 1, mitochondrial (CDBP04038)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 4 compounds
Identification
HMDB Protein ID CDBP04038
Secondary Accession Numbers Not Available
Name CCA tRNA nucleotidyltransferase 1, mitochondrial
Description Not Available
Synonyms
  1. Mitochondrial tRNA nucleotidyl transferase, CCA-adding
  2. mt CCA-adding enzyme
  3. mt tRNA CCA-diphosphorylase
  4. mt tRNA CCA-pyrophosphorylase
  5. mt tRNA adenylyltransferase
Gene Name TRNT1
Protein Type Enzyme
Biological Properties
General Function Involved in RNA binding
Specific Function Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. Isoform 2: Adds 2 C residues (CC-) to the 3' terminus of tRNA molecules instead of a complete CCA end as isoform 1 does (in vitro).
GO Classification
Biological Process
tRNA 3'-end processing
tRNA 3'-terminal CCA addition
protein targeting to mitochondrion
Cellular Component
mitochondrion
centrosome
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
nucleic acid binding
rna binding
Molecular Function
ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
CTP:3'-cytidine-tRNA cytidylyltransferase activity
CTP:tRNA cytidylyltransferase activity
tRNA adenylyltransferase activity
tRNA nucleotidyltransferase activity
ATP binding
tRNA binding
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
rna metabolic process
Cellular Location
  1. Mitochondrion
Pathways
Gene Properties
Chromosome Location 3
Locus 3p25.1
SNPs TRNT1
Gene Sequence 
>1305 bp
ATGCTGAGGTGCCTGTATCATTGGCACAGGCCAGTGCTGAACCGTAGGTGGAGTAGGCTG
TGCCTTCTGAAGCAGTATCTATTCACAATGAAGTTGCAGTCTCCCGAATTCCAGTCACTT
TTCACAGAAGGACTGAAGAGTCTGACAGAATTATTTGTCAAAGAGAATCACGAATTAAGA
ATAGCAGGAGGAGCAGTGAGGGATTTATTAAATGGAGTAAAGCCTCAGGATATAGATTTT
GCCACCACTGCTACCCCTACTCAAATGAAGGAGATGTTTCAGTCGGCTGGGATTCGGATG
ATAAACAACAGAGGAGAAAAGCACGGAACAATTACTGCCAGGCTTCATGAAGAAAATTTT
GAGATTACTACACTACGGATTGATGTCACCACTGATGGAAGACATGCTGAGGTAGAATTT
ACAACTGACTGGCAGAAAGATGCGGAACGCAGAGATCTCACTATAAATTCTATGTTTTTA
GGTTTTGATGGCACTTTATTTGACTACTTTAATGGTTATGAAGATTTAAAAAATAAGAAA
GTTAGATTTGTTGGACATGCTAAACAGAGAATACAAGAGGATTATCTTAGAATTTTAAGA
TACTTCAGGTTTTATGGGAGAATTGTAGACAAACCTGGTGACCATGATCCTGAGACTTTG
GAAGCAATTGCAGAAAATGCAAAAGGCTTGGCTGGAATATCAGGAGAAAGGATTTGGGTG
GAACTGAAAAAAATTCTTGTTGGTAACCATGTAAATCATTTGATTCACCTTATCTATGAT
CTTGATGTGGCTCCTTATATAGGTTTACCTGCTAATGCAAGTTTAGAAGAATTTGACAAA
GTCAGTAAAAATGTTGATGGTTTTTCACCAAAGCCAGTGACTCTTTTGGCCTCATTATTC
AAAGTACAAGATGATGTCACAAAATTGGATTTGAGGTTGAAGATCGCGAAAGAGGAGAAA
AACCTTGGCTTATTTATAGTTAAAAATAGGAAAGATTTAATTAAAGCAACAGATAGTTCA
GACCCATTGAAACCCTATCAAGACTTCATTATAGATTCTAGGGAACCTGATGCAACTACT
CGTGTATGTGAACTACTGAAGTACCAAGGAGAGCACTGTCTCCTAAAGGAAATGCAGCAG
TGGTCCATTCCTCCATTTCCTGTAAGTGGCCATGACATCAGAAAAGTGGGCATTTCTTCA
GGAAAAGAAATTGGGGCTCTATTACAACAGTTGCGAGAACAGTGGAAAAAAAGTGGTTAC
CAAATGGAAAAAGATGAACTTCTGAGTTACATAAAGAAGACCTAA
Protein Properties
Number of Residues 434
Molecular Weight 50143.185
Theoretical pI 8.102
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>tRNA-nucleotidyltransferase 1, mitochondrial
MLRCLYHWHRPVLNRRWSRLCLPKQYLFTMKLQSPEFQSLFTEGLKSLTELFVKENHELR
IAGGAVRDLLNGVKPQDIDFATTATPTQMKEMFQSAGIRMINNRGEKHGTITARLHEENF
EITTLRIDVTTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFNGYEDLKNKK
VRFVGHAKQRIQEDYLRILRYFRFYGRIVDKPGDHDPETLEAIAENAKGLAGISGERIWV
ELKKILVGNHVNHLIHLIYDLDVAPYIGLPANASLEEFDKVSKNVDGFSPKPVTLLASLF
KVQDDVTKLDLRLKIAKEEKNLGLFIVKNRKDLIKATDSSDPLKPYQDFIIDSREPDATT
RVCELLKYQGEHCLLKEMQQWSIPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGY
QMEKDELLSYIKKT
GenBank ID Protein 16416451
UniProtKB/Swiss-Prot ID Q96Q11
UniProtKB/Swiss-Prot Entry Name TRNT1_HUMAN
PDB IDs
GenBank Gene ID AB063105
GeneCard ID TRNT1
GenAtlas ID TRNT1
HGNC ID HGNC:17341
References
General References Not Available