Showing Protein Beta-synuclein (CDBP03906)
| Identification | |||||
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| HMDB Protein ID | CDBP03906 | ||||
| Secondary Accession Numbers | Not Available | ||||
| Name | Beta-synuclein | ||||
| Description | Not Available | ||||
| Synonyms | Not Available | ||||
| Gene Name | SNCB | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Involved in calcium ion binding | ||||
| Specific Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a TP53/p53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease | ||||
| GO Classification |
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| Cellular Location |
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| Pathways | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | Chromosome:5 | ||||
| Locus | 5q35 | ||||
| SNPs | SNCB | ||||
| Gene Sequence |
>405 bp ATGGACGTGTTCATGAAGGGCCTGTCCATGGCCAAGGAGGGCGTTGTGGCAGCCGCGGAG AAAACCAAGCAGGGGGTCACCGAGGCGGCGGAGAAGACCAAGGAGGGCGTCCTTTACGTC GGAAGCAAGACCCGAGAAGGTGTGGTACAAGGTGTGGCTTCAGTGGCTGAAAAAACCAAG GAACAGGCCTCACATCTGGGAGGAGCTGTGTTCTCTGGGGCAGGGAACATCGCAGCAGCC ACAGGACTGGTGAAGAGGGAGGAATTCCCTACTGATCTGAAGCCAGAGGAAGTGGCCCAG GAAGCTGCTGAAGAACCACTGATTGAGCCCCTGATGGAGCCAGAAGGGGAGAGTTATGAG GACCCACCCCAGGAGGAATATCAGGAGTATGAGCCAGAGGCGTAG |
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| Protein Properties | |||||
| Number of Residues | 134 | ||||
| Molecular Weight | 14287.8 | ||||
| Theoretical pI | 4.09 | ||||
| Pfam Domain Function |
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| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Beta-synuclein MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTK EQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYE DPPQEEYQEYEPEA |
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| External Links | |||||
| GenBank ID Protein | 3930222 | ||||
| UniProtKB/Swiss-Prot ID | Q16143 | ||||
| UniProtKB/Swiss-Prot Entry Name | SYUB_HUMAN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | AF053136 | ||||
| GeneCard ID | SNCB | ||||
| GenAtlas ID | SNCB | ||||
| HGNC ID | HGNC:11140 | ||||
| References | |||||
| General References | Not Available | ||||