| Identification |
|---|
| HMDB Protein ID
| CDBP03926 |
| Secondary Accession Numbers
| Not Available |
| Name
| Enolase-phosphatase E1 |
| Description
| Not Available |
| Synonyms
|
- 2,3-diketo-5-methylthio-1-phosphopentane phosphatase
- MASA homolog
|
| Gene Name
| ENOPH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
|
| GO Classification
|
| Biological Process |
| L-methionine salvage from methylthioadenosine |
| polyamine metabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| acireductone synthase activity |
| phosphoglycolate phosphatase activity |
| Molecular Function |
| magnesium ion binding |
| acireductone synthase activity |
| phosphoglycolate phosphatase activity |
| Process |
| amino acid salvage |
| l-methionine salvage from methylthioadenosine |
| cellular amino acid and derivative metabolic process |
| cellular amino acid metabolic process |
| cellular amino acid biosynthetic process |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-methionine biosynthesis via salvage pathway | Not Available | Not Available | | Cysteine and methionine metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q21.22 |
| SNPs
| ENOPH1 |
| Gene Sequence
|
>786 bp
ATGGTCGTGCTTTCGGTCCCCGCCGAAGTCACCGTGATCCTGTTAGATATCGAAGGTACC
ACAACCCCGATTGCTTTCGTGAAGGACATTTTATTTCCTTACATCGAAGAAAATGTTAAA
GAGTATCTGCAGACACATTGGGAAGAAGAGGAGTGCCAGCAGGATGTCAGTCTTTTGAGG
AAACAGGCTGAAGAGGACGCCCACCTGGATGGGGCTGTTCCTATCCCTGCAGCATCTGGG
AATGGAGTGGATGATCTGCAACAGATGATCCAGGCCGTGGTAGATAATGTGTGCTGGCAG
ATGTCCCTGGATCGAAAGACCACTGCACTCAAACAGCTGCAGGGCCACATGTGGAGGGCG
GCATTCACAGCTGGGCGCATGAAAGCAGAGTTCTTTGCAGATGTAGTTCCAGCAGTCAGG
AAGTGGAGAGAGGCCGGAATGAAGGTGTACATCTATTCCTCAGGGAGTGTGGAGGCACAG
AAACTGTTATTCGGGCATTCTACGGAGGGAGATATTCTTGAGCTTGTTGATGGTCACTTT
GATACCAAGATTGGACACAAAGTAGAGAGTGAAAGTTACCGAAAGATTGCAGACAGCATT
GGGTGCTCAACCAACAACATTTTGTTTCTGACAGATGTTACTCGAGAGGCCAGTGCTGCT
GAGGAAGCAGATGTGCACGTAGCTGTGGTGGTGAGACCAGGCAACGCAGGATTAACAGAT
GATGAGAAGACTTACTACAGCCTCATCACATCCTTCAGTGAACTATACCTGCCTTCCTCA
ACCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 28932.44 |
| Theoretical pI
| 4.778 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Enolase-phosphatase E1
MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
DEKTYYSLITSFSELYLPSST
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9UHY7 |
| UniProtKB/Swiss-Prot Entry Name
| ENOPH_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF113125 |
| GeneCard ID
| ENOPH1 |
| GenAtlas ID
| ENOPH1 |
| HGNC ID
| HGNC:24599 |
| References |
|---|
| General References
| Not Available |