| Identification |
|---|
| HMDB Protein ID
| CDBP03906 |
| Secondary Accession Numbers
| Not Available |
| Name
| Beta-synuclein |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SNCB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q35 |
| SNPs
| SNCB |
| Gene Sequence
|
>405 bp
ATGGACGTGTTCATGAAGGGCCTGTCCATGGCCAAGGAGGGCGTTGTGGCAGCCGCGGAG
AAAACCAAGCAGGGGGTCACCGAGGCGGCGGAGAAGACCAAGGAGGGCGTCCTTTACGTC
GGAAGCAAGACCCGAGAAGGTGTGGTACAAGGTGTGGCTTCAGTGGCTGAAAAAACCAAG
GAACAGGCCTCACATCTGGGAGGAGCTGTGTTCTCTGGGGCAGGGAACATCGCAGCAGCC
ACAGGACTGGTGAAGAGGGAGGAATTCCCTACTGATCTGAAGCCAGAGGAAGTGGCCCAG
GAAGCTGCTGAAGAACCACTGATTGAGCCCCTGATGGAGCCAGAAGGGGAGAGTTATGAG
GACCCACCCCAGGAGGAATATCAGGAGTATGAGCCAGAGGCGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 134 |
| Molecular Weight
| 14287.8 |
| Theoretical pI
| 4.09 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Beta-synuclein
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK
EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE
DPPQEEYQEYEPEA
|
| External Links |
|---|
| GenBank ID Protein
| 3930222 |
| UniProtKB/Swiss-Prot ID
| Q16143 |
| UniProtKB/Swiss-Prot Entry Name
| SYUB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF053136 |
| GeneCard ID
| SNCB |
| GenAtlas ID
| SNCB |
| HGNC ID
| HGNC:11140 |
| References |
|---|
| General References
| Not Available |