| Identification |
|---|
| HMDB Protein ID
| CDBP04033 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3'-5' exoribonuclease 1 |
| Description
| Not Available |
| Synonyms
|
- 3'-5' exonuclease ERI1
- Eri-1 homolog
- HEXO
- Histone mRNA 3'-end-specific exoribonuclease
- Histone mRNA 3'-exonuclease 1
- Protein 3'hExo
|
| Gene Name
| ERI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in exonuclease activity |
| Specific Function
| RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| exonuclease activity |
| nucleic acid binding |
| nuclease activity |
|
| Cellular Location
|
- Nucleus
- Nucleus
- Cytoplasm
- nucleolus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p23.1 |
| SNPs
| ERI1 |
| Gene Sequence
|
>1050 bp
ATGGAGGATCCACAGAGTAAAGAGCCTGCCGGCGAGGCCGTGGCTCTCGCGCTGCTGGAG
TCGCCGCGGCCGGAGGGCGGGGAGGAGCCGCCGCGTCCCAGTCCCGAGGAAACTCAACAG
TGTAAATTTGATGGCCAGGAGACAAAAGGATCCAAGTTCATTACCTCCAGTGCGAGTGAC
TTCAGTGACCCGGTTTACAAAGAGATTGCCATTACGAATGGCTGTATTAATAGAATGAGT
AAGGAAGAACTCAGAGCTAAGCTTTCAGAATTCAAGCTTGAAACTAGAGGAGTAAAGGAT
GTTCTAAAGAAGAGACTGAAAAACTATTATAAGAAGCAGAAGCTGATGCTGAAAGAGAGC
AATTTTGCTGACAGTTATTATGACTACATTTGTATTATTGACTTTGAAGCCACTTGTGAA
GAAGGAAACCCACCTGAGTTTGTACATGAAATAATTGAATTTCCGGTTGTTTTACTGAAT
ACGCATACTTTAGAAATAGAAGACACGTTTCAGCAGTATGTAAGACCAGAGATTAACACA
CAGCTGTCTGATTTCTGCATCAGTCTAACTGGAATTACTCAGGATCAGGTAGACAGAGCT
GATACCTTCCCTCAGGTACTAAAAAAAGTAATTGACTGGATGAAATTGAAGGAATTAGGA
ACAAAGTATAAATACTCACTTTTAACAGATGGTTCTTGGGATATGAGTAAGTTCTTGAAC
ATTCAGTGTCAACTCAGCAGGCTCAAATACCCTCCTTTTGCGAAAAAGTGGATCAATATT
CGGAAGTCATATGGAAATTTTTACAAGGTTCCTAGAAGCCAAACCAAACTGACAATAATG
CTTGAAAAATTAGGAATGGATTATGATGGGCGGCCTCACTGTGGTCTTGATGACTCTAAG
AATATCGCCCGAATAGCAGTTCGAATGCTTCAGGATGGGTGTGAACTCCGAATCAACGAG
AAAATGCATGCAGGACAGCTAATGAGTGTGTCCTCTTCCTTACCAATAGAGGGCACTCCA
CCACCACAAATGCCACATTTTAGAAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 349 |
| Molecular Weight
| 40063.6 |
| Theoretical pI
| 6.67 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>3'-5' exoribonuclease 1
MEDPQSKEPAGEAVALALLESPRPEGGEEPPRPSPEETQQCKFDGQETKGSKFITSSASD
FSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKES
NFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQYVRPEINT
QLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTKYKYSLLTDGSWDMSKFLN
IQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHCGLDDSK
NIARIAVRMLQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFRK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8IV48 |
| UniProtKB/Swiss-Prot Entry Name
| ERI1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY310909 |
| GeneCard ID
| ERI1 |
| GenAtlas ID
| ERI1 |
| HGNC ID
| HGNC:23994 |
| References |
|---|
| General References
| Not Available |