| Identification |
|---|
| HMDB Protein ID
| CDBP03895 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
| Description
| Not Available |
| Synonyms
|
- PP2A-beta
|
| Gene Name
| PPP2CB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
|
| GO Classification
|
| Biological Process |
| response to antibiotic |
| negative regulation of Ras protein signal transduction |
| regulation of gene expression |
| proteasomal ubiquitin-dependent protein catabolic process |
| response to hydrogen peroxide |
| fibroblast growth factor receptor signaling pathway |
| protein dephosphorylation |
| negative regulation of apoptotic process |
| Cellular Component |
| cytosol |
| nucleus |
| chromosome, centromeric region |
| protein phosphatase type 2A complex |
| spindle pole |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- cytoskeleton
- Chromosome
- centromere
- spindle pole
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | mRNA surveillance pathway | Not Available |  | | Oocyte meiosis | Not Available |  | | PI3K-Akt signaling pathway | Not Available |  | | TGF-beta signaling pathway | Not Available |  | | Hippo signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p12 |
| SNPs
| PPP2CB |
| Gene Sequence
|
>930 bp
ATGGACGACAAGGCGTTCACCAAGGAGCTGGACCAGTGGGTCGAGCAGCTGAACGAGTGT
AAGCAGCTGAACGAGAACCAAGTGCGGACGCTGTGCGAGAAGGCAAAGGAAATTTTAACA
AAAGAATCAAATGTGCAAGAGGTTCGTTGCCCTGTTACTGTCTGTGGAGATGTGCATGGT
CAATTTCATGATCTTATGGAACTCTTTAGAATTGGTGGAAAATCACCGGATACAAACTAC
TTATTCATGGGTGACTATGTAGACAGAGGATATTATTCAGTGGAGACTGTGACTCTTCTT
GTAGCATTAAAGGTGCGTTATCCAGAACGCATTACAATATTGAGAGGAAATCACGAAAGC
CGACAAATTACCCAAGTATATGGCTTTTATGATGAATGTCTGCGAAAGTATGGGAATGCC
AACGTTTGGAAATATTTTACAGATCTCTTTGATTATCTTCCACTTACAGCTTTAGTAGAT
GGACAGATATTCTGCCTCCATGGTGGCCTCTCTCCATCCATAGACACACTGGATCATATA
AGAGCCCTGGATCGTTTACAGGAAGTTCCACATGAGGGCCCAATGTGTGATCTGTTATGG
TCAGATCCAGATGATCGTGGTGGATGGGGTATTTCACCACGTGGTGCTGGCTACACATTT
GGACAAGACATTTCTGAAACCTTTAACCATGCCAATGGTCTCACACTGGTTTCTCGTGCC
CACCAGCTTGTAATGGAGGGATACAATTGGTGTCATGATCGGAATGTGGTTACCATTTTC
AGTGCACCCAATTACTGTTATCGTTGTGGGAACCAGGCTGCTATCATGGAATTAGATGAC
ACTTTAAAATATTCCTTCCTTCAATTTGACCCGGCGCCTCGTCGTGGTGAGCCTCATGTT
ACACGGCGCACCCCAGACTACTTCCTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35574.85 |
| Theoretical pI
| 5.426 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
|
| External Links |
|---|
| GenBank ID Protein
| 35581 |
| UniProtKB/Swiss-Prot ID
| P62714 |
| UniProtKB/Swiss-Prot Entry Name
| PP2AB_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X12656 |
| GeneCard ID
| PPP2CB |
| GenAtlas ID
| PPP2CB |
| HGNC ID
| HGNC:9300 |
| References |
|---|
| General References
| Not Available |