| Identification |
|---|
| HMDB Protein ID
| CDBP04001 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase 1A |
| Description
| Not Available |
| Synonyms
|
- PP2C-alpha
- Protein phosphatase 2C isoform alpha
- Protein phosphatase IA
|
| Gene Name
| PPM1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.
|
| GO Classification
|
| Biological Process |
| cell cycle arrest |
| insulin receptor signaling pathway |
| Wnt receptor signaling pathway |
| positive regulation of transcription, DNA-dependent |
| negative regulation of transcription from RNA polymerase II promoter |
| positive regulation of I-kappaB kinase/NF-kappaB cascade |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| transforming growth factor beta receptor signaling pathway |
| peptidyl-threonine dephosphorylation |
| transcription initiation from RNA polymerase II promoter |
| negative regulation of SMAD protein complex assembly |
| positive regulation of Wnt receptor signaling pathway |
| Cellular Component |
| voltage-gated calcium channel complex |
| cytosol |
| nucleoplasm |
| neuron projection |
| Component |
| macromolecular complex |
| protein complex |
| protein serine/threonine phosphatase complex |
| Function |
| magnesium ion binding |
| protein serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| manganese ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| transition metal ion binding |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| manganese ion binding |
| magnesium ion binding |
| signal transducer activity |
| calmodulin-dependent protein phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q23.1 |
| SNPs
| PPM1A |
| Gene Sequence
|
>1149 bp
ATGGGAGCATTTTTAGACAAGCCAAAGATGGAAAAGCATAATGCCCAGGGGCAGGGTAAT
GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGTGTTGAAATGGAGGATGCACAT
ACGGCTGTGATCGGTTTGCCAAGTGGACTTGAATCGTGGTCATTCTTTGCTGTGTATGAT
GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC
AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA
ATCAGAACAGGTTTTCTGGAGATTGATGAACACATGAGAGTTATGTCAGAGAAGAAACAT
GGTGCAGATAGAAGTGGGTCAACAGCTGTAGGTGTCTTAATTTCTCCCCAACATACTTAT
TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTCATTTCTTC
ACACAAGATCACAAACCAAGTAATCCGCTGGAGAAAGAACGAATTCAGAATGCAGGTGGC
TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTATCGAGGGCCCTTGGGGATTTT
GATTACAAATGCGTCCATGGAAAAGGTCCTACTGAGCAGCTTGTCTCACCAGAGCCTGAA
GTCCATGATATTGAAAGATCTGAAGAAGATGATCAGTTCATTATCCTTGCATGTGATGGT
ATCTGGGATGTTATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC
ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT
CGAGACAACATGAGTGTGATTTTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA
GCAGTGAAGAAGGAGGCAGAGTTGGACAAGTACCTGGAATGCAGAGTAGAAGAAATCATA
AAGAAGCAGGGGGAAGGCGTCCCCGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG
AACATCCCCAGCCTCCCACCAGGGGGTGAATTGGCAAGCAAGAGGAATGTTATTGAAGCC
GTTTACAATAGACTGAATCCTTACAAAAATGACGACACTGACTCTACATCAACAGATGAT
ATGTGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 382 |
| Molecular Weight
| 42447.455 |
| Theoretical pI
| 5.363 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase 1A
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA
VYNRLNPYKNDDTDSTSTDDMW
|
| External Links |
|---|
| GenBank ID Protein
| 197692195 |
| UniProtKB/Swiss-Prot ID
| P35813 |
| UniProtKB/Swiss-Prot Entry Name
| PPM1A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB451247 |
| GeneCard ID
| PPM1A |
| GenAtlas ID
| PPM1A |
| HGNC ID
| HGNC:9275 |
| References |
|---|
| General References
| Not Available |