| Identification |
|---|
| HMDB Protein ID
| CDBP03940 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA helicase B |
| Description
| Not Available |
| Synonyms
|
- hDHB
|
| Gene Name
| HELB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.
|
| GO Classification
|
| Biological Process |
| DNA replication, synthesis of RNA primer |
| Molecular Function |
| ATP binding |
| ATP-dependent 5'-3' DNA helicase activity |
| single-stranded DNA-dependent ATP-dependent DNA helicase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q |
| SNPs
| HELB |
| Gene Sequence
|
>3264 bp
ATGGCCAGGTCGAGTCCGTACCTGCGTCAACTTCAGGGACCTCTGCTCCCACCCAGGGAT
CTGGTGGAGGAGGACGACGACTACCTAAACGACGACGTGGAGGAGGATGAAGAGTCCGTG
TTCATCGACGCCGAGGAGCTCTGCAGTGGGGGCGTAAAGGCTGGCAGCCTCCCCGGGTGC
CTCCGCGTTTCTATTTGTGATGAAAACACACAAGAGACATGTAAAGTGTTTGGACGTTTT
CCGATAACAGGTGCTTGGTGGAGAGTGAAGGTACAAGTAAAGCCTGTGGTGGGATCAAGG
AGCTATCAATATCAAGTTCAAGGATTTCCGTCTTACTTTTTGCAGTCTGATATGTCACCA
CCAAATCAAAAACATATCTGTGCTCTCTTTCTTAAAGAGTGTGAGGTCTCCAGTGATGAT
GTTAATAAATTTTTAACATGGGTAAAGGAGGTATCAAACTACAAAAACCTAAACTTTGAA
AATCTTAGGGAAACACTAAGAACTTTCCACAAGGAAACTGGAAGGAAAGATCAAAAGCAG
CCTACACAGAATGGTCAGGAAGAGTTGTTCCCAGACAATGAGATGAGTCTTCCTCTGGAA
AACACAATTCCATTTAGAAATGTAATGACAGCTTTGCAGTTTCCGAAGATAATGGAATTC
CTTCCAGTTCTTCTGCCTCGACACTTTAAATGGATCATAGGGTCAGGTTCTAAAGAGATG
TTGAAAGAGATAGAAGAGATTTTAGGTACACATCCGTGGAAACTTGGATTTAGTAAAATA
ACCTACAGAGAGTGGAAACTCCTGCGATGTGAGGCAAGTTGGATAGCATTTTGTCAGTGT
GAGTCTCTTCTCCAGCTGATGACTGATTTGGAGAAGAATGCATTAATAATGTATTCCAGA
CTGAAGCAGATATGTAGAGAAGATGGGCACACATATGTTGAAGTGAATGACTTAACTTTG
ACATTGTCAAATCATATGTCATTTCATGCTGCTTCAGAGTCTCTGAAGTTTTTGAAGGAT
ATTGGTGTGGTGACATATGAGAAGTCCTGTGTCTTCCCTTATGACCTTTACCATGCTGAA
AGAGCCATCGCCTTTTCAATTTGTGACCTGATGAAGAAACCTCCTTGGCATTTATGTGTC
GATGTCGAAAAGGTGCTTGCCTCTATTCACACCACAAAACCTGAGAATTCAAGCGATGAT
GCATTGAATGAGAGCAAACCTGATGAAGTAAGATTAGAAAATCCTGTGGATGTTGTGGAC
ACACAGGACAATGGTGACCATATTTGGACTAATGGTGAAAATGAAATTAATGCAGAAATA
AGTGAAGTTCAGCTGGATCAGGATCAGGTTGAAGTTCCACTGGATCGGGATCAGGTGGCT
GCTTTGGAAATGATTTGCTCCAATCCTGTGACAGTCATAAGTGGGAAAGGTGGATGTGGG
AAGACCACAATCGTTAGCCGTCTTTTTAAGCATATAGAGCAGTTGGAAGAAAGAGAAGTA
AAAAAAGCCTGTGAAGATTTTGAACAAGACCAGAATGCTTCAGAAGAATGGATTACCTTT
ACTGAGCAAAGTCAACTAGAGGCGGACAAGGCTATAGAAGTTTTGCTCACAGCACCTACA
GGGAAAGCAGCTGGCTTACTAAGACAGAAAACTGGTCTTCATGCCTACACACTGTGTCAG
GTCAATTATAGCTTCTATTCATGGACTCAAACAATGATGACCACAAACAAACCATGGAAA
TTTTCTTCGGTTAGAGTTCTGGTTGTGGATGAAGGGAGTTTGGTATCTGTAGGGATCTTC
AAATCGGTCTTAAATTTATTGTGTGAGCACTCCAAACTTTCTAAGCTTATTATCCTTGGT
GACATTAGACAGTTACCCAGTATTGAACCTGGTAACTTGCTGAAAGATCTTTTTGAGACT
CTTAAGTCAAGAAATTGTGCTATTGAGCTAAAGACAAACCATAGAGCAGAATCTCAGCTC
ATTGTGGACAATGCTACAAGAATCTCAAGACGCCAATTTCCAAAATTTGATGCAGAACTA
AATATCTCTGATAATCCAACATTACCCATCTCAATTCAAGATAAGACATTTATTTTTGTC
AGGCTCCCAGAAGAGGATGCCAGTTCTCAGTCATCTAAAACTAATCATCACTCTTGTTTA
