| Identification |
|---|
| HMDB Protein ID
| CDBP04007 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1K, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- PP2C domain-containing protein phosphatase 1K
- PP2C-kappa
- PP2C-like mitochondrial protein
- PP2C-type mitochondrial phosphoprotein phosphatase
- PTMP
- Protein phosphatase 2C isoform kappa
|
| Gene Name
| PPM1K |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
|
| GO Classification
|
| Biological Process |
| protein dephosphorylation |
| Cellular Component |
| mitochondrial matrix |
| mitochondrion |
| Component |
| macromolecular complex |
| protein complex |
| protein serine/threonine phosphatase complex |
| Function |
| protein serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q22.1 |
| SNPs
| PPM1K |
| Gene Sequence
|
>1119 bp
ATGTCAACAGCTGCCTTAATTACTTTGGTCAGAAGTGGTGGGAACCAGGTGAGAAGGAGA
GTGCTGCTAAGCTCCCGCCTGCTGCAGGACGACAGGCGGGTGACACCCACGTGCCACAGC
TCCACTTCAGAGCCTAGGTGTTCTCGGTTTGACCCAGATGGTAGTGGGAGTCCAGCTACC
TGGGACAATTTTGGGATCTGGGATAACCGCATTGATGAGCCAATTCTGCTGCCACCCAGC
ATTAAGTATGGCAAGCCAATTCCCAAAATCAGCTTGGAAAATGTGGGGTGCGCCTCACAG
ATTGGCAAACGGAAAGAGAATGAAGATCGGTTTGACTTCGCTCAGCTGACAGATGAGGTC
CTGTACTTTGCAGTGTATGATGGACACGGTGGACCTGCAGCAGCTGATTTCTGTCATACC
CACATGGAGAAATGTATTATGGATTTGCTTCCTAAGGAGAAGAACTTGGAAACTCTGTTG
ACCTTGGCTTTTCTAGAAATAGATAAAGCCTTTTCGAGTCATGCCCGCCTGTCTGCTGAT
GCAACTCTTCTGACCTCTGGGACTACTGCAACAGTAGCCCTATTGCGAGATGGTATTGAA
CTGGTTGTAGCCAGTGTTGGGGACAGCCGGGCTATTTTGTGTAGAAAAGGAAAACCCATG
AAGCTGACCATTGACCATACTCCAGAAAGAAAAGATGAAAAAGAAAGGATCAAGAAATGT
GGTGGTTTTGTAGCTTGGAATAGTTTGGGGCAGCCTCACGTAAATGGCAGGCTTGCAATG
ACAAGAAGTATTGGAGATTTGGACCTTAAGACCAGTGGTGTCATAGCAGAACCTGAAACT
AAGAGGATTAAGTTACATCATGCTGATGACAGCTTCCTGGTCCTCACCACAGATGGAATT
AACTTCATGGTGAATAGTCAAGAGATTTGTGACTTTGTCAATCAGTGCCATGATCCCAAC
GAAGCAGCCCATGCGGTGACTGAACAGGCAATACAGTACGGTACTGAGGATAACAGTACT
GCAGTAGTAGTGCCTTTTGGTGCCTGGGGAAAATATAAGAACTCTGAAATCAACTTCTCA
TTCAGCAGAAGCTTTGCCTCCAGTGGACGATGGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 372 |
| Molecular Weight
| 40996.965 |
| Theoretical pI
| 6.742 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase 1K, mitochondrial
MSTAALITLVRSGGNQVRRRVLLSSRLLQDDRRVTPTCHSSTSEPRCSRFDPDGSGSPAT
WDNFGIWDNRIDEPILLPPSIKYGKPIPKISLENVGCASQIGKRKENEDRFDFAQLTDEV
LYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARLSAD
ATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKC
GGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGI
NFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWGKYKNSEINFS
FSRSFASSGRWA
|
| External Links |
|---|
| GenBank ID Protein
| 167466276 |
| UniProtKB/Swiss-Prot ID
| Q8N3J5 |
| UniProtKB/Swiss-Prot Entry Name
| PPM1K_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_152542.3 |
| GeneCard ID
| PPM1K |
| GenAtlas ID
| PPM1K |
| HGNC ID
| HGNC:25415 |
| References |
|---|
| General References
| Not Available |