| Identification |
|---|
| HMDB Protein ID
| CDBP04036 |
| Secondary Accession Numbers
| Not Available |
| Name
| Three prime repair exonuclease 1 |
| Description
| Not Available |
| Synonyms
|
- 3'-5' exonuclease TREX1
- DNase III
|
| Gene Name
| TREX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleic acid binding |
| Specific Function
| Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair |
| GO Classification
|
| Function |
| binding |
| nucleic acid binding |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.31 |
| SNPs
| TREX1 |
| Gene Sequence
|
>1110 bp
ATGGGCCCTGGAGCTCGCAGACAGGGCAGGATTGTGCAGGGAAGGCCTGAGATGTGCTTC
TGCCCACCCCCTACCCCACTCCCTCCCCTTCGGATCTTAACACTGGGCACTCACACACCC
ACCCCATGCTCCTCTCCAGGCTCAGCAGCAGGTACGTACCCAACCATGGGCTCGCAGGCC
CTGCCCCCGGGGCCCATGCAGACCCTCATCTTTTTCGACATGGAGGCCACTGGCTTGCCC
TTCTCCCAGCCCAAGGTCACGGAGCTGTGCCTGCTGGCTGTCCACAGATGTGCCCTGGAG
AGCCCCCCCACCTCTCAGGGGCCACCTCCCACAGTTCCTCCACCACCGCGTGTGGTAGAC
AAGCTCTCCCTGTGTGTGGCTCCGGGGAAGGCCTGCAGCCCTGCAGCCAGCGAGATCACA
GGTCTGAGCACAGCTGTGCTGGCAGCGCATGGGCGTCAATGTTTTGATGACAACCTGGCC
AACCTGCTCCTAGCCTTCCTGCGGCGCCAGCCACAGCCCTGGTGCCTGGTGGCACACAAT
GGTGACCGCTACGACTTCCCCCTGCTCCAAGCAGAGCTGGCTATGCTGGGCCTCACCAGT
GCTCTGGATGGTGCCTTCTGTGTGGATAGCATCACTGCGCTGAAGGCCCTGGAGCGAGCA
AGCAGCCCCTCAGAACACGGCCCAAGGAAGAGCTACAGCCTAGGCAGCATCTACACTCGC
CTGTATGGGCAGTCCCCTCCAGACTCGCACACGGCTGAGGGTGATGTCCTGGCCCTGCTC
AGCATCTGTCAGTGGAGACCACAGGCCCTGCTGCGGTGGGTGGATGCTCACGCCAGGCCT
TTCGGCACCATCAGGCCCATGTATGGGGTCACAGCCTCTGCTAGGACCAAGCCAAGACCA
TCTGCTGTCACAACCACTGCACACCTGGCCACAACCAGGAACACTAGTCCCAGCCTTGGA
GAGAGCAGGGGTACCAAGGATCTTCCTCCAGTGAAGGACCCTGGAGCCCTATCCAGGGAG
GGGCTGCTGGCCCCACTGGGTCTGCTGGCCATCCTGACCTTGGCAGTAGCCACACTGTAT
GGACTATCCCTGGCCACACCTGGGGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 369 |
| Molecular Weight
| 38922.5 |
| Theoretical pI
| 8.49 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Three prime repair exonuclease 1
MGPGARRQGRIVQGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGTYPTMGSQA
LPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVD
KLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHN
GDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTR
LYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRP
SAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLY
GLSLATPGE
|
| External Links |
|---|
| GenBank ID Protein
| 7705353 |
| UniProtKB/Swiss-Prot ID
| Q9NSU2 |
| UniProtKB/Swiss-Prot Entry Name
| TREX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016381.3 |
| GeneCard ID
| TREX1 |
| GenAtlas ID
| TREX1 |
| HGNC ID
| HGNC:12269 |
| References |
|---|
| General References
| Not Available |