| Identification |
|---|
| HMDB Protein ID
| CDBP04000 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nuclear inhibitor of protein phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- ARD-1
- Activator of RNA decay
- NIPP-1
- Protein phosphatase 1 regulatory inhibitor subunit 8
|
| Gene Name
| PPP1R8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Isoform Gamma:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p35 |
| SNPs
| PPP1R8 |
| Gene Sequence
|
>1056 bp
ATGGCGGCAGCCGCGAACTCCGGCTCTAGCCTCCCGCTGTTCGACTGCCCAACCTGGGCA
GGTAAGCCCCCTCCCGGTTTACATCTGGATGTAGTCAAAGGAGACAAACTAATTGAGAAA
CTGATTATTGATGAGAAGAAGTATTACTTATTTGGGAGAAACCCTGATTTGTGTGACTTT
ACCATTGACCACCAGTCTTGCTCTCGGGTCCATGCTGCACTTGTCTACCACAAGCATCTG
AAGAGAGTTTTCCTGATAGATCTCAACAGTACACACGGCACTTTCTTGGGTCACATTCGG
TTGGAACCTCACAAGCCTCAGCAAATTCCCATCGATTCCACGGTCTCATTTGGCGCATCC
ACAAGGGCATACACTCTGCGCGAGAAGCCTCAGACATTGCCATCGGCTGTGAAAGGAGAT
GAGAAGATGGGTGGAGAGGATGATGAACTCAAGGGCTTACTGGGGCTTCCAGAGGAGGAA
ACTGAGCTTGATAACCTGACAGAGTTCAACACTGCCCACAACAAGCGGATTTCTACCCTT
ACCATTGAGGAGGGAAATCTGGACATTCAAAGACCAAAGAGGAAGAGGAAGAACTCACGG
GTGACATTCAGTGAGGATGATGAGATCATCAACCCAGAGGATGTGGATCCCTCAGTTGGT
CGATTCAGGAACATGGTGCAAACTGCAGTGGTCCCAGTCAAGAAGAAGCGTGTGGAGGGC
CCTGGCTCCCTGGGCCTGGAGGAATCAGGGAGCAGGCGCATGCAGAACTTTGCCTTCAGC
GGAGGACTCTACGGGGGCCTGCCCCCCACACACAGTGAAGCAGGCTCCCAGCCACATGGC
ATCCATGGGACAGCACTCATCGGTGGCTTGCCCATGCCATACCCAAACCTTGCCCCTGAT
GTGGACTTGACTCCTGTTGTGCCGTCAGCAGTGAACATGAACCCTGCACCAAACCCTGCA
GTCTATAACCCTGAAGCTGTAAATGAACCCAAGAAGAAGAAATATGCAAAAGAGGCTTGG
CCAGGCAAGAAGCCCACACCTTCCTTGCTGATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 38478.5 |
| Theoretical pI
| 7.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nuclear inhibitor of protein phosphatase 1
MAAAANSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDF
TIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGAS
TRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTL
TIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRVEG
PGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSEAGSQPHGIHGTALIGGLPMPYPNLAPD
VDLTPVVPSAVNMNPAPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
|
| External Links |
|---|
| GenBank ID Protein
| 4883485 |
| UniProtKB/Swiss-Prot ID
| Q12972 |
| UniProtKB/Swiss-Prot Entry Name
| PP1R8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF061958 |
| GeneCard ID
| PPP1R8 |
| GenAtlas ID
| PPP1R8 |
| HGNC ID
| HGNC:9296 |
| References |
|---|
| General References
| Not Available |