| Identification |
|---|
| HMDB Protein ID
| CDBP04008 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1L |
| Description
| Not Available |
| Synonyms
|
- PP2C-epsilon
- Protein phosphatase 1-like
- Protein phosphatase 2C isoform epsilon
|
| Gene Name
| PPM1L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.
|
| GO Classification
|
| Biological Process |
| phospholipid metabolic process |
| sphingolipid biosynthetic process |
| MAPK cascade |
| protein dephosphorylation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| small molecule metabolic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| macromolecular complex |
| protein complex |
| protein serine/threonine phosphatase complex |
| Function |
| protein serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q26.1 |
| SNPs
| PPM1L |
| Gene Sequence
|
>1083 bp
ATGATAGAGGATACAATGACTTTGCTGTCTCTGCTGGGTCGCATCATGCGCTACTTCTTG
CTGAGACCCGAGACGCTTTTCCTGCTGTGCATCAGCTTGGCTCTATGGAGTTACTTCTTC
CACACCGACGAGGTGAAGACCATCGTGAAGTCCAGCCGGGACGCCGTGAAGATGGTGAAG
GGCAAGGTAGCCGAGATCATGCAGAACGATCGACTCGGGGGGCTTGATGTGCTCGAGGCC
GAGTTTTCCAAGACCTGGGAGTTCAAGAACCACAACGTGGCGGTGTACTCCATCCAGGGC
CGGAGAGACCACATGGAGGACCGCTTCGAAGTTCTCACGGATCTGGCCAACAAGACGCAC
CCGTCCATCTTCGGGATCTTCGACGGGCACGGGGGAGAGACTGCAGCTGAATATGTAAAA
TCTCGACTCCCAGAGGCCCTTAAACAGCATCTTCAGGACTACGAGAAAGACAAAGAAAAT
AGTGTATTATCTTACCAGACCATCCTTGAACAGCAGATTTTGTCAATTGACCGAGAAATG
CTAGAAAAATTGACTGTATCCTATGATGAAGCAGGCACAACGTGTTTGATTGCTCTGCTA
TCAGATAAAGACCTCACTGTGGCCAACGTGGGTGACTCGCGCGGGGTCCTGTGTGACAAA
GATGGGAACGCTATTCCTTTGTCTCATGATCACAAGCCTTACCAGTTGAAGGAAAGAAAG
AGGATAAAGAGAGCAGGTGGTTTCATCAGTTTCAATGGCTCCTGGAGGGTCCAGGGAATC
CTGGCCATGTCTCGGTCCCTGGGGGATTATCCGCTGAAAAATCTCAACGTGGTCATCCCA
GACCCAGACATCCTGACCTTTGACCTGGACAAGCTTCAGCCTGAGTTCATGATCTTGGCA
TCAGATGGTCTCTGGGATGCTTTCAGCAATGAAGAAGCAGTTCGATTCATCAAGGAGCGC
TTGGATGAACCTCACTTTGGGGCCAAGAGCATAGTTTTACAGTCATTTTACAGAGGCTGC
CCTGACAATATAACAGTCATGGTGGTGAAGTTCAGAAATAGCAGCAAAACAGAAGAGCAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 360 |
| Molecular Weight
| 41052.605 |
| Theoretical pI
| 5.876 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase 1L
MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVK
GKVAEIMQNDRLGGLDVLEAEFSKTWEFKNHNVAVYSIQGRRDHMEDRFEVLTDLANKTH
PSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLSYQTILEQQILSIDREM
LEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERK
RIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILA
SDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ
|
| External Links |
|---|
| GenBank ID Protein
| 63003905 |
| UniProtKB/Swiss-Prot ID
| Q5SGD2 |
| UniProtKB/Swiss-Prot Entry Name
| PPM1L_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_139245.2 |
| GeneCard ID
| PPM1L |
| GenAtlas ID
| PPM1L |
| HGNC ID
| HGNC:16381 |
| References |
|---|
| General References
| Not Available |