| Identification |
|---|
| HMDB Protein ID
| CDBP03999 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pyridoxal phosphate phosphatase PHOSPHO2 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| PHOSPHO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.
|
| GO Classification
|
| Biological Process |
| dephosphorylation |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| metal ion binding |
| pyridoxal phosphatase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q31.1 |
| SNPs
| PHOSPHO2 |
| Gene Sequence
|
>726 bp
ATGAAAATTTTGCTAGTTTTTGACTTTGACAATACAATCATAGATGACAATAGTGACACT
TGGATTGTACAATGTGCTCCCAACAAAAAGCTTCCTATTGAACTACGTGATTCTTATCGA
AAAGGATTTTGGACAGAATTTATGGGCAGAGTCTTTAAGTATTTGGGAGATAAGGGTGTA
AGAGAACATGAAATGAAAAGAGCAGTGACATCATTGCCTTTCACTCCAGGGATGGTGGAA
CTCTTCAACTTTATAAGAAAGAATAAGGATAAATTTGACTGCATTATTATTTCAGATTCA
AATTCGGTCTTCATAGATTGGGTTTTAGAAGCTGCCAGTTTTCATGACATATTTGATAAA
GTGTTTACAAATCCAGCAGCTTTTAATAGCAATGGTCATCTCACTGTTGAAAATTATCAT
ACTCATTCTTGCAATAGATGCCCAAAGAATCTTTGCAAAAAGGTAGTTTTGATAGAATTT
GTAGATAAACAGTTACAACAGGGAGTGAATTATACACAAATTGTTTATATTGGTGATGGT
GGAAATGATGTCTGTCCAGTCACCTTTTTAAAGAATGATGATGTTGCCATGCCACGGAAA
GGATATACCTTACAGAAAACTCTTTCCAGAATGTCTCAAAATCTTGAGCCTATGGAATAT
TCTGTTGTAGTTTGGTCCTCAGGTGTTGATATAATTTCTCATTTACAATTTCTAATAAAG
GATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 241 |
| Molecular Weight
| 27768.72 |
| Theoretical pI
| 6.781 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pyridoxal phosphate phosphatase PHOSPHO2
MKILLVFDFDNTIIDDNSDTWIVQCAPNKKLPIELRDSYRKGFWTEFMGRVFKYLGDKGV
REHEMKRAVTSLPFTPGMVELFNFIRKNKDKFDCIIISDSNSVFIDWVLEAASFHDIFDK
VFTNPAAFNSNGHLTVENYHTHSCNRCPKNLCKKVVLIEFVDKQLQQGVNYTQIVYIGDG
GNDVCPVTFLKNDDVAMPRKGYTLQKTLSRMSQNLEPMEYSVVVWSSGVDIISHLQFLIK
D
|
| External Links |
|---|
| GenBank ID Protein
| 56606064 |
| UniProtKB/Swiss-Prot ID
| Q8TCD6 |
| UniProtKB/Swiss-Prot Entry Name
| PHOP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001008489.2 |
| GeneCard ID
| PHOSPHO2 |
| GenAtlas ID
| PHOSPHO2 |
| HGNC ID
| HGNC:28316 |
| References |
|---|
| General References
| Not Available |