| Identification |
|---|
| HMDB Protein ID
| CDBP03818 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tubulin-specific chaperone D |
| Description
| Not Available |
| Synonyms
|
- Beta-tubulin cofactor D
- SSD-1
- Tubulin-folding cofactor D
- tfcD
|
| Gene Name
| TBCD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB) |
| GO Classification
|
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q25.3 |
| SNPs
| TBCD |
| Gene Sequence
|
>3579 bp
ATGGCCCTGAGCGACGAACCGGCCGCGGGCGGCCCCGAGGAGGAGGCGGAGGACGAGACA
CTGGCCTTTGGCGCGGCGCTGGAAGCGTTCGGCGAGAGCGCGGAGACCCGGGCGCTGCTG
GGCCGCCTGCGGGAGGTGCACGGCGGCGGCGCGGAGCGCGAGGTGGCCCTGGAGCGGTTC
CGCGTAATAATGGACAAATACCAGGAGCAGCCTCATCTGTTGGACCCGCACCTTGAATGG
ATGATGAACTTGTTGTTGGACATAGTGCAAGATCAGACATCTCCAGCTTCCCTTGTACAT
CTGGCTTTTAAATTTCTTTACATCATCACCAAGGTTCGAGGCTATAAAACATTTCTTCGT
TTATTTCCTCATGAAGTTGCCGATGTAGAGCCTGTTTTAGATTTGGTCACAATTCAGAAT
CCCAAGGACCATGAAGCTTGGGAAACCCGCTACATGCTTTTGCTCTGGCTCTCCGTGACC
TGCCTGATCCCTTTTGATTTTTCTCGCCTTGACGGGAACCTCCTCACCCAGCCTGGGCAA
GCACGAATGTCCATAATGGACCGTATTCTCCAAATAGCAGAGTCCTACTTGATTGTCAGT
GACAAGGCCCGAGATGCAGCTGCTGTCCTTGTGTCCAGATTTATCACACGTCCTGATGTC
AAGCAAAGCAAGATGGCTGAGTTCCTGGACTGGAGCCTGTGCAATCTGGCCCGTTCCTCC
TTCCAGACCATGCAGGGGGTCATCACCATGGATGGGACGCTGCAGGCCCTGGCACAAATA
TTTAAACATGGAAAACGTGAAGACTGTTTGCCCTATGCTGCCACTGTCCTCAGGTGCCTC
GATGGCTGCAGACTCCCTGAGAGCAACCAGACCCTGCTGCGGAAGCTGGGGGTGAAGCTT
GTGCAGCGACTGGGGCTGACATTCCTGAAGCCGAAGGTGGCAGCATGGAGGTACCAGCGT
GGCTGCCGATCTTTGGCTGCAAATCTGCAGCTCCTCACTCAGGGTCAGAGTGAGCAGAAG
CCACTCATCCTGACCGAAGATGACGACGAAGATGACGACGTCCCAGAGGGGGTGGAGCGT
GTGATAGAGCAGCTGCTGGTCGGGCTGAAGGACAAGGACACGGTCGTGCGGTGGTCTGCA
GCCAAGGGCATCGGTAGGATGGCTGGCAGGCTTCCCAGAGCCCTGGCGGATGATGTGGTC
GGGTCTGTGCTGGACTGCTTCAGTTTCCAGGAGACTGACAAGGCGTGGCATGGGGGATGT
CTGGCGCTGGCAGAGCTGGGCAGGAGAGGCCTGTTGCTGCCGTCTCGACTCGTGGATGTT
GTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGC
ACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTT
GACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGA
CAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACG
CAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGA
GAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGG
TCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAAC
AGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTG
TGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATT
GATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATAT
TACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTAC
CTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCA
GTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAG
GCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACC
ACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATG
GATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCAC
GCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCC
CACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTAC
CACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCAC
TCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCC
GTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACC
ACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAG
TTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGT
TTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT
GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGG
GACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTA
CCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1192 |
| Molecular Weight
| 132598.5 |
| Theoretical pI
| 6.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tubulin-specific chaperone D
MALSDEPAAGGPEEEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERF
RVIMDKYQEQPHLLDPHLEWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLR
LFPHEVADVEPVLDLVTIQNPKDHEAWETRYMLLLWLSVTCLIPFDFSRLDGNLLTQPGQ
ARMSIMDRILQIAESYLIVSDKARDAAAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSS
FQTMQGVITMDGTLQALAQIFKHGKREDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKL
VQRLGLTFLKPKVAAWRYQRGCRSLAANLQLLTQGQSEQKPLILTEDDDEDDDVPEGVER
VIEQLLVGLKDKDTVVRWSAAKGIGRMAGRLPRALADDVVGSVLDCFSFQETDKAWHGGC
LALAELGRRGLLLPSRLVDVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEP
QELKPFVTAISSALVIAAVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVG
NRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARALHNLAQQAPEFSAT
QVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQ
QLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSH
SRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNPEEMTRCGFSLALG
ALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAV
CGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCE
RIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWS
APSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALG
SFSGTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIK
NSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYS
DVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQLVPQPGAC
|
| External Links |
|---|
| GenBank ID Protein
| 41350333 |
| UniProtKB/Swiss-Prot ID
| Q9BTW9 |
| UniProtKB/Swiss-Prot Entry Name
| TBCD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005993.4 |
| GeneCard ID
| TBCD |
| GenAtlas ID
| TBCD |
| HGNC ID
| HGNC:11581 |
| References |
|---|
| General References
| Not Available |