| Identification |
|---|
| HMDB Protein ID
| CDBP03822 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transportin-2 |
| Description
| Not Available |
| Synonyms
|
- Karyopherin beta-2b
|
| Gene Name
| TNPO2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus |
| GO Classification
|
| Function |
| binding |
| protein transporter activity |
| transporter activity |
| substrate-specific transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| TNPO2 |
| Gene Sequence
|
>2694 bp
ATGGACTGGCAGCCAGACGAGCAGGGCCTGCAGCAGGTCCTGCAGCTGCTCAAAGACTCA
CAGTCGCCCAACACAGCCACTCAGCGCATCGTGCAGGATAAACTCAAACAACTCAATCAG
TTTCCTGACTTCAACAACTACCTGATTTTCGTCCTGACCAGACTCAAGTCAGAAGATGAG
CCAACGCGCTCTCTCAGTGGCCTCATCCTCAAGAACAACGTGAAGGCACACTATCAGAGC
TTCCCACCCCCTGTGGCAGACTTCATCAAACAGGAGTGTCTCAACAACATTGGCGATGCC
TCCTCGCTCATCCGAGCCACCATTGGCATTCTCATCACCACCATCGCTTCCAAGGGTGAG
CTGCAGATGTGGCCCGAGCTGCTGCCCCAGCTCTGCAACCTGCTTAACTCGGAGGATTAC
AACACTTGTGAGGGAGCCTTTGGAGCCCTGCAGAAGATCTGTGAAGACTCATCAGAGCTT
CTGGACAGTGACGCCCTCAACAGGCCCCTCAACATCATGATCCCCAAGTTCCTGCAGTTC
TTCAAGCACTGCAGTCCCAAGATCCGGTCCCACGCCATCGCCTGCGTGAACCAGTTCATC
ATGGACCGGGCCCAGGCGCTGATGGACAATATTGACACCTTCATCGAGCACCTATTTGCC
CTGGCTGTGGATGATGACCCCGAGGTGCGGAAGAATGTGTGCCGTGCCCTGGTGATGCTT
CTGGAAGTGCGGATTGACAGGCTCATCCCCCACATGCACAGCATCATCCAGTACATGCTG
CAGAGGACCCAGGACCATGATGAGAACGTTGCCCTTGAGGCCTGTGAGTTCTGGCTGACG
CTGGCCGAGCAGCCCATCTGCAAGGAAGTCCTGGCCTCCCATCTGGTCCAGTTGATCCCC
ATCTTGGTGAATGGGATGAAGTACTCGGAAATTGACATCATCCTGCTCAAGGGGGATGTG
GAGGAGGATGAGGCTGTCCCCGACAGTGAGCAGGACATCAAGCCACGCTTCCACAAGTCA
CGCACGGTCACACTGCCCCACGAGGCTGAGCGGCCTGATGGCTCCGAGGACGCGGAGGAT
GACGATGATGATGATGCTCTGTCCGACTGGAATTTGAGGAAGTGCTCAGCGGCTGCACTG
GACGTCCTCGCCAATGTCTTCCGGGAGGAACTGCTGCCCCACCTACTCCCACTACTCAAA
GGCCTCCTCTTCCACCCCGAGTGGGTGGTCAAGGAGTCGGGCATCCTGGTGCTGGGCGCC
ATTGCTGAGGGCTGCATGCAGGGCATGGTGCCCTACCTGCCTGAGCTGATCCCGCACCTG
ATCCAGTGCCTGTCGGATAAGAAGGCCTTGGTCCGCTCCATCGCCTGCTGGACGCTGAGC
CGCTATGCCCACTGGGTGGTCAGCCAGCCACCCGACATGCACCTCAAGCCCCTGATGACA
GAGCTGCTCAAACGCATCCTGGATGGCAACAAGAGGGTACAGGAGGCGGCCTGCAGTGCT
TTTGCCACCCTGGAGGAAGAGGCCTGCACGGAGCTGGTGCCCTACCTCAGCTACATCCTG
GACACCCTTGTCTTTGCCTTTGGGAAATACCAGCACAAGAACCTGCTCATCCTCTATGAC
GCCATTGGCACCCTGGCCGACTCTGTAGGCCACCACCTCAACCAGCCGGAATACATCCAG
AAGCTGATGCCCCCACTGATCCAGAAGTGGAATGAGCTCAAGGACGAAGACAAGGACCTC
TTCCCCCTGCTGGAGTGTCTGTCATCGGTGGCCACCGCCCTGCAGAGTGGCTTCCTGCCT
TACTGTGAGCCCGTCTACCAGCGCTGTGTCACCCTGGTGCAGAAGACACTGGCTCAGGCC
