| Identification |
|---|
| HMDB Protein ID
| CDBP04032 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity testis-specific protein kinase 1 |
| Description
| Not Available |
| Synonyms
|
- Testicular protein kinase 1
|
| Gene Name
| TESK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis |
| GO Classification
|
| Function |
| protein tyrosine kinase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p13 |
| SNPs
| TESK1 |
| Gene Sequence
|
>1881 bp
ATGGCCGGGGAACGGCCCCCACTGCGGGGCCCTGGGCCCGGGCCTGGAGAGGTGCCGGGG
GAGGGGCCCCCGGGGCCGGGGGGCACGGGCGGAGGCCCGGGCCGGGGCCGCCCCTCCTCC
TACCGGGCTCTCCGCAGCGCCGTGTCTAGCCTGGCGCGTGTGGACGATTTTCACTGCGCG
GAGAAGATCGGGGCCGGCTTCTTCTCTGAGGTCTACAAGGTTCGGCACCGACAGTCAGGG
CAAGTCATGGTGCTGAAGATGAACAAGCTCCCCAGTAACCGGGGCAACACACTACGGGAA
GTGCAGCTGATGAACCGGCTCAGGCACCCCAACATCCTAAGGTTCATGGGAGTCTGTGTG
CACCAGGGACAGCTGCACGCTCTTACAGAGTATATGAATGGGGGGACATTGGAACAGCTG
CTCAGCTCCCCTGAACCCCTGTCCTGGCCGGTCAGGCTCCACCTGGCCCTGGACATTGCC
CGAGGCCTGCGGTACCTGCACTCCAAAGGTGTATTTCACCGCGACCTCACATCCAAGAAC
TGTCTAGTCCGACGGGAAGATCGAGGCTTCACCGCTGTCGTGGGTGACTTCGGGCTGGCC
GAAAAGATTCCTGTGTATAGGGAGGGGGCAAGGAAGGAGCCATTGGCCGTGGTGGGCTCC
CCATACTGGATGGCTCCAGAGGTGTTACGGGGTGAGCTGTATGATGAGAAGGCTGATGTC
TTTGCCTTCGGGATTGTCCTCTGTGAGCTCATCGCCCGAGTACCTGCAGACCCTGACTAC
CTACCACGCACTGAGGACTTTGGCCTGGATGTGCCTGCTTTCCGAACTCTGGTGGGGGAT
GACTGCCCACTGCCTTTCTTGCTCCTGGCCATCCACTGCTGCAACCTGGAACCCAGCACC
CGTGCCCCCTTCACCGAAATTACCCAGCACCTGGAATGGATCCTGGAGCAGCTGCCTGAG
CCAGCCCCACTCACCAGGACCGCCCTGACACACAATCAGGGCTCTGTTGCAAGAGGGGGT
CCCTCTGCCACGCTTCCCAGGCCAGATCCCCGGCTTTCCCGAAGCCGGTCAGACCTCTTC
CTGCCCCCATCACCAGAATCACCCCCCAACTGGGGGGACAATCTGACTCGAGTCAACCCC
TTCTCACTACGGGAAGACCTCAGGGGTGGCAAGATCAAGCTCTTAGACACACCCAGCAAG
CCAGTCCTGCCTCTTGTGCCACCATCACCATTCCCATCCACTCAGCTGCCCTTGGTGACC
ACTCCGGAGACCCTGGTCCAGCCTGGGACACCTGCCCGCCGCTGCCGCTCACTACCCTCA
TCCCCCGAGCTCCCCCGCCGTATGGAGACAGCACTGCCAGGTCCTGGCCCTCCCGCTGTG
GGCCCCTCGGCTGAAGAGAAGATGGAGTGCGAGGGCAGCAGCCCTGAGCCGGAACCTCCA
GGGCCAGCGCCCCAGCTGCCTCTGGCTGTGGCCACAGACAACTTCATCAGCACCTGTTCC
TCGGCCTCCCAACCCTGGTCCCCTAGATCAGGACCCGTCCTCAATAACAATCCCCCAGCT
GTGGTGGTGAACTCCCCACAAGGCTGGGCTGGGGAGCCCTGGAACCGGGCCCAGCATAGC
CTGCCCCGGGCGGCAGCCCTGGAGCGGACAGAACCCTCGCCACCCCCTTCAGCTCCCCGG
GAGCCCGATGAGGGGCTGCCCTGTCCTGGCTGCTGCCTCGGCCCCTTCAGCTTTGGCTTC
CTGTCCATGTGCCCCCGCCCCACACCAGCTGTTGCCCGCTACCGCAACCTGAACTGTGAG
GCGGGCAGTCTCCTCTGCCACCGAGGGCACCACGCCAAGCCACCCACACCCAGCCTGCAG
CTGCCTGGGGCACGCTCTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 626 |
| Molecular Weight
| 67683.7 |
| Theoretical pI
| 8.15 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dual specificity testis-specific protein kinase 1
MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA
EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV
HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN
CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV
FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST
RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF
LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT
TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP
GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS
LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE
AGSLLCHRGHHAKPPTPSLQLPGARS
|
| External Links |
|---|
| GenBank ID Protein
| 55958923 |
| UniProtKB/Swiss-Prot ID
| Q15569 |
| UniProtKB/Swiss-Prot Entry Name
| TESK1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL357874 |
| GeneCard ID
| TESK1 |
| GenAtlas ID
| TESK1 |
| HGNC ID
| HGNC:11731 |
| References |
|---|
| General References
| Not Available |