| Identification |
|---|
| HMDB Protein ID
| CDBP03900 |
| Secondary Accession Numbers
| Not Available |
| Name
| Zinc transporter ZIP14 |
| Description
| Not Available |
| Synonyms
|
- LIV-1 subfamily of ZIP zinc transporter 4
- LZT-Hs4
- Solute carrier family 39 member 14
- ZIP-14
- Zrt- and Irt-like protein 14
|
| Gene Name
| SLC39A14 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in metal ion transmembrane transporter activity |
| Specific Function
| May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake.
|
| GO Classification
|
| Biological Process |
| zinc ion transmembrane import |
| cellular zinc ion homeostasis |
| Cellular Component |
| endoplasmic reticulum |
| Golgi apparatus |
| lamellipodium |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| Function |
| metal ion transmembrane transporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| transporter activity |
| Molecular Function |
| zinc ion transmembrane transporter activity |
| ferrous iron transmembrane transporter activity |
| Process |
| transmembrane transport |
| ion transport |
| cation transport |
| metal ion transport |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein (Potential)
- Cell projection
- lamellipodium
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p21.3 |
| SNPs
| SLC39A14 |
| Gene Sequence
|
>1479 bp
ATGAAGCTGCTGCTGCTGCACCCGGCCTTCCAGAGCTGCCTCCTGCTGACCCTGCTTGGC
TTATGGAGAACCACCCCTGAGGCTCACGCTTCATCCCTGGGTGCACCAGCTATCAGCGCT
GCCTCCTTCCTGCAGGATCTAATACATCGGTATGGCGAGGGTGACAGCCTCACTCTGCAG
CAGCTGAAGGCCCTACTCAACCACCTGGATGTGGGAGTGGGCCGGGGTAATGTCACCCAG
CACGTGCAAGGACACAGGAACCTCTCCACGTGCTTTAGTTCTGGAGACCTCTTCACTGCC
CACAATTTCAGCGAGCAGTCGCGGATTGGGAGCAGCGAGCTCCAGGAGTTCTGCCCCACC
ATCCTCCAGCAGCTGGATTCCCGGGCCTGCACCTCGGAGAACCAGGAAAACGAGGAGAAT
GAGCAGACGGAGGAGGGGCGGCCAAGCGCTGTTGAAGTGTGGGGATACGGTCTCCTCTGT
GTGACCGTCATCTCCCTCTGCTCCCTCCTGGGGGCCAGCGTGGTGCCCTTCATGAAGAAG
ACCTTTTACAAGAGGCTGCTGCTCTACTTCATAGCTCTGGCGATTGGAACCCTCTACTCC
AACGCCCTCTTCCAGCTCATCCCGGAGGCATTTGGTTTCAACCCTCTGGAAGATTATTAT
GTCTCCAAGTCTGCAGTGGTGTTTGGGGGCTTTTATCTTTTCTTTTTCACAGAGAAGATC
TTGAAGATTCTTCTTAAGCAGAAAAATGAGCATCATCATGGACACAGCCATTATGCCTCT
GAGTCGCTTCCCTCCAAGAAGGACCAGGAGGAGGGGGTGATGGAGAAGCTGCAGAACGGG
GACCTGGACCACATGATTCCTCAGCACTGCAGCAGTGAGCTGGACGGCAAGGCGCCCATG
GTGGACGAGAAGGTCATTGTGGGCTCGCTCTCTGTGCAGGACCTGCAGGCTTCCCAGAGT
GCTTGCTACTGGCTGAAAGGTGTCCGCTACTCTGATATCGGCACTCTGGCCTGGATGATC
ACTCTGAGCGACGGCCTCCATAATTTCATCGATGGCCTGGCCATCGGTGCTTCCTTCACT
GTGTCAGTTTTCCAAGGCATCAGCACCTCGGTGGCCATCCTCTGTGAGGAGTTCCCACAT
GAGCTAGGAGACTTTGTCATCCTGCTCAACGCTGGGATGAGCATCCAACAAGCTCTCTTC
TTCAACTTCCTTTCTGCCTGCTGCTGCTACCTGGGTCTGGCCTTTGGCATCCTGGCCGGC
AGCCACTTCTCTGCCAACTGGATTTTTGCGCTAGCTGGAGGAATGTTCTTGTATATTTCT
CTGGCTGATATGTTCCCTGAGATGAATGAGGTCTGTCAAGAGGATGAAAGGAAGGGCAGC
ATCTTGATTCCATTTATCATCCAGAACCTGGGCCTCCTGACTGGATTCACCATCATGGTG
GTCCTCACCATGTATTCAGGACAGATCCAGATTGGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 492 |
| Molecular Weight
| 54211.785 |
| Theoretical pI
| 5.327 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Zinc transporter ZIP14
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSPGAPAISAASFLQDLIHRYGEGDSLTLQ
QLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPT
ILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKK
TFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKI
LKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPM
VDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFT
VSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAG
SHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMV
VLTMYSGQIQIG
|
| External Links |
|---|
| GenBank ID Protein
| 190360568 |
| UniProtKB/Swiss-Prot ID
| Q15043 |
| UniProtKB/Swiss-Prot Entry Name
| S39AE_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001128431.2 |
| GeneCard ID
| SLC39A14 |
| GenAtlas ID
| SLC39A14 |
| HGNC ID
| HGNC:20858 |
| References |
|---|
| General References
| Not Available |