Cannabis Compound Database: Showing Protein m7GpppN-mRNA hydrolase (CDBP03920)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP03920

Secondary Accession Numbers

Not Available

Name

m7GpppN-mRNA hydrolase

Description

Not Available

Synonyms

Nucleoside diphosphate-linked moiety X motif 20
Nudix motif 20
hDpc
mRNA-decapping enzyme 2

Gene Name

DCP2

Protein Type

Enzyme

Biological Properties

General Function

Involved in RNA binding

Specific Function

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety.

GO Classification

Biological Process
gene expression
histone mRNA catabolic process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
cytosol
cytoplasmic mRNA processing body
RNA-induced silencing complex
nucleus
Function
rna binding
manganese ion binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
nucleic acid binding
Molecular Function
exoribonuclease activity, producing 5'-phosphomonoesters
m7G(5')pppN diphosphatase activity
manganese ion binding
RNA binding

Cellular Location

Nucleus
Cytoplasm
P-body

Pathways

Name	SMPDB/Pathwhiz	KEGG
RNA degradation	Not Available

Gene Properties

Chromosome Location

Locus

5q22.2

SNPs

DCP2

Gene Sequence

>1263 bp
ATGGAGACCAAACGGGTGGAGATTCCCGGCAGCGTCCTGGACGATCTCTGCAGCCGATTT
ATTTTGCATATTCCCAGCGAGGAAAGAGACAATGCAATCCGAGTGTGTTTTCAGATTGAA
CTTGCCCATTGGTTTTACTTGGATTTCTACATGCAGAACACACCAGGATTACCTCAGTGT
GGGATAAGAGACTTTGCTAAAGCTGTCTTCAGTCATTGTCCGTTTTTGCTGCCTCAAGGT
GAAGATGTGGAAAAAGTTTTGGATGAATGGAAGGAATATAAAATGGGAGTACCAACATAT
GGTGCAATTATTCTTGATGAGACACTTGAAAATGTACTACTAGTTCAGGGGTACCTAGCA
AAATCAGGCTGGGGATTTCCAAAAGGAAAAGTAAATAAAGAAGAAGCTCCTCATGATTGT
GCTGCTAGAGAGGTCTTTGAAGAAACTGGTTTTGATATCAAAGACTATATTTGTAAGGAT
GATTACATTGAACTTCGAATCAATGACCAGCTTGCTCGTTTGTACATCATTCCAGGAATT
CCAAAAGACACAAAATTTAACCCAAAAACTAGAAGAGAAATTCGGAACATTGAGTGGTTC
TCTATTGAGAAATTGCCTTGTCATAGAAATGATATGACCCCCAAATCCAAACTTGGTTTG
GCACCTAACAAATTTTTTATGGCCATTCCCTTTATCAGACCATTAAGGGACTGGCTTTCT
CGAAGATTTGGCGATTCCTCAGACAGTGACAATGGATTTTCCTCAACTGGTAGCACGCCG
GCTAAACCCACTGTGGAAAAATTGAGTCGAACCAAATTCCGCCACAGTCAGCAGTTATTT
CCTGACGGTTCTCCTGGTGACCAGTGGGTAAAGCACAGGCAACCACTGCAGCAAAAGCCA
TATAATAATCATTCTGAAATGTCTGACCTTTTAAAAGGAAAGAATCAAAGTATGAGGGGA
AATGGCAGAAAACAGTATCAAGATTCACCTAATCAAAAGAAAAGAACAAATGGGCTTCAG
CCAGCAAAGCAGCAGAATTCTTTGATGAAGTGTGAAAAGAAACTTCATCCACGGAAACTT
CAGGATAATTTTGAAACAGATGCTGTATATGACTTGCCTAGCTCCAGTGAAGACCAGTTG
CTAGAACATGCTGAGGGACAGCCCGTGGCATGTAATGGACATTGCAAGTTCCCCTTTTCA
TCCAGAGCCTTTTTGAGTTTCAAGTTTGACCATAATGCTATAATGAAAATCTTGGACCTT
TGA

Protein Properties

Number of Residues

420

Molecular Weight

44408.25

Theoretical pI

6.936

Pfam Domain Function

NUDIX (PF00293 )
DCP2 (PF05026 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>mRNA-decapping enzyme 2
METKRVEIPGSVLDDFCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQC
GIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEYKMGVPTYGAIILDETLENVLLVQGYLA
KSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGI
PKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLS
RRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKP
YNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKL
QDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL

External Links

GenBank ID Protein

31542498

UniProtKB/Swiss-Prot ID

Q8IU60

UniProtKB/Swiss-Prot Entry Name

DCP2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_152624.4

GeneCard ID