Cannabis Compound Database: Showing Protein Dual specificity tyrosine-phosphorylation-regulated kinase 3 (CDBP03922)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03922

Secondary Accession Numbers

Not Available

Name

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Description

Not Available

Synonyms

REDK
Regulatory erythroid kinase

Gene Name

DYRK3

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein kinase activity

Specific Function

Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling

GO Classification

Function
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q32.1

SNPs

DYRK3

Gene Sequence

>1767 bp
ATGGGAGGCACAGCTCGTGGGCCTGGGCGGAAGGATGCGGGGCCGCCTGGGGCCGGGCTC
CCGCCCCAGCAGCGGAGGTTGGGGGATGGTGTCTATGACACCTTCATGATGATAGATGAA
ACCAAATGTCCCCCCTGTTCAAATGTACTCTGCAATCCTTCTGAACCACCTCCACCCAGA
AGACTAAATATGACCACTGAGCAGTTTACAGGAGATCATACTCAGCACTTTTTGGATGGA
GGTGAGATGAAGGTAGAACAGCTGTTTCAAGAATTTGGCAACAGAAAATCCAATACTATT
CAGTCAGATGGCATCAGTGACTCTGAAAAATGCTCTCCTACTGTTTCTCAGGGTAAAAGT
TCAGATTGCTTGAATACAGTAAAATCCAACAGTTCATCCAAGGCACCCAAAGTGGTGCCT
CTGACTCCAGAACAAGCCCTGAAGCAATATAAACACCACCTCACTGCCTATGAGAAACTG
GAAATAATTAATTATCCAGAAATTTACTTTGTAGGTCCAAATGCCAAGAAAAGACATGGA
GTTATTGGTGGTCCCAATAATGGAGGGTATGATGATGCAGATGGGGCCTATATTCATGTA
CCTCGAGACCATCTAGCTTATCGATATGAGGTGCTGAAAATTATTGGCAAGGGGAGTTTT
GGGCAGGTGGCCAGGGTCTATGATCACAAACTTCGACAGTACGTGGCCCTAAAAATGGTG
CGCAATGAGAAGCGCTTTCATCGTCAAGCAGCTGAGGAGATCCGGATTTTGGAGCATCTT
AAGAAACAGGATAAAACTGGTAGTATGAACGTTATCCACATGCTGGAAAGTTTCACATTC
CGGAACCATGTTTGCATGGCCTTTGAATTGCTGAGCATAGACCTTTATGAGCTGATTAAA
AAAAATAAGTTTCAGGGTTTTAGCGTCCAGTTGGTACGCAAGTTTGCCCAGTCCATCTTG
CAATCTTTGGATGCCCTCCACAAAAATAAGATTATTCACTGCGATCTGAAGCCAGAAAAC
ATTCTCCTGAAACACCACGGGCGCAGTTCAACCAAGGTCATTGACTTTGGGTCCAGCTGT
TTCGAGTACCAGAAGCTCTACACATATATCCAGTCTCGGTTCTACAGAGCTCCAGAAATC
ATCTTAGGAAGCCGCTACAGCACACCAATTGACATATGGAGTTTTGGCTGCATCCTTGCA
GAACTTTTAACAGGACAGCCTCTCTTCCCTGGAGAGGATGAAGGAGACCAGTTGGCCTGC
ATGATGGAGCTTCTAGGGATGCCACCACCAAAACTTCTGGAGCAATCCAAACGTGCCAAG
TACTTTATTAATTCCAAGGGCATACCCCGCTACTGCTCTGTGACTACCCAGGCAGATGGG
AGGGTTGTGCTTGTGGGGGGTCGCTCACGTAGGGGTAAAAAGCGGGGTCCCCCAGGCAGC
AAAGACTGGGGGACAGCACTGAAAGGGTGTGATGACTACTTGTTTATAGAGTTCTTGAAA
AGGTGTCTTCACTGGGACCCCTCTGCCCGCTTGACCCCAGCTCAAGCATTAAGACACCCT
TGGATTAGCAAGTCTGTCCCCAGACCTCTCACCACCATAGACAAGGTGTCAGGGAAACGG
GTAGTTAATCCTGCAAGTGCTTTCCAGGGATTGGGTTCTAAGCTGCCTCCAGTTGTTGGA
ATAGCCAATAAGCTTAAAGCTAACTTAATGTCAGAAACCAATGGTAGTATACCCCTATGC
AGTGTATTGCCAAAACTGATTAGCTAG

Protein Properties

Number of Residues

588

Molecular Weight

65713.2

Theoretical pI

9.78

Pfam Domain Function

Pkinase (PF00069 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Dual specificity tyrosine-phosphorylation-regulated kinase 3
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS

External Links

GenBank ID Protein

10441415

UniProtKB/Swiss-Prot ID

O43781

UniProtKB/Swiss-Prot Entry Name

DYRK3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF186773

GeneCard ID