Cannabis Compound Database: Showing Protein Flap endonuclease GEN homolog 1 (CDBP03938)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03938

Secondary Accession Numbers

Not Available

Name

Flap endonuclease GEN homolog 1

Description

Not Available

Synonyms

Not Available

Gene Name

GEN1

Protein Type

Enzyme

Biological Properties

General Function

Involved in DNA binding

Specific Function

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'- upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded

GO Classification

Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
nucleic acid binding
dna binding
nuclease activity
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
dna metabolic process
dna repair

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2p24.2

SNPs

GEN1

Gene Sequence

>2727 bp
ATGGGAGTGAATGACTTGTGGCAAATTTTGGAGCCTGTTAAGCAACACATCCCCTTGCGT
AATCTTGGTGGGAAAACCATTGCAGTTGATCTGAGTCTCTGGGTGTGTGAGGCACAGACA
GTCAAAAAAATGATGGGCAGCGTCATGAAGCCCCACCTCAGGAACTTATTTTTTCGTATC
TCATATTTAACACAAATGGATGTAAAACTGGTATTTGTTATGGAAGGGGAACCACCAAAG
CTGAAAGCTGATGTCATAAGCAAGAGGAATCAGTCTCGGTATGGGTCTTCTGGAAAATCG
TGGTCTCAGAAAACAGGGAGATCACATTTTAAATCAGTCTTAAGAGAGTGCCTCCATATG
CTCGAATGCTTAGGAATCCCCTGGGTTCAGGCTGCTGGGGAAGCTGAAGCCATGTGTGCT
TATCTCAATGCTGGTGGTCATGTCGATGGCTGCCTCACCAATGATGGAGATACTTTCCTT
TATGGGGCCCAGACTGTTTACAGGAATTTCACTATGAATACAAAGGACCCACATGTTGAC
TGTTACACAATGTCATCTATCAAGAGTAAACTAGGTTTGGATAGAGATGCTCTGGTTGGA
TTAGCAATACTTCTTGGCTGTGATTATCTCCCAAAGGGAGTCCCTGGAGTTGGAAAAGAG
CAAGCATTAAAACTTATACAGATTTTGAAAGGGCAAAGTTTACTTCAGAGGTTTAATCGG
TGGAATGAAACATCTTGTAACTCTAGTCCACAACTGCTAGTCACTAAAAAACTGGCTCAT
TGTTCCGTATGTTCCCATCCAGGTTCACCTAAGGATCATGAACGTAATGGATGCAGATTA
TGTAAAAGTGATAAATATTGTGAGCCACATGACTATGAATACTGCTGTCCTTGTGAGTGG
CACCGTACAGAACATGATAGGCAACTCAGTGAAGTAGAGAACAATATTAAGAAGAAAGCT
TGCTGTTGTGAGGGATTCCCATTCCATGAGGTTATTCAAGAATTCCTTTTAAACAAGGAT
AAATTGGTGAAGGTTATCAGGTACCAAAGACCTGATTTGTTATTGTTTCAGAGATTTACT
CTTGAAAAAATGGAGTGGCCCAATCACTATGCATGTGAGAAATTGCTGGTACTTTTGACC
CATTATGACATGATAGAAAGAAAGCTTGGTAGCAGAAACTCTAATCAACTACAGCCAATT
CGAATTGTTAAGACTCGAATCAGAAATGGAGTTCATTGTTTTGAAATAGAATGGGAAAAG
CCTGAACATTATGCTATGGAAGATAAACAACATGGAGAATTTGCTTTATTAACAATTGAG
GAAGAATCATTGTTTGAAGCAGCATATCCTGAGATCGTTGCTGTTTACCAAAAACAAAAG
TTAGAAATTAAAGGGAAGAAACAAAAACGTATTAAGCCTAAAGAAAACAATTTGCCAGAA
CCAGATGAAGTAATGAGCTTTCAGTCACACATGACTTTAAAACCCACATGTGAAATCTTT
CATAAGCAGAATTCCAAGTTAAATTCGGGGATTTCCCCTGATCCTACATTACCACAGGAA
TCTATTTCTGCCTCATTGAATAGCTTGCTTTTACCTAAAAATACTCCATGTTTGAATGCA
CAAGAACAGTTCATGTCTTCTCTAAGACCTTTGGCTATACAGCAAATTAAAGCTGTCAGT
AAGTCTCTAATTTCAGAATCTAGTCAACCCAATACCTCATCTCATAATATATCCGTGATT
GCTGATCTACACTTGAGCACTATTGACTGGGAAGGTACTTCTTTTAGTAATTCTCCAGCT
ATTCAAAGGAATACTTTTTCTCATGATTTAAAATCAGAAGTTGAATCAGAGCTATCAGCC
ATCCCTGATGGCTTTGAAAATATCCCAGAACAACTGTCCTGTGAATCAGAAAGGTACACT
GCAAACATAAAGAAAGTGTTGGATGAGGATTCTGATGGGATTAGTCCTGAAGAGCATCTA
CTTTCTGGCATTACTGATTTATGTCTTCAGGATTTGCCTTTAAAGGAACGAATATTTACA
AAATTATCATATCCTCAGGATAATCTACAACCAGATGTCAACCTGAAAACTTTGTCCATA
CTTAGTGTAAAAGAATCTTGTATTGCTAACAGTGGTTCTGATTGTACATCACATCTTTCA
AAGGATCTTCCAGGAATTCCCTTGCAAAATGAATCCAGAGACTCTAAAATTCTAAAAGGA
GACCAGCTGCTTCAAGAAGACTATAAAGTCAATACTTCTGTCCCTTATTCTGTCAGTAAC
ACAGTGGTAAAGACCTGCAATGTTAGACCACCAAATACTGCTTTAGATCATAGTAGAAAA
GTTGATATGCAAACCACTCGGAAAATTTTAATGAAGAAGAGTGTTTGCCTTGACAGACAT
TCCTCTGATGAACAAAGTGCCCCAGTGTTTGGGAAAGCTAAGTACACAACTCAAAGAATG
AAGCACAGTTCTCAAAAGCATAATTCATCCCATTTCAAAGAAAGTGGCCATAACAAGTTG
AGTAGCCCTAAGATACATATTAAAGAAACTGAACAGTGTGTCAGATCTTATGAAACAGCT
GAAAATGAAGAAAGCTGTTTCCCAGATTCAACAAAAAGTTCTCTGAGTTCTCTACAATGT
CATAAGAAAGAAAACAACTCTGGTACTTGTTTGGATAGCCCTCTTCCTTTACGCCAGAGA
TTAAAACTAAGATTCCAAAGCACTTGA

Protein Properties

Number of Residues

908

Molecular Weight

102883.6

Theoretical pI

7.85

Pfam Domain Function

XPG_I (PF00867 )
XPG_N (PF00752 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Flap endonuclease GEN homolog 1
MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRI
SYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHM
LECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVD
CYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNR
WNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEW
HRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFT
LEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEK
PEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPE
PDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNA
QEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPA
IQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHL
LSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLS
KDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRK
VDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKL
SSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQR
LKLRFQST

External Links

GenBank ID Protein

194018535

UniProtKB/Swiss-Prot ID

Q17RS7

UniProtKB/Swiss-Prot Entry Name

GEN_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001130009.1

GeneCard ID