| Identification |
|---|
| HMDB Protein ID
| CDBP03870 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neudesin |
| Description
| Not Available |
| Synonyms
|
- Cell immortalization-related protein 2
- Neuron-derived neurotrophic factor
- SPUF protein
- Secreted protein of unknown function
|
| Gene Name
| NENF |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in heme binding |
| Specific Function
| Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| iron ion binding |
| heme binding |
|
| Cellular Location
|
- Secreted
- extracellular space
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q32.3 |
| SNPs
| NENF |
| Gene Sequence
|
>519 bp
ATGGTGGGCCCCGCGCCGCGGCGGCGGCTGCGGCCGCTGGCAGCGCTGGCCCTGGTCCTG
GCGCTGGCCCCGGGGCTGCCCACAGCCCGGGCCGGGCAGACACCGCGCCCTGCCGAGCGG
GGGCCCCCAGTGCGGCTTTTCACCGAGGAGGAGCTGGCCCGCTATGGCGGGGAGGAGGAA
GATCAGCCCATCTACTTGGCAGTGAAGGGAGTGGTGTTTGATGTCACCTCCGGAAAGGAG
TTTTATGGACGAGGAGCCCCCTACAATGCCTTGACGGGGAAGGACTCCACTAGAGGGGTA
GCCAAGATGTCCTTGGATCCTGCAGACCTCACCCATGACACTACGGGTCTCACGGCCAAG
GAACTGGAGGCCCTGGATGAGGTCTTCACCAAAGTGTACAAAGCCAAATACCCCATCGTC
GGCTACACTGCCCGGAGAATTCTCAATGAGGATGGCAGCCCTAACCTGGACTTCAAGCCT
GAAGACCAGCCCCATTTTGACATCAAGGATGAGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 18856.2 |
| Theoretical pI
| 5.36 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Neudesin
MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPVRLFTEEELARYGGEEE
DQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAK
ELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
|
| External Links |
|---|
| GenBank ID Protein
| 55771070 |
| UniProtKB/Swiss-Prot ID
| Q9UMX5 |
| UniProtKB/Swiss-Prot Entry Name
| NENF_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB126219 |
| GeneCard ID
| NENF |
| GenAtlas ID
| NENF |
| HGNC ID
| HGNC:30384 |
| References |
|---|
| General References
| Not Available |