Cannabis Compound Database: Showing Protein Protein phosphatase 1F (CDBP04005)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP04005

Secondary Accession Numbers

Not Available

Name

Protein phosphatase 1F

Description

Not Available

Synonyms

Ca(2+)/calmodulin-dependent protein kinase phosphatase
CaM-kinase phosphatase
CaMKPase
Partner of PIX 2
Protein fem-2 homolog
hFem-2

Gene Name

PPM1F

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

GO Classification

Biological Process
negative regulation of transcription, DNA-dependent
positive regulation of gene expression
peptidyl-threonine dephosphorylation
positive regulation of stress fiber assembly
negative regulation of peptidyl-serine phosphorylation
negative regulation of protein kinase activity by regulation of protein phosphorylation
positive regulation of chemotaxis
positive regulation of focal adhesion assembly
positive regulation of growth
cellular response to drug
positive regulation of epithelial cell migration
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
cytosol
protein complex
Component
macromolecular complex
protein complex
protein serine/threonine phosphatase complex
Function
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein serine/threonine phosphatase activity
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
Molecular Function
metal ion binding
calmodulin-dependent protein phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Cytoplasmic

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

22q11.22

SNPs

PPM1F

Gene Sequence

>1365 bp
ATGTCCTCTGGAGCCCCACAGAAGAGCAGCCCAATGGCCAGTGGAGCTGAGGAGACCCCA
GGCTTCCTGGACACGCTCCTGCAAGACTTCCCAGCCCTGCTGAACCCAGAGGACCCTCTG
CCATGGAAGGCCCCAGGGACGGTGCTCAGCCAGGAGGAGGTGGAGGGCGAGCTGGCTGAG
CTGGCCATGGGCTTTCTGGGCAGCAGGAAGGCCCCGCCACCACTTGCTGCTGCTCTGGCC
CACGAAGCAGTTTCACAGCTGCTACAGACAGACCTTTCCGAATTCAGGAAGTTGCCCAGG
GAGGAAGAAGAAGAGGAGGAGGACGATGACGAGGAGGAAAAGGCCCCTGTGACCTTGCTG
GATGCCCAAAGCCTGGCACAGAGTTTCTTTAACCGCCTTTGGGAAGTCGCCGGCCAGTGG
CAGAAGCAGGTGCCATTGGCTGCCCGGGCCTCACAGCGGCAGTGGCTGGTCTCCATCCAC
GCCATCCGGAACACTCGCCGCAAGATGGAGGACCGGCACGTGTCCCTCCCTTCCTTCAAC
CAGCTCTTCGGCTTGTCTGACCCTGTGAACCGCGCCTACTTTGCTGTGTTTGATGGTCAC
GGAGACGTGGATGCTGCGAGGTACGCCGCTGTCCACGTGCACACCAACGCTGCCCGCCAG
CCAGAGCTGCCCACAGACCCTGAGGGAGCCCTCAGAGAAGCCTTCCGGCGCACCGACCAG
ATGTTTCTCAGGAAAGCCAAGCGAGAGCGGCTGCAGAGCGGCACCACAGGTGTGTGTGCG
CTCATTGCAGGAGCGACCCTGCACGTCGCCTGGCTCGGGGATTCCCAGGTCATTTTGGTA
CAGCAGGGACAGGTGGTGAAGCTGATGGAGCCACACAGACCAGAACGGCAGGATGAGAAG
GCGCGCATTGAAGCATTGGGTGGCTTTGTGTCTCACATGGACTGCTGGAGAGTCAACGGG
ACCCTGGCCGTCTCCAGAGCCATCGGGGATGTCTTCCAGAAGCCCTACGTGTCTGGGGAG
GCCGATGCAGCTTCCCGGGCGCTGACGGGCTCCGAGGACTACCTGCTGCTTGCCTGTGAT
GGCTTCTTTGACGTCGTACCCCACCAGGAAGTTGTTGGCCTGGTCCAGAGCCACCTGACC
AGGCAGCAGGGCAGCGGGCTCCGTGTCGCCGAGGAGCTGGTGGCTGCGGCCCGGGAGCGG
GGCTCCCACGACAACATCACGGTCATGGTGGTCTTCCTCAGGGACCCCCAAGAGCTGCTG
GAGGGCGGGAACCAGGGAGAAGGGGACCCCCAGGCAGAAGGGAGGAGGCAGGACTTGCCC
TCCAGCCTTCCAGAACCTGAGACCCAGGCTCCACCAAGAAGCTAG

Protein Properties

Number of Residues

454

Molecular Weight

49830.435

Theoretical pI

5.094

Pfam Domain Function

PP2C (PF00481 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Protein phosphatase 1F
MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAE
LAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLL
DAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFN
QLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQ
MFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEK
ARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACD
GFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELL
EGGNQGEGDPQAEGRRQDLPSSLPEPETQAPPRS

External Links

GenBank ID Protein

16223994

UniProtKB/Swiss-Prot ID

P49593

UniProtKB/Swiss-Prot Entry Name

PPM1F_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF305840

GeneCard ID