| Identification |
|---|
| HMDB Protein ID
| CDBP03868 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mitoferrin-1 |
| Description
| Not Available |
| Synonyms
|
- Mitochondrial iron transporter 1
- Mitochondrial solute carrier protein
- Solute carrier family 25 member 37
|
| Gene Name
| SLC25A37 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| binding |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p21.2 |
| SNPs
| SLC25A37 |
| Gene Sequence
|
>1017 bp
ATGGAGCTGCGCAGCGGGAGCGTGGGCAGCCAGGCGGTGGCGCGGAGGATGGATGGGGAC
AGCCGAGATGGCGGCGGCGGCAAGGACGCCACCGGGTCGGAGGACTACGAGAACCTGCCG
ACTAGCGCCTCCGTGTCCACCCACATGACAGCAGGAGCGATGGCCGGGATCCTGGAGCAC
TCGGTCATGTACCCGGTGGACTCGGTGAAGACACGAATGCAGAGTTTGAGTCCAGATCCC
AAAGCCCAGTACACAAGTATCTACGGAGCCCTCAAGAAAATCATGCGGACCGAAGGCTTC
TGGAGGCCCTTGCGAGGCGTCAACGTCATGATCATGGGTGCAGGGCCGGCCCATGCCATG
TATTTTGCCTGCTATGAAAACATGAAAAGGACTTTAAATGACGTTTTCCACCACCAAGGA
AACAGCCACCTAGCCAACGGGATAGCTGGGAGTATGGCCACCCTGCTCCACGATGCGGTA
ATGAATCCAGCAGAAGTGGTGAAGCAGCGCTTGCAGATGTACAACTCGCAGCACCGGTCA
GCAATCAGCTGCATCCGGACGGTGTGGAGGACCGAGGGGTTGGGGGCCTTCTACCGGAGC
TACACCACGCAGCTGACCATGAACATCCCCTTCCAGTCCATCCACTTCATCACCTATGAG
TTCCTGCAGGAGCAGGTCAACCCCCACCGGACCTACAACCCGCAGTCCCACATCATCTCA
GGCGGGCTGGCCGGGGCCCTCGCCGCGGCCGCCACGACCCCCCTGGACGTCTGTAAGACC
CTTCTGAACACTCAGGAGAACGTGGCCCTCTCGCTGGCCAACATCAGCGGCCGGCTGTCG
GGTATGGCCAATGCCTTCCGGACGGTGTACCAGCTCAACGGCCTGGCCGGCTACTTCAAA
GGCATCCAGGCGCGTGTCATCTACCAGATGCCCTCCACCGCCATTTCTTGGTCTGTCTAT
GAGTTCTTCAAGTACTTTCTCACCAAGCGCCAGCTGGAAAATCGAGCTCCATACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 338 |
| Molecular Weight
| 37322.3 |
| Theoretical pI
| 9.55 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["45-64", "106-125", "143-162", "200-219", "234-253", "301-320"]
|
| Protein Sequence
|
>Mitoferrin-1
MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEH
SVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAM
YFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRS
AISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIIS
GGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFK
GIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY
|
| External Links |
|---|
| GenBank ID Protein
| 82775373 |
| UniProtKB/Swiss-Prot ID
| Q9NYZ2 |
| UniProtKB/Swiss-Prot Entry Name
| MFRN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016612.2 |
| GeneCard ID
| SLC25A37 |
| GenAtlas ID
| SLC25A37 |
| HGNC ID
| HGNC:29786 |
| References |
|---|
| General References
| Not Available |