| Identification |
|---|
| HMDB Protein ID
| CDBP03869 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mitoferrin-2 |
| Description
| Not Available |
| Synonyms
|
- MRS3/4
- Mitochondrial RNA-splicing protein 3/4 homolog
- Mitochondrial iron transporter 2
- Solute carrier family 25 member 28
- hMRS3/4
|
| Gene Name
| SLC25A28 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| binding |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q24.2 |
| SNPs
| SLC25A28 |
| Gene Sequence
|
>1095 bp
ATGGAGTTGGAGGGGCGGGGTGCTGGCGGTGTGGCGGGGGGGCCGGCGGCAGGGCCCGGG
CGGAGCCCCGGGGAGTCGGCGCTGCTGGACGGGTGGCTGCAGCGGGGCGTGGGCCGGGGG
GCCGGCGGCGGGGAGGCCGGGGCCTGCAGGCCCCCGGTACGACAAGATCCGGACTCCGGC
CCGGACTACGAGGCGCTGCCGGCTGGAGCCACTGTCACCACGCACATGGTGGCAGGCGCC
GTGGCAGGGATCCTGGAGCACTGCGTGATGTACCCCATCGACTGCGTCAAGACCCGGATG
CAGAGTCTACAGCCTGACCCAGCTGCCCGCTATCGCAATGTGTTGGAGGCCCTCTGGAGG
ATTATAAGAACGGAGGGCCTATGGAGGCCCATGAGGGGGCTGAACGTCACAGCAACAGGC
GCAGGGCCTGCCCACGCCCTTTATTTTGCCTGCTACGAAAAGTTAAAAAAGACATTGAGT
GATGTAATCCACCCTGGGGGCAATAGCCATATTGCCAATGGTGCGGCCGGGTGTGTGGCA
ACATTACTTCATGATGCAGCCATGAACCCTGCGGAAGTGGTCAAGCAGAGGATGCAGATG
TACAACTCACCATACCACCGGGTGACAGACTGTGTACGGGCAGTGTGGCAAAATGAAGGG
GCCGGGGCCTTTTACCGCAGCTACACCACCCAGCTGACCATGAACGTTCCTTTCCAAGCC
ATTCACTTCATGACCTATGAATTCCTGCAGGAGCACTTTAACCCCCAGAGACGGTACAAC
CCAAGCTCCCACGTCCTCTCTGGAGCTTGCGCAGGAGCTGTAGCTGCCGCAGCCACAACC
CCACTGGACGTTTGCAAAACACTGCTCAACACCCAGGAGTCCTTGGCTTTGAACTCACAC
ATTACAGGACATATCACAGGCATGGCTAGTGCCTTCAGGACGGTATATCAAGTAGGTGGG
GTGACCGCCTATTTCCGAGGGGTGCAGGCCAGAGTAATTTACCAGATCCCCTCCACAGCC
ATCGCATGGTCTGTGTATGAGTTCTTCAAATACCTAATCACTAAAAGGCAAGAAGAGTGG
AGGGCTGGCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 364 |
| Molecular Weight
| 39271.5 |
| Theoretical pI
| 8.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["72-91", "133-152", "170-189", "227-246", "261-280", "327-346"]
|
| Protein Sequence
|
>Mitoferrin-2
MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG
PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR
IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA
TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA
IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH
ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW
RAGK
|
| External Links |
|---|
| GenBank ID Protein
| 149274643 |
| UniProtKB/Swiss-Prot ID
| Q96A46 |
| UniProtKB/Swiss-Prot Entry Name
| MFRN2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_031212.3 |
| GeneCard ID
| SLC25A28 |
| GenAtlas ID
| SLC25A28 |
| HGNC ID
| HGNC:23472 |
| References |
|---|
| General References
| Not Available |