TATTCTGCAGTTAAAACTTTACTACAAGAAAATAACTTACAAAATGCAAAAACATCACAA
TTTATTGCATTTAGAAGGCAAGACTGTGATCTAATTAATGACTGCTGCTGCAAACACTAC
ACAGGCCACCTCACCAAAGACCATCAGAGTAGACTTGTTTTTGGAATTGGTGATAAAATT
TGTTGTACCAGGAATGCATACCTCTCAGACTTACTACCTGAAAATATCTCTGGAAGTCAG
CAAAATAATGATCTAGATGCCAGTAGTGAAGACTTTTCTGGTACGCTTCCTGATTTTGCT
AAAAATAAGCGTGACTTTGAAAGTAACGTTCGACTGTGCAATGGAGAGATATTTTTCATA
ACAAATGATGTAACTGATGTAACTTTTGGAAAGAGAAGATCTTTGACCATTAATAATATG
GCTGGCCTGGAAGTAACTGTGGATTTTAAGAAACTAATGAAATATTGTCGCATAAAACAT
GCATGGGCAAGAACTATTCACACTTTTCAGGGGTCCGAGGAGCAAACAGTTGTCTATGTG
GTGGGGAAGGCGGGCCGCCAGCACTGGCAGCATGTCTACACCGCCGTGACCAGGGGCCGC
TGCCGAGTGTATGTGATTGCAGAGGAGTCTCAGCTCCGGAATGCCATTATGAAAAACAGT
TTTCCTAGAAAAACTCGTTTGAAACATTTCTTGCAAAGTAAGCTCTCCTCTAGCGGCGCA
CCTCCAGCAGATTTTCCGTCCCCACGGAAGAGCTCTGGAGACAGTGGAGGACCCAGCACA
CCGTCAGCATCTCCACTCCCTGTAGTCACAGACCACGCCATGACAAATGATGTCACCTGG
AGCGAGGCCTCTTCGCCTGATGAGAGGACACTCACCTTTGCTGAAAGATGGCAATTATCT
TCACCTGATGGAGTAGATACAGATGATGATTTACCAAAATCGCGAGCATCCAAAAGAACC
TGTGGTGTGAATGATGATGAAAGTCCAAGCAAAATTTTTATGGTGGGAGAATCTCCACAA
GTGTCTTCCAGACTTCAGAATTTGAGACTGAATAATTTAATTCCCAGGCAACTTTTCAAG
CCCACCGATAATCAAGAAACTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1087 |
| Molecular Weight
| 123251.38 |
| Theoretical pI
| 5.867 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA helicase B
MARSSPYLRQLQGPLLPPRDLVEEDDDYLNDDVEEDEESVFIDAEELCSGGVKAGSLPGC
LRVSICDENTQETCKVFGRFPITGAWWRVKVQVKPVVGSRSYQYQVQGFPSYFLQSDMSP
PNQKHICALFLKECEVSSDDVNKFLTWVKEVSNYKNLNFENLRETLRTFHKETGRKDQKQ
PTQNGQEELFLDNEMSLPLENTIPFRNVMTALQFPKIMEFLPVLLPRHFKWIIGSGSKEM
LKEIEEILGTHPWKLGFSKITYREWKLLRCEASWIAFCQCESLLQLMTDLEKNALIMYSR
LKQICREDGHTYVEVNDLTLTLSNHMSFHAASESLKFLKDIGVVTYEKSCVFPYDLYHAE
RAIAFSICDLMKKPPWHLCVDVEKVLASIHTTKPENSSDDALNESKPDEVRLENPVDVVD
TQDNGDHIWTNGENEINAEISEVQLDQDQVEVPLDRDQVAALEMICSNPVTVISGKGGCG
KTTIVSRLFKHIEQLEEREVKKACEDFEQDQNASEEWITFTEQSQLEADKAIEVLLTAPT
GKAAGLLRQKTGLHAYTLCQVNYSFYSWTQTMMTTNKPWKFSSVRVLVVDEGSLVSVGIF
KSVLNLLCEHSKLSKLIILGDIRQLPSIEPGNLLKDLFETLKSRNCAIELKTNHRAESQL
IVDNATRISRRQFPKFDAELNISDNPTLPISIQDKTFIFVRLPEEDASSQSSKTNHHSCL
YSAVKTLLQENNLQNAKTSQFIAFRRQDCDLINDCCCKHYTGHLTKDHQSRLVFGIGDKI
CCTRNAYLSDLLPENISGSQQNNDLDASSEDFSGTLPDFAKNKRDFESNVRLCNGEIFFI
TNDVTDVTFGKRRSLTINNMAGLEVTVDFKKLMKYCRIKHAWARTIHTFQGSEEQTVVYV
VGKAGRQHWQHVYTAVTRGRCRVYVIAEESQLRNAIMKNSFPRKTRLKHFLQSKLSSSGA
PPADFPSPRKSSGDSGGPSTPSASPLPVVTDHAMTNDVTWSEASSPDERTLTFAERWQLS
SPDGVDTDDDLPKSRASKRTCGVNDDESPSKIFMVGESPQVSSRLQNLRLNNLIPRQLFK
PTDNQET
|
| External Links |
|---|
| GenBank ID Protein
| 21666081 |
| UniProtKB/Swiss-Prot ID
| Q8NG08 |
| UniProtKB/Swiss-Prot Entry Name
| HELB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF319995 |
| GeneCard ID
| HELB |
| GenAtlas ID
| HELB |
| HGNC ID
| HGNC:17196 |
| References |
|---|
| General References
| Not Available |