| Identification |
|---|
| HMDB Protein ID
| CDBP03878 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 |
| Description
| Not Available |
| Synonyms
|
- Alkylated DNA repair protein alkB homolog 2
- Oxy DC1
- DNA oxidative demethylase ALKBH2
|
| Gene Name
| ALKBH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
|
| GO Classification
|
| Biological Process |
| DNA dealkylation involved in DNA repair |
| oxidative DNA demethylation |
| Cellular Component |
| nucleoplasm |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| ferrous iron binding |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| cytosine C-5 DNA demethylase activity |
| DNA-N1-methyladenine dioxygenase activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.11 |
| SNPs
| ALKBH2 |
| Gene Sequence
|
>786 bp
ATGGACAGATTCCTGGTGAAAGGGGCTCAAGGGGGCCTTTTGAGGAAGCAGGAGGAGCAA
GAGCCAACTGGAGAAGAGCCAGCTGTGTTGGGAGGAGACAAAGAAAGCACAAGGAAGAGG
CCCAGGGGAGAGGCCCCAGGGAATGGAGGCCACTCAGCAGGCCCTAGCTGGCGGCACATT
CGGGCTGAGGGCCTGGACTGCAGTTACACAGTCCTGTTTGGCAAAGCTGAGGCAGATGAG
ATTTTCCAAGAGTTGGAGAAAGAAGTAGAATATTTTACAGGAGCACTGGCCAGAGTCCAG
GTATTCGGGAAGTGGCACAGTGTGCCCAGGAAGCAAGCAACGTATGGCGACGCTGGGCTG
ACCTACACATTTTCAGGCCTCACGCTGTCTCCAAAGCCCTGGATCCCAGTTCTAGAGCGC
ATCCGGGATCACGTCTCTGGGGTGACTGGACAGACCTTCAACTTTGTGCTCATCAACAGG
TATAAAGATGGCTGTGACCACATCGGGGAGCACCGAGATGATGAAAGAGAACTGGCCCCT
GGGAGCCCCATTGCCTCTGTCTCCTTCGGTGCCTGCAGAGACTTTGTCTTCCGGCATAAG
GATTCCCGTGGGAAAAGCCCCTCCAGGAGGGTGGCGGTGGTCAGGCTGCCGCTGGCCCAC
GGGAGCTTACTAATGATGAACCACCCGACCAACACGCACTGGTACCACAGTCTTCCCGTG
AGAAAGAAGGTTCTGGCTCCACGGGTGAATCTGACTTTTCGTAAAATTTTGCTTACTAAA
AAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 29322.22 |
| Theoretical pI
| 9.652 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHI
RAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGL
TYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAP
GSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPV
RKKVLAPRVNLTFRKILLTKK
|
| External Links |
|---|
| GenBank ID Protein
| 53988530 |
| UniProtKB/Swiss-Prot ID
| Q6NS38 |
| UniProtKB/Swiss-Prot Entry Name
| ALKB2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AY754389 |
| GeneCard ID
| ALKBH2 |
| GenAtlas ID
| ALKBH2 |
| HGNC ID
| HGNC:32487 |
| References |
|---|
| General References
| Not Available |