| Identification |
|---|
| HMDB Protein ID
| CDBP03984 |
| Secondary Accession Numbers
| Not Available |
| Name
| Endonuclease G, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Endo G
|
| Gene Name
| ENDOG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleic acid binding |
| Specific Function
| Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| nucleic acid binding |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34.1 |
| SNPs
| ENDOG |
| Gene Sequence
|
>894 bp
ATGCGGGCGCTGCGGGCCGGCCTGACCCTGGCGTCGGGCGCGGGGCTGGGTGCGGTCGTC
GAGGGCTGGCGGCGGCGGCGGGAGGACGCGCGGGCGGCGCCGGGACTGCTGGGCCGGCTG
CCCGTGCTGCCCGTGGCGGCGGCAGCCGAGTTGCCCCCTGTGCCCGGGGGACCCCGCGGC
CCGGGCGAGCTGGCCAAGTACGGGCTGCCGGGGCTGGCGCAGCTCAAGAGCCGCGAGTCG
TACGTGCTGTGCTACGACCCGCGCACCCGCGGCGCGCTCTGGGTGGTGGAGCAGCTGCGA
CCCGAGCGTCTCCGCGGCGACGGCGACCGGCGCGAGTGCGACTTCCGCGAGGACGACTCG
GTGCACGCGTACCACCGTGCCACCAACGCCGACTACCGCGGCAGTGGCTTCGACCGCGGT
CACCTGGCCGCCGCCGCCAACCACCGCTGGAGCCAGAAGGCCATGGACGACACGTTCTAC
CTGAGCAACGTCGCGCCCCAGGTGCCCCACCTCAACCAGAATGCCTGGAACAACCTGGAG
AAATATAGCCGCAGCTTGACCCGCAGCTACCAAAACGTCTATGTCTGCACAGGGCCACTC
TTCCTGCCCAGGACAGAGGCTGATGGGAAATCCTACGTAAAGTACCAGGTCATCGGCAAG
AACCACGTGGCAGTGCCCACACACTTCTTCAAGGTGCTGATCCTGGAGGCAGCAGGTGGG
CAAATTGAGCTCCGCACCTACGTGATGCCCAACGCACCTGTGGATGAGGCCATCCCACTG
GAGCGCTTCCTGGTGCCCATCGAGAGCATTGAGCGGGCTTCGGGGCTGCTCTTTGTGCCA
AACATCCTGGCGCGGGCAGGCAGCCTCAAGGCCATCACGGCGGGCAGTAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 297 |
| Molecular Weight
| 32646.0 |
| Theoretical pI
| 9.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Endonuclease G, mitochondrial
MRALRAGLTLALGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRG
PGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDS
VHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLE
KYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGG
QIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
|
| External Links |
|---|
| GenBank ID Protein
| 55960038 |
| UniProtKB/Swiss-Prot ID
| Q14249 |
| UniProtKB/Swiss-Prot Entry Name
| NUCG_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL441992 |
| GeneCard ID
| ENDOG |
| GenAtlas ID
| ENDOG |
| HGNC ID
| HGNC:3346 |
| References |
|---|
| General References
| Not Available |