| Identification |
| HMDB Protein ID
| CDBP03838 |
| Secondary Accession Numbers
| Not Available |
| Name
| ATP-binding cassette sub-family B member 10, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- ABC transporter 10 protein
- ATP-binding cassette transporter 10
- M-ABC2
- Mitochondrial ATP-binding cassette 2
|
| Gene Name
| ABCB10 |
| Protein Type
| Transporter |
| Biological Properties |
| General Function
| Involved in ATP binding |
| Specific Function
| May mediate critical mitochondrial transport functions related to heme biosynthesis |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| atpase activity, coupled to transmembrane movement of substances |
| pyrophosphatase activity |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| transmembrane transporter activity |
| atpase activity |
| transporter activity |
| nucleoside-triphosphatase activity |
| active transmembrane transporter activity |
| primary active transmembrane transporter activity |
| hydrolase activity, acting on acid anhydrides |
| p-p-bond-hydrolysis-driven transmembrane transporter activity |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.13 |
| SNPs
| ABCB10 |
| Gene Sequence
|
>2217 bp
ATGCGAGGCCCCCCTGCCTGGCCGCTGCGGCTGCTCGAGCCACCGAGCCCTGCCGAGCCA
GGTCGGCTCCTGCCGGTAGCCTGCGTGTGGGCCGCGGCCAGCCGCGTTCCCGGGTCCCTA
TCGCCGTTCACTGGCCTGAGGCCGGCGCGGCTATGGGGCGCGGGGCCCGCGCTGCTCTGG
GGCGTTGGAGCCGCGCGCCGCTGGAGGAGCGGCTGCCGGGGCGGGGGTCCGGGCGCCTCG
CGGGGCGTCCTGGGCCTCGCGCGGCTCCTGGGGCTGTGGGCTCGCGGCCCCGGCAGCTGC
AGGTGCGGGGCTTTTGCCGGGCCAGGCGCTCCTCGGCTCCCGCGCGCCCGGTTCCCGGGC
GGTCCCGCAGCCGCTGCCTGGGCAGGGGACGAGGCCTGGCGGCGCGGGCCGGCGGCGCCT
CCCGGGGACAAGGGGCGGCTGCGCCCCGCAGCGGCCGGACTCCCGGAGGCCCGGAAGCTC
CTGGGGCTGGCGTACCCTGAGCGCCGGAGGCTGGCAGCTGCGGTTGGATTTCTCACGATG
TCCAGTGTTATCTCCATGTCTGCCCCTTTCTTCCTGGGGAAGATCATTGATGTCATCTAT
ACCAACCCCACTGTGGACTACAGCGACAACCTGACCCGCCTCTGCCTAGGGCTCAGTGCC
GTGTTTCTGTGTGGTGCTGCCGCCAATGCCATTCGTGTCTACCTCATGCAAACTTCAGGT
CAGCGCATTGTGAATAGGCTGAGAACTTCATTATTCTCCTCCATTCTGAGGCAGGAGGTT
GCTTTCTTTGACAAGACTCGCACAGGAGAATTGATTAACCGCCTCTCATCAGACACTGCA
CTCCTGGGGCGCTCAGTGACTGAAAACCTCTCAGATGGGCTCAGGGCCGGGGCCCAGGCT
TCCGTAGGCATCAGTATGATGTTTTTTGTCTCACCTAATCTGGCCACCTTTGTTTTGAGC
GTGGTGCCTCCAGTGTCAATCATTGCTGTAATTTATGGGCGATATCTACGGAAACTGACC
AAAGTCACTCAGGATTCCCTGGCACAAGCCACTCAGCTAGCTGAGGAACGTATTGGAAAT
GTAAGAACTGTTCGAGCTTTTGGGAAAGAAATGACTGAAATCGAGAAATATGCCAGCAAA
GTGGACCATGTAATGCAGTTAGCAAGGAAAGAGGCATTCGCCCGGGCTGGTTTCTTTGGA
GCAACTGGGCTCTCCGGAAACCTGATCGTGCTTTCTGTCCTGTACAAAGGAGGGCTGCTG
ATGGGCAGTGCCCACATGACCGTGGGTGAACTCTCTTCCTTCCTAATGTATGCTTTCTGG
GTTGGAATAAGCATTGGAGGTCTGAGCTCTTTCTACTCGGAGCTGATGAAAGGACTGGGT
GCAGGGGGGCGCCTCTGGGAGCTCCTGGAGAGAGAGCCCAAGCTGCCTTTTAACGAGGGG
GTCATCTTAAATGAGAAAAGCTTCCAGGGTGCTTTGGAGTTTAAGAACGTGCATTTTGCC
TATCCAGCTCGCCCAGAGGTGCCCATATTTCAGGATTTCAGCCTTTCCATTCCGTCAGGA
TCTGTCACGGCACTGGTTGGCCCAAGTGGTTCTGGCAAATCAACAGTGCTTTCACTCCTG
CTGAGGTTGTACGACCCTGCTTCTGGAACTATTAGTCTTGATGGCCATGACATCCGTCAG
CTAAACCCAGTGTGGCTGAGATCCAAAATTGGGACAGTGAGTCAGGAACCCATTTTGTTT
TCTTGCTCTATTGCTGAGAACATTGCTTATGGTGCTGATGACCCTTCCTCTGTGACCGCT
GAGGAAATCCAGAGAGTGGCTGAAGTGGCCAATGCAGTGGCCTTCATCCGGAATTTCCCC
CAAGGGTTCAACACTGTGGTTGGAGAAAAGGGTGTTCTCCTCTCAGGTGGGCAGAAACAG
CGGATTGCGATTGCCCGTGCTCTGCTAAAGAATCCCAAAATTCTTCTCCTAGATGAAGCA
ACCAGTGCGCTGGATGCCGAAAATGAGTACCTTGTTCAAGAAGCTCTAGATCGACTGATG
GATGGAAGAACGGTGTTAGTTATTGCCCATCGTCTGTCCACCATTAAGAATGCTAATATG
GTTGCTGTTCTTGACCAAGGAAAAATTACTGAATATGGAAAACATGAAGAGCTGCTTTCA
AAACCAAATGGGATATACAGAAAACTAATGAACAAACAAAGTTTTATTTCAGCATAA
|
| Protein Properties |
| Number of Residues
| 738 |
| Molecular Weight
| 79146.9 |
| Theoretical pI
| 10.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["171-191", "216-236", "313-333", "408-428", "431-451"]
|
| Protein Sequence
|
>ATP-binding cassette sub-family B member 10, mitochondrial
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW
GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG
GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM
SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG
QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN
VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL
MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG
VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL
LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA
TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS
KPNGIYRKLMNKQSFISA
|
| External Links |
| GenBank ID Protein
| 171184400 |
| UniProtKB/Swiss-Prot ID
| Q9NRK6 |
| UniProtKB/Swiss-Prot Entry Name
| ABCBA_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012089.2 |
| GeneCard ID
| ABCB10 |
| GenAtlas ID
| ABCB10 |
| HGNC ID
| HGNC:41 |
| References |
| General References
| Not Available |