| Identification |
|---|
| HMDB Protein ID
| CDBP03918 |
| Secondary Accession Numbers
| Not Available |
| Name
| CCR4-NOT transcription complex subunit 6 |
| Description
| Not Available |
| Synonyms
|
- CCR4 carbon catabolite repression 4-like
- Carbon catabolite repressor protein 4 homolog
- Cytoplasmic deadenylase
|
| Gene Name
| CNOT6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm (Probable)
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q35.3 |
| SNPs
| CNOT6 |
| Gene Sequence
|
>1674 bp
ATGCCCAAAGAAAAATACGAGCCCCCTGACCCTCGGAGGATGTATACAATTATGTCTTCT
GAGGAAGCAGCAAATGGAAAGAAATCCCACTGGGCAGAGCTTGAAATAAGTGGAAAAGTA
AGAAGCTTAAGCGCATCTTTGTGGTCACTAACTCACCTGACAGCTTTGCATTTGAGTGAC
AATTCCCTGTCCCGAATTCCTTCAGACATTGCCAAGCTTCACAATCTGGTGTATTTGGAC
CTGTCATCTAATAAAATTCGTAGCTTACCCGCAGAACTCGGAAACATGGTATCACTCAGG
GAGCTCCATTTAAATAACAACCTGTTACGAGTTCTACCTTTTGAGCTGGGAAAACTGTTT
CAGTTGCAGACTTTAGGCCTGAAAGGAAATCCCCTTACCCAGGATATATTGAACCTTTAT
CAGGAACCAGATGGAACAAGACGGCTGCTGAACTATTTGCTTGATAATTTGTCAGGTACT
GCAAAAAGAATTACAACAGAACAACCACCTCCAAGGTCTTGGATTATGTTACAAGAACCA
GATAGGACAAGGCCAACTGCCTTGTTTTCTGTCATGTGCTATAATGTTCTTTGTGATAAA
TATGCGACCCGGCAGTTATACGGCTACTGTCCATCATGGGCGCTAAACTGGGACTACAGG
AAAAAGGCCATTATTCAAGAAATCTTGAGCTGCAATGCTGATATCGTAAGTCTTCAGGAG
GTTGAAACGGAACAGTATTACAGTTTTTTTCTGGTAGAGCTGAAAGAACGTGGCTATAAT
GGATTCTTCAGTCCTAAGTCTAGAGCTAGGACAATGTCAGAACAAGAAAGGAAACATGTT
GATGGCTGTGCAATATTCTTCAAGACAGAAAAATTTACTTTGGTTCAGAAACACACTGTT
GAATTTAATCAGCTAGCCATGGCAAATTCTGAGGGGTCTGAAGCTATGCTGAACAGAGTC
ATGACAAAAGATAACATTGGGGTTGCAGTACTGCTAGAACTTCGGAAGGAATCGATTGAA
ATGCCGTCTGGAAAGCCACATCTTGGAACAGAAAAACAACTTATTCTTGTGGCTAACGCC
CACATGCATTGGGACCCTGAATACTCTGATGTGAAGTTGGTACAAACTATGATGTTCCTC
TCAGAAGTGAAGAACATTATTGATAAAGCCTCTCGCAACCTCAAATCCAGTGTTTTGGGA
GAATTTGGAACTATTCCACTTGTGTTATGTGCAGATCTTAATTCTTTGCCAGACTCTGGT
GTTGTAGAATATTTGAGCACAGGTGGAGTAGAAACAAATCACAAAGACTTTAAGGAGTTG
AGGTATAATGAAAGTCTCACAAACTTCAGCTGTCATGGGAAGAATGGAACCACCAATGGA
AGGATCACTCATGGTTTCAAGTTACAGAGTGCCTATGAGAGTGGCCTGATGCCTTACACG
AATTACACATTTGATTTCAAGGGTATAATAGACTACATTTTCTATTCTAAACCTCAGCTG
AACACCTTAGGCATCCTGGGCCCTCTGGACCACCACTGGCTGGTTGAGAATAACATCAGT
GGCTGCCCGCACCCCCTCATCCCCTCTGACCACTTCTCACTTTTTGCACAACTGGAGCTC
TTACTGCCTTTCCTGCCCCAAGTCAACGGCATCCACCTTCCTGGCAGGAGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 557 |
| Molecular Weight
| 63306.0 |
| Theoretical pI
| 7.29 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CCR4-NOT transcription complex subunit 6
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD
NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF
QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP
DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE
VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV
EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA
HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG
VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT
NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL
LLPFLPQVNGIHLPGRR
|
| External Links |
|---|
| GenBank ID Protein
| 28872863 |
| UniProtKB/Swiss-Prot ID
| Q9ULM6 |
| UniProtKB/Swiss-Prot Entry Name
| CNOT6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015455.3 |
| GeneCard ID
| CNOT6 |
| GenAtlas ID
| CNOT6 |
| HGNC ID
| HGNC:14099 |
| References |
|---|
| General References
| Not Available |