Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase TAO2 (CDBP04031)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04031

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase TAO2

Description

Not Available

Synonyms

Kinase from chicken homolog C
PSK-1
Prostate-derived STE20-like kinase 1
Thousand and one amino acid protein 2
hKFC-C

Gene Name

TAOK2

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1, but not isoform 2, activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3 and MKK6 kinases. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7- mediated activation of IKKA, and thus NF-kappa-B activation, but not that of JNK. Phosphorylates itself, MBP, activated MAPK8 and tubulins. May play a role in the osmotic stress-MAPK8 pathway

GO Classification

Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
Process
protein amino acid phosphorylation
phosphorylation
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process

Cellular Location

Nucleus
Cytoplasm
Multi-pass membrane protein (Potential)
cytoskeleton
Cytoplasmic vesicle membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

16p11.2

SNPs

TAOK2

Gene Sequence

>3708 bp
ATGCCAGCTGGGGGCCGGGCCGGGAGCCTGAAGGACCCAGATGTGGCTGAGCTCTTCTTC
AAGGATGACCCAGAAAAGCTCTTCTCTGACCTCCGGGAAATTGGCCATGGCAGCTTTGGA
GCCGTATACTTTGCCCGGGATGTCCGGAATAGTGAGGTGGTGGCCATCAAGAAGATGTCC
TACAGTGGGAAGCAGTCCAATGAGAAATGGCAAGACATCATCAAGGAGGTGCGGTTCTTA
CAGAAGCTCCGGCATCCCAACACCATTCAGTACCGGGGCTGTTACCTGAGGGAGCACACG
GCTTGGCTGGTAATGGAGTATTGCCTGGGCTCAGCTTCTGACCTTCTAGAAGTGCACAAG
AAACCCCTTCAGGAGGTAGAGATCGCAGCTGTGACCCACGGGGCGCTTCAGGGCCTGGCA
TATCTGCACTCCCACAACATGATCCATAGGGATGTGAAGGCTGGAAACATCCTGCTGTCA
GAGCCAGGGTTAGTGAAGCTAGGGGACTTTGGTTCTGCGTCCATCATGGCACCTGCCAAC
TCCTTCGTGGGCACCCCATACTGGATGGCACCCGAGGTGATCCTGGCCATGGATGAGGGG
CAGTACGATGGCAAAGTGGACGTCTGGTCCTTGGGGATAACCTGCATCGAGCTGGCTGAA
CGGAAACCACCGCTCTTTAACATGAATGCGATGAGTGCCTTATACCACATTGCACAGAAC
GAATCCCCCGTGCTCCAGTCAGGACACTGGTCTGAGTACTTCCGGAATTTTGTCGACTCC
TGTCTTCAGAAAATCCCTCAAGACAGACCAACCTCAGAGGTTCTCCTGAAGCACCGCTTT
GTGCTCCGGGAGCGGCCACCCACAGTCATCATGGACCTGATCCAGAGGACCAAGGATGCC
GTGCGGGAGCTGGACAACCTGCAGTACCGCAAGATGAAGAAGATCCTGTTCCAAGAGGCA
CCCAACGGCCCTGGTGCCGAGGCCCCAGAGGAGGAAGAGGAGGCCGAGCCCTACATGCAC
CGGGCCGGGACTCTGACCAGCCTCGAGAGTAGCCACTCAGTGCCCAGCATGTCCATCAGC
GCCTCCAGCCAGAGCAGCTCCGTCAACAGCCTAGCAGATGCCTCAGACAACGAGGAAGAG
GAGGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAAGGCCCTGAAGCCCGGGAGATGGCC
ATGATGCAGGAGGGGGAGCACACAGTCACCTCTCACAGCTCCATTATCCACCGGCTGCCG
GGCTCTGACAACCTATATGATGACCCCTACCAGCCAGAGATAACCCCCAGCCCTCTCCAG
CCGCCTGCAGCCCCAGCTCCCACTTCCACCACCTCTTCCGCCCGCCGCCGGGCCTACTGC
CGTAACCGAGACCACTTTGCCACCATCCGAACCGCCTCCCTGGTCAGCCGTCAGATCCAG
GAGCATGAGCAGGACTCTGCGCTGCGGGAGCAGCTGAGCGGCTATAAGCGGATGCGACGA
CAGCACCAGAAGCAGCTGCTGGCCCTGGAGTCACGGCTGAGGGGTGAACGGGAGGAGCAC
AGTGCACGGCTGCAGCGGGAGCTTGAGGCGCAGCGGGCTGGCTTTGGGGCAGAGGCAGAA
AAGCTGGCCCGGCGGCACCAGGCCATAGGTGAGAAGGAGGCACGAGCTGCCCAGGCCGAG
GAGCGGAAGTTCCAGCAGCACATCCTTGGGCAGCAGAAGAAGGAGCTGGCTGCCCTGCTG
