Cannabis Compound Database: Showing Protein ATP-binding cassette sub-family B member 6, mitochondrial (CDBP03836)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03836

Secondary Accession Numbers

Not Available

Name

ATP-binding cassette sub-family B member 6, mitochondrial

Description

Not Available

Synonyms

Mitochondrial ABC transporter 3
Mt-ABC transporter 3
P-glycoprotein-related protein
Ubiquitously-expressed mammalian ABC half transporter

Gene Name

ABCB6

Protein Type

Transporter

Biological Properties

General Function

Involved in ATP binding

Specific Function

Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis

GO Classification

Component
membrane part
intrinsic to membrane
integral to membrane
cell part
Function
transmembrane transporter activity
atpase activity
transporter activity
nucleoside-triphosphatase activity
active transmembrane transporter activity
hydrolase activity, acting on acid anhydrides
primary active transmembrane transporter activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
p-p-bond-hydrolysis-driven transmembrane transporter activity
pyrophosphatase activity
atpase activity, coupled to transmembrane movement of substances
binding
nucleotide binding
catalytic activity
hydrolase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Process
establishment of localization
transport
transmembrane transport

Cellular Location

Multi-pass membrane protein
Mitochondrion outer membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2q36

SNPs

ABCB6

Gene Sequence

>2529 bp
ATGGTGACTGTGGGCAACTACTGCGAGGCCGAAGGGCCCGTGGGTCCGGCCTGGATGCAG
GATGGCCTGAGTCCCTGCTTCTTCTTCACGCTCGTGCCCTCGACGCGGATGGCTCTAGGG
ACTCTGGCCTTGGTGCTGGCTCTTCCCTGCAGACGCCGGGAGCGGCCCGCTGGTGCTGAT
TCGCTGTCTTGGGGGGCCGGCCCTCGCATCTCTCCCTACGTGCTGCAGCTGCTTCTGGCC
ACACTTCAGGCGGCGCTGCCCCTGGCCGGCCTGGCTGGCCGGGTGGGCACTGCCCGGGGG
GCCCCACTGCCAAGCTATCTACTTCTGGCCTCCGTGCTGGAGAGTCTGGCCGGCGCCTGT
GGCCTGTGGCTGCTTGTCGTGGAGCGGAGCCAGGCACGGCAGCGTCTGGCAATGGGCATC
TGGATCAAGTTCAGGCACAGCCCTGGTCTCCTGCTCCTCTGGACTGTGGCGTTTGCAGCT
GAGAACTTGGCCCTGGTGTCTTGGAACAGCCCACAGTGGTGGTGGGCAAGGGCAGACTTG
GGCCAGCAGGTTCAGTTTAGCCTGTGGGTGCTGCGGTATGTGGTCTCTGGAGGGCTGTTT
GTCCTGGGTCTCTGGGCCCCTGGACTTCGTCCCCAGTCCTATACATTGCAGGTTCATGAA
GAGGACCAAGATGTGGAAAGGAGCCAGGTTCGGTCAGCAGCCCAACAGTCTACCTGGCGA
GATTTTGGCAGGAAGCTCCGCCTCCTGAGTGGCTACCTGTGGCCTCGAGGGAGTCCAGCT
CTGCAGCTGGTGGTGCTCATCTGCCTGGGGCTCATGGGTTTGGAACGGGCACTCAATGTG
TTGGTGCCTATATTCTATAGGAACATTGTGAACTTGCTGACTGAGAAGGCACCTTGGAAC
TCTCTGGCCTGGACTGTTACCAGTTACGTCTTCCTCAAGTTCCTCCAGGGGGGTGGCACT
GGCAGTACAGGCTTCGTGAGCAACCTGCGCACCTTCCTGTGGATCCGGGTGCAGCAGTTC
ACGTCTCGGCGGGTGGAGCTGCTCATCTTCTCCCACCTGCACGAGCTCTCACTGCGCTGG
CACCTGGGGCGCCGCACAGGGGAGGTGCTGCGGATCGCGGATCGGGGCACATCCAGTGTC
ACAGGGCTGCTCAGCTACCTGGTGTTCAATGTCATCCCCACGCTGGCCGACATCATCATT
