| Identification |
|---|
| HMDB Protein ID
| CDBP03987 |
| Secondary Accession Numbers
| Not Available |
| Name
| Probable 8-oxo-dGTP diphosphatase NUDT15 |
| Description
| Not Available |
| Synonyms
|
- 8-oxo-dGTPase NUDT15
- MTH2
- MutT homolog 2
- Nucleoside diphosphate-linked moiety X motif 15
- Nudix motif 15
- 7,8-dihydro-8-oxoguanine-triphosphatase NUDT15
|
| Gene Name
| NUDT15 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
|
| GO Classification
|
| Biological Process |
| GTP catabolic process |
| dGTP catabolic process |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| 13q14.2 |
| SNPs
| NUDT15 |
| Gene Sequence
|
>495 bp
ATGACGGCCAGCGCACAGCCGCGCGGGCGGCGGCCAGGAGTCGGAGTCGGAGTCGTGGTG
ACCAGCTGCAAGCATCCGCGTTGCGTCCTCCTGGGGAAGAGGAAAGGCTCGGTTGGAGCT
GGCAGTTTCCAACTCCCTGGAGGTCATCTGGAGTTCGGTGAAACCTGGGAAGAATGTGCT
CAAAGGGAAACCTGGGAAGAAGCAGCTCTTCACCTGAAAAATGTTCACTTTGCCTCAGTT
GTGAATTCTTTCATTGAGAAGGAGAATTACCATTATGTTACTATATTAATGAAAGGAGAA
GTGGATGTGACTCATGATTCAGAACCAAAGAATGTAGAGCCTGAAAAAAATGAAAGTTGG
GAGTGGGTTCCTTGGGAAGAACTACCTCCCCTGGACCAGCTTTTCTGGGGACTGCGTTGT
TTAAAAGAACAAGGCTATGATCCATTTAAAGAAGATCTGAACCATCTGGTGGGATACAAA
GGAAATCATCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 164 |
| Molecular Weight
| 18608.965 |
| Theoretical pI
| 6.133 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESW
EWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL
|
| External Links |
|---|
| GenBank ID Protein
| 7023325 |
| UniProtKB/Swiss-Prot ID
| Q9NV35 |
| UniProtKB/Swiss-Prot Entry Name
| NUD15_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK001818 |
| GeneCard ID
| NUDT15 |
| GenAtlas ID
| NUDT15 |
| HGNC ID
| HGNC:23063 |
| References |
|---|
| General References
| Not Available |