GAGGCACAGAAGCGGACCTACAAACTTCGCAAGGAACAGCTGAAGGAGGAGCTCCAGGAG
AACCCCAGCACTCCCAAGCGGGAGAAGGCCGAGTGGCTGCTGCGGCAGAAGGAGCAGCTC
CAGCAGTGCCAGGCGGAGGAGGAAGCAGGGCTGCTGCGGCGGCAGCGCCAGTACTTTGAG
CTGCAGTGTCGCCAGTACAAGCGCAAGATGTTGCTGGCTCGGCACAGCCTGGACCAGGAC
CTGCTGCGGGAGGACCTGAACAAGAAGCAGACCCAGAAGGACTTGGAGTGTGCACTGCTG
CTTCGGCAGCACGAGGCCACGCGGGAGCTGGAGCTGCGGCAGCTCCAGGCCGTGCAGCGC
ACGCGGGCTGAGCTCACCCGCCTGCAGCACCAGACGGAGCTGGGCAACCAGCTGGAGTAC
AACAAGCGGCGTGAGCAAGAGTTGCGGCAGAAGCATGCGGCCCAGGTTCGCCAGCAGCCC
AAGAGCCTCAAAGTACGTGCAGGCCAGCGCCCCCCGGGCCTTCCACTCCCCATTCCTGGG
GCTCTGGGCCCACCCAACACAGGCACCCCTATAGAACAGCAGCCCTGCTCACCTGGCCAG
GAGGCAGTCCTGGACCAAAGAATGCTTGGCGAGGAGGAGGAAGCAGTTGGAGAGAGAAGG
ATTCTGGGAAAGGAAGGGGCCACTTTGGAGCCCAAGCAGCAGAGGATTCTGGGGGAAGAA
TCAGGAGCCCCTAGTCCCAGTCCACAAAAACATGGGAGCCTGGTTGATGAGGAAGTTTGG
GGTCTGCCTGAGGAGATAGAGGAGCTTAGGGTGCCCTCCCTTGTACCCCAGGAGAGGAGC
ATTGTTGGCCAGGAGGAGGCTGGGACATGGAGCTTGTGGGGGAAGGAGGATGAGAGTCTT
CTGGATGAGGAGTTTGAGCTTGGCTGGGTCCAGGGCCCAGCACTGACTCCCGTCCCTGAG
GAGGAGGAAGAAGAGGAAGAGGGGGCTCCGATTGGGACCCCTAGGGATCCTGGAGATGGT
TGTCCTTCCCCCGACATCCCTCCTGAACCCCCTCCAACACACCTGAGGCCCTGCCCTGCC
AGCCAGCTCCCTGGACTCCTGTCCCATGGCCTCCTGGCCGGCCTCTCCTTTGCAGTGGGG
TCCTCCTCTGGCCTCCTGCCCCTCCTGCTGCTGCTGCTGCTTCCATTGCTGGCAGCCCAG
GGTGGGGGTGGCCTGCAGGCAGCGCTGCTGGCCCTTGAGGTGGGGCTGGTGGGTCTGGGG
GCCTCCTACCTGCTCCTTTGTACAGCCCTGCACCTGCCCTCCAGTCTTTTCCTACTCCTG
GCCCAGGGTACCGCACTGGGGGCCGTCCTGGGCCTGAGCTGGCGCCGAGGCCTCATGGGT
GTTCCCCTGGGCCTTGGAGCTGCCTGGCTCTTAGCTTGGCCAGGCCTAGCTCTACCTCTG
GTGGCTATGGCAGCGGGGGGCAGATGGGTGCGGCAGCAGGGCCCCCGGGTGCGCCGGGGC
ATATCTCGACTCTGGTTGCGGGTTCTGCTGCGCCTGTCACCCATGGCCTTCCGGGCCCTG
CAGGGCTGTGGGGCTGTGGGGGACCGGGGTCTGTTTGCACTGTACCCCAAAACCAACAAG
GATGGCTTCCGCAGCCGCCTGCCCGTCCCTGGGCCCCGGCGGCGTAATCCCCGCACCACC
CAACACCCATTAGCTCTGTTGGCAAGGGTCTGGGTCCTGTGCAAGGGCTGGAACTGGCGT
CTGGCACGGGCCAGCCAGGGTTTAGCATCCCACTTGCCCCCGTGGGCCATCCACACACTG
GCCAGCTGGGGCCTGCTTCGGGGTGAACGGCCCACCCGAATCCCCCGGCTACTACCACGC
AGCCAGCGCCAGCTAGGGCCCCCTGCCTCCCGCCAGCCACTGCCAGGGACTCTAGCCGGG
CGGAGGTCACGCACCCGCCAGTCCCGGGCCCTGCCCCCCTGGAGGTAG

Protein Properties

Number of Residues

1235

Molecular Weight

138250.2

Theoretical pI

7.27

Pfam Domain Function

Pkinase (PF00069 )

Signals

["None"]

Transmembrane Regions

["965-985", "987-1007", "1012-1032", "1043-1063"]

Protein Sequence

>Serine/threonine-protein kinase TAO2
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ
EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW
GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE
EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG
SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL
AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG
ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT
QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR
SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR

External Links

GenBank ID Protein

45505130

UniProtKB/Swiss-Prot ID

Q9UL54

UniProtKB/Swiss-Prot Entry Name

TAOK2_HUMAN

PDB IDs