Cannabis Compound Database: Showing Protein Synaptotagmin-like protein 2 (CDBP03803)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03803

Secondary Accession Numbers

Not Available

Name

Synaptotagmin-like protein 2

Description

Not Available

Synonyms

Breast cancer-associated antigen SGA-72M
Exophilin-4

Gene Name

SYTL2

Protein Type

Metal Binding

Biological Properties

General Function

Involved in Rab GTPase binding

Specific Function

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive

GO Classification

Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
rab gtpase binding
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
establishment of localization
transport
protein transport
intracellular protein transport

Cellular Location

Isoform 4:Cell membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11q14

SNPs

SYTL2

Gene Sequence

>2805 bp
ATGATTGACTTAAGCTTCCTGACTGAAGAGGAACAAGAGGCCATCATGAAGGTTTTGCAG
CGGGATGCTGCTCTGAAGAGGGCCGAAGAAGAGAGAGTCAGACATTTGCCTGAAAAAATT
AAGGATGACCAGCAGCTGAAGAATATGAGTGGCCAATGGTTTTATGAAGCCAAGGCAAAA
AGGCACAGGGACAAAATCCATGGCGCAGATATCATCAGAGCATCTATGAGAAAGAAGAGG
CCCCAGATAGCAGCTGAGCAGAGTAAAGACAGAGAAAATGGGGCAAAGGAAAGCTGGGTG
AATAATGTCAACAAAGATGCTTTCCTTCCTCCAGAGCTGGCTGGCGTTGTAGAAGAGCCA
GAAGAAGATGCAGCACCAGCAAGCCCGAGTTCCAGTGTGGTAAATCCAGCTTCCAGTGTG
ATTGATATGTCCCAGGAAAACACAAGGAAACCAAATGTGTCTCCAGAGAAGAGGAAGAAT
CCGTTTAATAGCTCCAAGTTGCCAGAAGGTCACTCATCACAACAAACTAAAAATGAACAG
TCAAAAAATGGAAGAACTGGTTTATTTCAGACTTCAAAAGAGGATGAATTGTCAGAGTCA
AAAGAAAAGTCAACTGTCGCAGATACTTCAATCCAAAAGTTAGAGAAATCAAAGCAGACT
TTGCCAGGCCTTTCAAATGGGTCCCAAATCAAGGCTCCAATCCCCAAAGCCAGGAAGATG
ATCTACAAATCAACTGATTTAAACAAAGATGATAACCAGTCTTTTCCTAGACAAAGGACA
GACTCCCTGAAAGCGAGAGGGGCTCCGAGAGGGATCCTCAAGCGCAACTCCAGTTCCAGT
AGCACAGACTCAGAAACCCTTCGTTATAATCACAACTTTGAACCCAAAAGCAAAATTGTG
TCACCTGGCCTAACCATCCATGAGAGAATTTCTGAGAAGGAGCATTCTTTAGAAGACAAC
TCTTCCCCAAACTCCCTGGAGCCATTAAAGCATGTGAGATTCTCTGCAGTGAAGGATGAG
CTTCCACAGAGTCCTGGGCTAATCCATGGTCGGGAAGTAGGAGAATTTAGTGTTTTAGAA
TCTGACAGATTGAAAAATGGAATGGAAGATGCAGGGGACACAGAAGAGTTTCAGAGTGAC
CCTAAGCCTTCTCAATACAGAAAGCCTTCGCTTTTTCATCAATCAACCTCAAGCCCATAT
GTATCAAAAAGTGAAACACATCAGCCAATGACTTCTGGTTCTTTTCCAATTAATGGGCTG
CATTCTCATTCAGAAGTTTTAACTGCAAGACCACAGTCTATGGAGAATTCACCAACCATC
AATGAACCCAAAGATAAATCATCAGAATTAACAAGGCTTGAATCTGTATTACCCAGAAGC
CCTGCTGATGAACTGTCTCATTGTGTTGAGCCTGAGCCATCTCAGGTGCCAGGTGGCAGT
TCTAGAGACCGTCAGCAAGGTTCAGAAGAAGAACCCAGTCCTGTTTTGAAAACTTTGGAA
AGGAGTGCCGCTAGGAAAATGCCTTCCAAAAGTCTAGAAGACATTTCATCAGATTCATCA
AATCAAGCAAAAGTAGATAATCAGCCAGAAGAATTAGTGCGTAGTGCTGAAGATGTTTCC
ACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGC
AAGTCTGTTCCAGCATTTCTCCAAGATGAGAGTGATGACAGAGAAACAGATACAGCATCA
GAAAGCAGTTACCAGCTCAGCAGACACAAGAAGAGCCCGAGCTCTTTAACCAATCTTAGC
AGCTCCTCTGGCATGACGTCCTTGTCTTCTGTGAGTGGCAGTGTGATGAGTGTTTATAGT
GGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAG
TCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTA
AAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATG
GGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTG
CGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCAT
CGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGG
GACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCA
CCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCA
GAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAA
TGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATC
CTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAAC
CCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCC
TGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTT
CGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACT
TCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCA
ACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGA

Protein Properties

Number of Residues

934

Molecular Weight

104929.0

Theoretical pI

8.21

Pfam Domain Function

C2 (PF00168 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Synaptotagmin-like protein 2
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK
RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEP
EEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQ
SKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKM
IYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIV
SPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLE
SDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGL
HSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGS
SRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVS
TVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLS
SSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADV
KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWH
RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVP
EPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTN
PIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDST
SEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK

External Links

GenBank ID Protein

244790013

UniProtKB/Swiss-Prot ID

Q9HCH5

UniProtKB/Swiss-Prot Entry Name

SYTL2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001162951.1

GeneCard ID