| Identification |
|---|
| HMDB Protein ID
| CDBP03989 |
| Secondary Accession Numbers
| Not Available |
| Name
| 8-oxo-dGDP phosphatase NUDT18 |
| Description
| Not Available |
| Synonyms
|
- Nudix motif 18
- 2-hydroxy-dADP phosphatase
- 7,8-dihydro-8-oxoguanine phosphatase
- MutT homolog 3
- Nucleoside diphosphate-linked moiety X motif 18
|
| Gene Name
| NUDT18 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
|
| GO Classification
|
| Biological Process |
| dADP catabolic process |
| dGDP catabolic process |
| GDP catabolic process |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| magnesium ion binding |
| 8-hydroxy-dADP phosphatase activity |
| 8-oxo-dGDP phosphatase activity |
| 8-oxo-GDP phosphatase activity |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p21.3 |
| SNPs
| NUDT18 |
| Gene Sequence
|
>972 bp
ATGGCCTCGGAGGGCCTGGCGGGGGCGCTGGCTTCCGTGCTGGCTGGCCAGGGGTCCAGC
GTGCACAGCTGCGACTCGGCGCCGGCCGGGGAGCCGCCGGCGCCCGTGCGGCTGCGGAAG
AACGTGTGCTACGTGGTGCTGGCCGTGTTCCTCAGCGAGCAGGATGAGGTGCTACTGATC
CAGGAGGCCAAGAGGGAGTGCCGGGGGTCGTGGTACCTGCCTGCGGGGAGAATGGAGCCA
GGGGAGACCATCGTGGAGGCGCTGCAGCGGGAGGTGAAGGAGGAGGCGGGGCTGCACTGT
GAGCCCGAGACACTGCTGTCCGTGGAGGAGCGGGGCCCCTCCTGGGTCCGCTTCGTGTTC
CTCGCTCGCCCCACAGGTGGAATTCTCAAGACTTCCAAGGAGGCCGATGCGGAGTCCCTG
CAGGCTGCCTGGTACCCACGGACCTCCCTGCCCACTCCGCTGCGAGCCCATGACATCCTG
CACCTGGTTGAACTAGCCGCCCAGTATCGCCAGCAAGCCAGGCACCCTCTCATTCTGCCC
CAAGAGCTACCCTGTGATCTGGTCTGCCAGCGGCTCGTGGCTACCTTTACCAGCGCCCAG
ACAGTGTGGGTGTTAGTGGGCACAGTGGGGATGCCTCACTTGCCTGTCACTGCCTGTGGC
CTCGACCCTATGGAGCAGAGGGGTGGCATGAAGATGGCCGTCCTGCGGCTGCTGCAGGAG
TGTCTGACCCTGCACCACTTGGTGGTGGAGATCAAGGGGTTGCTTGGACTGCAGCACCTG
GGCCGAGATCACAGTGATGGCATCTGTTTGAATGTGCTGGTGACCGTGGCTTTTCGGAGC
CCAGGGATCCAGGATGAACCCCCAAAAGTTCGGGGTGAGAACTTCTCTTGGTGGAAGGTG
ATGGAGGAAGACCTGCAAAGCCAGCTCCTCCAGCGGCTTCAGGGATCCTCTGTTGTCCCA
GTGAACAGATAG
|
| Protein Properties |
|---|
| Number of Residues
| 323 |
| Molecular Weight
| 35500.76 |
| Theoretical pI
| 6.227 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nucleoside diphosphate-linked moiety X motif 18
MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLI
QEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVF
LARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILP
QELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPVEQRGGMKMAVLRLLQE
CLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKV
MEEDLQSQLLQRLQGSSVVPVNR
|
| External Links |
|---|
| GenBank ID Protein
| 118026927 |
| UniProtKB/Swiss-Prot ID
| Q6ZVK8 |
| UniProtKB/Swiss-Prot Entry Name
| NUD18_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_024815.3 |
| GeneCard ID
| NUDT18 |
| GenAtlas ID
| NUDT18 |
| HGNC ID
| HGNC:26194 |
| References |
|---|
| General References
| Not Available |