GGCATCATCTACTTCAGCATGTTCTTCAACGCCTGGTTTGGCCTCATTGTGTTCCTGTGC
ATGAGTCTTTACCTCACCCTGACCATTGTGGTCACTGAGTGGAGGACCAAGTTTCGTCGT
GCTATGAACACACAGGAGAACGCTACCCGGGCACGAGCAGTGGACTCTCTGCTAAACTTC
GAGACGGTGAAGTATTACAACGCCGAGAGTTACGAAGTGGAACGCTATCGAGAGGCCATC
ATCAAATATCAGGGTTTGGAGTGGAAGTCGAGCGCTTCACTGGTTTTACTAAATCAGACC
CAGAACCTGGTGATTGGGCTCGGGCTCCTCGCCGGCTCCCTGCTTTGCGCATACTTTGTC
ACTGAGCAGAAGCTACAGGTTGGGGACTATGTGCTCTTTGGCACCTACATTATCCAGCTG
TACATGCCCCTCAATTGGTTTGGCACCTACTACAGGATGATCCAGACCAACTTCATTGAC
ATGGAGAACATGTTTGACTTGCTGAAAGAGGAGACAGAAGTGAAGGACCTTCCTGGAGCA
GGGCCCCTTCGCTTTCAGAAGGGCCGTATTGAGTTTGAGAACGTGCACTTCAGCTATGCC
GATGGGCGGGAGACTCTGCAGGACGTGTCTTTCACTGTGATGCCTGGACAGACACTTGCC
CTGGTGGGCCCATCTGGGGCAGGGAAGAGCACAATTTTGCGCCTGCTGTTTCGCTTCTAC
GACATCAGCTCTGGCTGCATCCGAATAGATGGGCAGGACATTTCACAGGTGACCCAGGCC
TCTCTCCGGTCTCACATTGGAGTTGTGCCCCAAGACACTGTCCTCTTTAATGACACCATC
GCCGACAATATCCGTTACGGCCGTGTCACAGCTGGGAATGATGAGGTGGAGGCTGCTGCT
CAGGCTGCAGGCATCCATGATGCCATTATGGCTTTCCCTGAAGGGTACAGGACACAGGTG
GGCGAGCGGGGACTGAAGCTGAGCGGCGGGGAGAAGCAGCGCGTCGCCATTGCCCGCACC
ATCCTCAAGGCTCCGGGCATCATTCTGCTGGATGAGGCAACGTCAGCGCTGGATACATCT
AATGAGAGGGCCATCCAGGCTTCTCTGGCCAAAGTCTGTGCCAACCGCACCACCATCGTA
GTGGCACACAGGCTCTCAACTGTGGTCAATGCTGACCAGATCCTCGTCATCAAGGATGGC
TGCATCGTGGAGAGGGGACGACACGAGGCTCTGTTGTCCCGAGGTGGGGTGTATGCTGAC
ATGTGGCAGCTGCAGCAGGGACAGGAAGAAACCTCTGAAGACACTAAGCCTCAGACCATG
GAACGGTGA

Protein Properties

Number of Residues

842

Molecular Weight

93884.7

Theoretical pI

8.61

Pfam Domain Function

ABC_tran (PF00005 )
ABC_membrane (PF00664 )

Signals

["None"]

Transmembrane Regions

["27-47", "73-93", "107-127", "148-168", "186-206", "265-285", "376-396", "409-431", "502-522", "530-550"]

Protein Sequence

>ATP-binding cassette sub-family B member 6, mitochondrial
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGAD
SLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGAC
GLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADL
GQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWR
DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWN
SLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRW
HLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLC
MSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAI
IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQL
YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYA
DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQA
SLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV
GERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIV
VAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTM
ER

External Links

GenBank ID Protein

8547018

UniProtKB/Swiss-Prot ID

Q9NP58

UniProtKB/Swiss-Prot Entry Name

ABCB6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB039371

GeneCard ID