| Identification |
|---|
| HMDB Protein ID
| CDBP03880 |
| Secondary Accession Numbers
| Not Available |
| Name
| Beta,beta-carotene 9',10'-oxygenase |
| Description
| Not Available |
| Synonyms
|
- B-diox-II
- Beta-carotene dioxygenase 2
|
| Gene Name
| BCO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.
|
| GO Classification
|
| Biological Process |
| retinoic acid metabolic process |
| carotene catabolic process |
| carotenoid metabolic process |
| regulation of mitochondrial membrane potential |
| regulation of reactive oxygen species metabolic process |
| retinal metabolic process |
| Cellular Component |
| mitochondrion |
| Molecular Function |
| metal ion binding |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q23.1 |
| SNPs
| BCO2 |
| Gene Sequence
|
>1740 bp
ATGTTTTTTCGAGTCTTTCTCCATTTTATCAGGAGTCATTCTGCCACTGCAGTGGATTTC
CTTCCTGTGATGGTGCACCGGCTCCCAGTTTTCAAAAGGTACATGGGAAATACTCCTCAG
AAAAAAGCCGTCTTTGGGCAGTGTCGGGGTCTGCCATGTGTTGCACCGCTGCTGACCACA
GTGGAAGAGGCTCCACGGGGCATCTCTGCTCGAGTCTGGGGACATTTTCCTAAGTGGCTC
AATGGCTCTCTACTTCGAATTGGACCTGGGAAATTCGAGTTTGGGAAGGATAAGTACAAT
CATTGGTTTGATGGGATGGCGCTGCTTCACCAGTTCAGAATGGCAAAGGGCACAGTGACA
TACAGGAGCAAGTTTCTACAGAGTGATACATATAAGGCCAACAGTGCTAAAAACCGAATT
GTGATCTCAGAATTTGGCACACTGGCTCTCCCGGATCCATGCAAGAATGTTTTTGAACGT
TTCATGTCCAGGTTTGAGCTGCCTGGTAAAGCTGCAGCCATGACTGACAATACTAATGTC
AACTATGTGCGGTACAAGGGTGATTACTACCTCTGCACTGAGACCAACTTTATGAATAAA
GTGGACATTGAAACTCTGGAAAAAACAGAAAAGGTAGATTGGAGCAAATTTATTGCTGTG
AATGGAGCAACTGCACATCCTCATTATGACCTGGATGGAACAGCATACAATATGGGGAAC
TCCTTTGGGCCATATGGTTTCTCCTATAAGGTTATTCGGGTTCCTCCAGAGAAGGTGGAC
CTTGGGGAGACAATCCATGGAGTCCAGGTGATATGTTCTATTGCTTCTACAGAGAAAGGG
AAACCTTCTTACTACCATAGCTTTGGAATGACAAGGAACTATATAATTTTCATTGAACAA
CCTCTAAAGATGAACCTGTGGAAAATTGCCACTTCTAAAATTCGGGGAAAGGCCTTTTCA
GATGGGATAAGCTGGGAACCCCAGTGTAATACGCGGTTTCATGTGGTGGAAAAACGCACT
GGACAGCTCCTTCCAGGGAGATACTACAGCAAACCTTTTGTTACATTTCATCAAATCAAT
GCCTTTGAGGACCAGGGCTGTGTTATAATTGATTTGTGCTGTCAAGATAATGGAAGAACC
CTAGAAGTTTACCAGTTACAGAATCTCAGGAAGGCTGGGGAAGGGCTTGATCAGGTCCAT
AATTCAGCAGCCAAATCTTTCCCTCGAAGGTTTGTTTTGCCTTTAAATGTCAGTTTGAAT
GCCCCTGAGGGAGACAACCTGAGTCCATTGTCCTATACTTCAGCCAGTGCTGTGAAACAG
GCTGATGGAACGATCTGGTGCTCTCATGAAAATCTACATCAGGAGGACCTAGAAAAGGAA
GGAGGCATTGAATTTCCTCAGATCTACTATGATCGATTCAGTGGCAAAAAGTATCATTTC
TTTTATGGCTGTGGCTTTCGGCATTTAGTGGGGGATTCTCTGATCAAGGTTGATGTGGTG
AATAAGACACTGAAGGTTTGGAGAGAAGATGGCTTTTATCCCTCAGAACCTGTTTTTGTT
CCAGCACCAGGAACCAATGAAGAAGATGGTGGGGTTATTCTTTCTGTGGTGATCACTCCC
AACCAGAATGAAAGCAATTTTATCCTAGTTTTGGATGCCAAGAACTTTGAAGAGCTGGGC
CGAGCAGAGGTACCTGTGCAGATGCCTTATGGGTTCCATGGTACCTTCATACCCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 579 |
| Molecular Weight
| 61509.65 |
| Theoretical pI
| 7.964 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Beta,beta-carotene 9',10'-oxygenase
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTT
VEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVT
YRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNV
NYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDLDGTAYNMGN
SFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQ
PLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQIN
AFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLN
APEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHF
FYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITP
NQNESNFILVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
|
| External Links |
|---|
| GenBank ID Protein
| 82617624 |
| UniProtKB/Swiss-Prot ID
| Q9BYV7 |
| UniProtKB/Swiss-Prot Entry Name
| BCDO2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_031938.4 |
| GeneCard ID
| BCO2 |
| GenAtlas ID
| BCO2 |
| HGNC ID
| HGNC:18503 |
| References |
|---|
| General References
| Not Available |