Cannabis Compound Database: Showing Protein Serine/threonine-protein kinase SRPK1 (CDBP04022)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP04022

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein kinase SRPK1

Description

Not Available

Synonyms

SFRS protein kinase 1
SR-protein-specific kinase 1
Serine/arginine-rich protein-specific kinase 1

Gene Name

SRPK1

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids

GO Classification

Function
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation

Cellular Location

Nucleus
Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:6

Locus

6p21.31

SNPs

SRPK1

Gene Sequence

>1968 bp
ATGGAGCGGAAAGTGCTTGCGCTCCAGGCCCGAAAGAAAAGGACCAAGGCCAAGAAGGAC
AAAGCCCAAAGGAAATCTGAAACTCAGCACCGAGGCTCTGCTCCCCACTCTGAGAGTGAT
CTACCAGAGCAGGAAGAGGAGATTCTGGGATCTGATGATGATGAGCAAGAAGATCCTAAT
GATTATTGTAAAGGAGGTTATCATCTTGTGAAAATTGGAGATCTATTCAATGGGAGATAC
CATGTGATCCGAAAGTTAGGCTGGGGACACTTTTCAACAGTATGGTTATCATGGGATATT
CAGGGGAAGAAATTTGTGGCAATGAAAGTAGTTAAAAGTGCTGAACATTACACTGAAACA
GCACTAGATGAAATCCGGTTGCTGAAGTCAGTTCGCAATTCAGACCCTAATGATCCAAAT
AGAGAAATGGTTGTTCAACTACTAGATGACTTTAAAATATCAGGAGTTAATGGAACACAT
ATCTGCATGGTATTTGAAGTTTTGGGGCATCATCTGCTCAAGTGGATCATCAAATCCAAT
TATCAGGGGCTTCCACTGCCTTGTGTCAAAAAAATTATTCAGCAAGTGTTACAGGGTCTT
GATTATTTACATACCAAGTGCCGTATCATCCACACTGACATTAAACCAGAGAACATCTTA
TTGTCAGTGAATGAGCAGTACATTCGGAGGCTGGCTGCAGAAGCAACAGAATGGCAGCGA
TCTGGAGCTCCTCCGCCTTCCGGATCTGCAGTCAGTACTGCTCCCCAGCCTAAACCAGCT
GACAAAATGTCAAAGAATAAGAAGAAGAAATTGAAGAAGAAGCAGAAGCGCCAGGCAGAA
TTACTAGAGAAGCGAATGCAGGAAATTGAGGAAATGGAGAAAGAGTCGGGCCCTGGGCAA
AAAAGACCAAACAAGCAAGAAGAATCAGAGAGTCCTGTTGAAAGACCCTTGAAAGAGAAC
CCACCTAATAAAATGACCCAAGAAAAACTTGAAGAGTCAAGTACCATTGGCCAGGATCAA
ACGCTTATGGAACGTGATACAGAGGGTGGTGCAGCAGAAATTAATTGCAATGGAGTGATT
GAAGTCATTAATTATACTCAGAACAGTAATAATGAAACATTGAGACATAAAGAGGATCTA
CATAATGCTAATGACTGTGATGTCCAAAATTTGAATCAGGAATCTAGTTTCCTAAGCTCC
CAAAATGGAGACAGCAGCACATCTCAAGAAACAGACTCTTGTACACCTATAACATCTGAG
GTGTCAGACACCATGGTGTGCCAGTCTTCCTCAACTGTAGGTCAGTCATTCAGTGAACAA
CACATTAGCCAACTTCAAGAAAGCATTCGGGCAGAGATACCCTGTGAAGATGAACAAGAG
CAAGAACATAACGGACCACTGGACAACAAAGGAAAATCCACGGCTGGAAATTTTCTTGTT
AATCCCCTTGAGCCAAAAAATGCAGAAAAGCTCAAGGTGAAGATTGCTGACCTTGGAAAT
GCTTGTTGGGTGCACAAACATTTCACTGAAGATATTCAAACAAGGCAATATCGTTCCTTG
GAAGTTCTAATCGGATCTGGCTATAATACCCCTGCTGACATTTGGAGCACGGCATGCATG
GCCTTTGAACTGGCCACAGGTGACTATTTGTTTGAACCTCATTCAGGGGAAGAGTACACT
CGAGATGAAGATCACATTGCATTGATCATAGAACTTCTGGGGAAGGTGCCTCGCAAGCTC
ATTGTGGCAGGAAAATATTCCAAGGAATTTTTCACCAAAAAAGGTGACCTGAAACATATC
ACGAAGCTGAAACCTTGGGGCCTTTTTGAGGTTCTAGTGGAGAAGTATGAGTGGTCGCAG
GAAGAGGCAGCTGGCTTCACAGATTTCTTACTGCCCATGTTGGAGCTGATCCCTGAGAAG
AGAGCCACTGCCGCCGAGTGTCTCCGGCACCCTTGGCTTAACTCCTAA

Protein Properties

Number of Residues

655

Molecular Weight

74324.3

Theoretical pI

6.09

Pfam Domain Function

Pkinase (PF00069 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Serine/threonine-protein kinase SRPK1
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS

External Links

GenBank ID Protein

47419936

UniProtKB/Swiss-Prot ID

Q96SB4

UniProtKB/Swiss-Prot Entry Name

SRPK1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_003137.4

GeneCard ID