Showing Protein Ferric-chelate reductase 1 (CDBP03858)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03858
Secondary Accession Numbers Not Available
Name Ferric-chelate reductase 1
Description Not Available
Synonyms
  1. SDR-2
  2. Stromal cell-derived receptor 2
Gene Name FRRS1
Protein Type Enzyme
Biological Properties
General Function Involved in dopamine beta-monooxygenase activity
Specific Function Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm
GO Classification
Function
catalytic activity
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
dopamine beta-monooxygenase activity
Process
metabolic process
cellular metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
histidine family amino acid metabolic process
histidine metabolic process
histidine catabolic process
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p21.2
SNPs FRRS1
Gene Sequence 
>1881 bp
ATGGCAGTTTCTGGATTTACTCTTGGTACCTGCATACTTCTGTTGCACATTAGTTATGTG
GCTAATTATCCCAATGGAAAAGTAACACAGTCATGCCATGGAATGATTCCTGAACATGGT
CATAGTCCACAGTCTGTTCCTGTTCATGACATTTACGTGAGTCAGATGACATTCAGGCCA
GGAGATCAGATTGAAGTTACTTTGTCAGGGCATCCATTTAAAGGCTTTCTCCTAGAAGCG
CGTAATGCTGAGGATCTGAATGGCCCTCCTATTGGCTCCTTCACATTGATTGACAGTGAA
GTGTCACAACTTTTGACCTGTGAAGATATACAGGGATCAGCAGTGAGTCACAGAAGTGCA
TCTAAAAAAACAGAAATTAAAGTCTACTGGAATGCTCCAAGCAGTGCTCCAAATCACACA
CAGTTTCTAGTCACAGTTGTTGAGAAGTATAAAATCTACTGGGTGAAGATTCCTGGTCCT
ATAATTTCACAACCAAATGCATTTCCTTTTACAACACCTAAAGCTACAGTAGTACCTTTG
CCAACGTTACCTCCCGTTTCCCACTTAACCAAACCATTCAGTGCCTCAGATTGTGGGAAC
AAGAAGTTCTGTATTAGGAGTCCTTTGAACTGTGACCCAGAGAAGGAGGCTTCCTGTGTC
TTCTTGTCCTTCACAAGAGATGACCAATCGGTGATGGTTGAAATGAGCGGCCCCAGTAAA
GGCTATTTATCCTTTGCATTGTCTCATGATCAGTGGATGGGTGATGATGATGCTTATCTG
TGTATTCATGAAGATCAGACTGTGTACATCCAGCCTTCCCATTTAACGGGGCGAAGTCAC
CCTGTAATGGACTCCAGGGATACCCTTGAGGATATGGCTTGGAGGTTGGCGGACGGTGTT
ATGCAGTGTTCTTTCAGAAGAAACATTACCCTTCCTGGAGTTAAGAATAGATTTGATCTA
AACACAAGCTATTACATATTTCTAGCAGATGGTGCAGCTAATGATGGTCGAATTTACAAG
CACTCTCAGCAACCTTTGATTACCTATGAAAAATATGATGTGACAGACTCTCCAAAGAAC
ATAGGAGGATCCCATTCTGTACTCCTTCTGAAGGTTCATGGTGCCTTAATGTTTGTGGCA
TGGATGACTACTGTTAGCATAGGTGTACTGGTTGCCCGGTTCTTCAAGCCAGTTTGGTCA
AAAGCTTTCTTGCTTGGTGAAGCAGCTTGGTTTCAGGTGCATCGGATGCTCATGTTCACC
ACAACTGTCCTCACCTGCATTGCTTTTGTTATGCCGTTTATATACAGGGGAGGCTGGAGT
AGGCATGCAGGTTACCACCCATACCTCGGCTGTATAGTGATGACTTTGGCAGTTCTTCAG
CCTCTTCTGGCAGTCTTCAGGCCACCTTTACATGACCCAAGAAGGCAAATGTTTAACTGG
ACTCATTGGAGTATGGGAACAGCTGCTAGAATAATAGCAGTGGCAGCGATGTTCCTGGGA
ATGGATTTACCAGGACTGAATCTTCCTGATTCATGGAAAACCTATGCAATGACCGGATTC
GTAGCCTGGCATGTTGGGACTGAGGTTGTTCTGGAGTTGAAATATTGGATGATGACAGAA
TTCAGATCCTTCAGTCATTTACTGCAGTGGAAACAGAGGGTCATGCTTTTAAAAAGGCAG
TGTTGGCAATTTATGTCTGTGGGAATGTTACTTTTCTCATCATATTTTTATCTGCAATCA
ACCATCTATGAGCAAGCAAAGACCTTGGCTTTTGCAGGCCAAGTGATAATTATCATCAAA
CCAAAGAAACTTGAAGCCTGTCCTGACTGCCTGGAGCATATTTGTGAATTCTCACTTGGA
AGACTGGGGTCATGTCTGTAG
Protein Properties
Number of Residues 592
Molecular Weight 66113.9
Theoretical pI 7.51
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["2-22", "372-392", "415-435", "446-466", "491-511", "515-535", "569-589"]
Protein Sequence 
>Ferric-chelate reductase 1
MAVSGFTLGTCILLLHISYVANYPNGKVTQSCHGMIPEHGHSPQSVPVHDIYVSQMTFRP
GDQIEVTLSGHPFKGFLLEARNAEDLNGPPIGSFTLIDSEVSQLLTCEDIQGSAVSHRSA
SKKTEIKVYWNAPSSAPNHTQFLVTVVEKYKIYWVKIPGPIISQPNAFPFTTPKATVVPL
PTLPPVSHLTKPFSASDCGNKKFCIRSPLNCDPEKEASCVFLSFTRDDQSVMVEMSGPSK
GYLSFALSHDQWMGDDDAYLCIHEDQTVYIQPSHLTGRSHPVMDSRDTLEDMAWRLADGV
MQCSFRRNITLPGVKNRFDLNTSYYIFLADGAANDGRIYKHSQQPLITYEKYDVTDSPKN
IGGSHSVLLLKVHGALMFVAWMTTVSIGVLVARFFKPVWSKAFLLGEAAWFQVHRMLMFT
TTVLTCIAFVMPFIYRGGWSRHAGYHPYLGCIVMTLAVLQPLLAVFRPPLHDPRRQMFNW
THWSMGTAARIIAVAAMFLGMDLPGLNLPDSWKTYAMTGFVAWHVGTEVVLEVHAYRLSR
KVEILDDDRIQILQSFTAVETEGHAFKKAVLAIYVCGNVTFLIIFLSAINHL
GenBank ID Protein 147900821
UniProtKB/Swiss-Prot ID Q6ZNA5
UniProtKB/Swiss-Prot Entry Name FRRS1_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID FRRS1
GenAtlas ID FRRS1
HGNC ID HGNC:27622
References
General References Not Available