ATGATGTACACCCAGCACCCTGAGCAGTATGAGGCTCCCGACAAGGACTTCATGATCGTA
GCACTGGATCTGCTCAGCGGCCTGGCCGAGGGCCTGGGTGGTCACGTGGAGCAGCTGGTG
GCCCGCAGCAACATCATGACATTGCTGTTCCAGTGCATGCAGGACTCGATGCCTGAGGTC
CGGCAGAGCTCCTTTGCCCTCCTGGGAGACCTCACCAAAGCCTGCTTCATCCATGTCAAG
CCCTGTATCGCCGAGTTCATGCCCATTCTGGGCACCAACCTGAACCCAGAGTTCATCTCC
GTCTGCAACAACGCCACCTGGGCCATTGGTGAAATCTGCATGCAGATGGGGGCAGAGATG
CAGCCTTATGTGCAGATGGTCCTCAACAACCTGGTGGAAATCATTAACCGACCCAACACA
CCCAAGACACTGCTGGAAAACACAGGTCGCCTGACGAGTCCCTCTGCCATTCCAGCCATC
ACCATCGGCCGCTTGGGCTACGTGTGCCCCCAGGAGGTGGCACCCATGCTGCAGCAGTTC
ATCCGGCCTTGGTGCACGTCCCTCAGGAACATCAGGGACAACGAGGAGAAGGACTCAGCC
TTCCGCGGCATCTGCATGATGATCGGTGTCAACCCGGGGGGCGTTGTGCAGGACTTTATT
TTCTTCTGCGATGCTGTAGCCTCCTGGGTGAGCCCGAAGGATGACCTTCGGGACATGTTT
TATAAGATTCTCCACGGCTTCAAAGACCAAGTTGGGGAAGATAACTGGCAGCAGTTCTCT
GAGCAATTCCCGCCGCTGCTCAAGGAGAGGCTGGCGGCTTTCTATGGGGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 897 |
| Molecular Weight
| 101387.1 |
| Theoretical pI
| 4.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transportin-2
MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDE
PTRSLSGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGE
LQMWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQF
FKHCSPKIRSHAIACVNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVML
LEVRIDRLIPHMHSIIQYMLQRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIP
ILVNGMKYSEIDIILLKGDVEEDEAVPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAED
DDDDDALSDWNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGA
IAEGCMQGMVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYAHWVVSQPPDMHLKPLMT
ELLKRILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYD
AIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDKDLFPLLECLSSVATALQSGFLP
YCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALDLLSGLAEGLGGHVEQLV
ARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMPILGTNLNPEFIS
VCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTSPSAIPAI
TIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQDFI
FFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV
|
| External Links |
|---|
| GenBank ID Protein
| 209969838 |
| UniProtKB/Swiss-Prot ID
| O14787 |
| UniProtKB/Swiss-Prot Entry Name
| TNPO2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001136196.1 |
| GeneCard ID
| TNPO2 |
| GenAtlas ID
| TNPO2 |
| HGNC ID
| HGNC:19998 |
| References |
|---|
| General References
| Not Available |