| Identification |
|---|
| HMDB Protein ID
| CDBP03802 |
| Secondary Accession Numbers
| Not Available |
| Name
| Synaptotagmin-like protein 1 |
| Description
| Not Available |
| Synonyms
|
- Exophilin-7
- Protein JFC1
|
| Gene Name
| SYTL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rab GTPase binding |
| Specific Function
| May play a role in vesicle trafficking. Binds phosphatidylinositol 3,4,5-triphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes |
| GO Classification
|
| Function |
| small gtpase regulator activity |
| enzyme regulator activity |
| rab gtpase binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.11 |
| SNPs
| SYTL1 |
| Gene Sequence
|
>1689 bp
ATGCCCCAGAGGGGCCACCCATCGCAAGAGGGGCTTTGGGCTCTGCCCTCCCTCCCCATG
GCGCATGGGCCAAAGCCTGAGACTGAAGGACTGTTGGACCTCAGCTTCCTGACAGAGGAG
GAGCAGGAGGCCATTGCTGGCGTCCTCCAACGAGATGCCCGCCTGCGCCAGCTGGAGGAG
GGGCGGGTCAGCAAGCTCCGGGCCTCAGTGGCAGACCCTGGGCAGCTGAAGATCCTGACA
GGGGACTGGTTCCAGGAAGCACGCTCCCAGCGGCACCACAATGCCCACTTCGGCTCTGAC
CTTGTCCGAGCGTCTATGCGCAGGAAGAAGAGCACCAGGGGAGACCAGGCTCCAGGCCAC
GACAGGGAGGCTGAGGCTGCTGTGAAAGAGAAGGAAGAGGGGCCAGAGCCCAGGCTCACC
ATTGATGAGGCCCCTCAGGAGAGGCTCAGGGAGACTGAGGGACCTGATTTCCCATCGCCT
TCTGTCCCCCTAAAGGCTTCAGATCCTGAGGAGGCGTCCCAGGCCCAGGAAGATCCTGGC
CAAGGAGACCAACAGGTCTGTGCCGAGGAGGCTGACCCGGAGCTGGAGCCCGCGTCGGGG
GGAGAGCAGGAGCCGCGGCCCCAGCAAGCCCAGACCAAGGCCGCGTCCCAGATCCTGGAG
AATGGGGAGGAGGCCCCGGGGCCCGACCCCTCTCTCGACCGCATGCTCAGCAGCAGCTCC
TCGGTGTCCAGCCTTAACTCCTCCACGCTGAGCGGCAGCCAGATGAGCCTGTCAGGCGAC
GCGGAGGCGGTGCAGGTCCGCGGCTCCGTGCACTTCGCGCTGCACTACGAGCCGGGCGCC
GCCGAGCTGCGCGTGCACGTGATCCAGTGCCAGGGCCTGGCCGCCGCCCGGCGCCGCCGC
TCGGACCCCTACGTCAAAAGCTACCTCCTCCCGGATAAGCAGAGCAAGCGCAAGACGGCG
GTGAAGAAACGGAATCTGAATCCGGTTTTCAACGAGACTCTCCGGTACTCCGTCCCGCAG
GCCGAGCTTCAGGGCCGCGTGCTGAGCCTGTCTGTGTGGCACCGCGAAAGCCTGGGTCGC
AACATCTTTCTGGGCGAAGTTGAAGTGCCCCTGGACACGTGGGACTGGGGCTCTGAGCCC
ACCTGGCTCCCCCTGCAGCCCCGGGTCCCACCCTCTCCCGACGACCTTCCGAGCCGCGGG
TTACTCGCCCTGTCCCTCAAGTACGTCCCCGCCGGCTCCGAGGGCGCAGGACTGCCCCCG
AGCGGGGAGCTGCACTTCTGGGTGAAGGAGGCTCGGGACCTCCTGCCGCTGCGGGCAGGA
TCCCTGGACACTTACGTACAATGCTTCGTGCTGCCTGATGACAGCCAGGCCAGCCGCCAG
CGTACAAGGGTTGTGCGACGCAGCCTCAGCCCTGTGTTCAATCACACCATGGTGTACGAT
GGCTTTGGGCCTGCTGACCTGCGCCAGGCTTGTGCCGAGCTCTCCCTCTGGGACCATGGG
GCCCTGGCCAACCGCCAGCTGGGGGGCACACGCCTCAGCCTGGGCACCGGCAGCAGCTAT
GGGCTGCAGGTGCCCTGGATGGATTCCACACCTGAGGAGAAGCAGCTGTGGCAAGCCCTC
CTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTACCCCTCAGAACCAACCTGGCCCCC
AGGACGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 562 |
| Molecular Weight
| 61856.5 |
| Theoretical pI
| 5.16 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synaptotagmin-like protein 1
MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE
GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH
DREAEAAVKEKEEGPEPRLTIDEAPQERLRETEGPDFPSPSVPLKASDPEEASQAQEDPG
QGDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENGEEAPGPDPSLDRMLSSSS
SVSSLNSSTLSGSQMSLSGDAEAVQVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRR
SDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHRESLGR
NIFLGEVEVPLDTWDWGSEPTWLPLQPRVPPSPDDLPSRGLLALSLKYVPAGSEGAGLPP
SGELHFWVKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYD
GFGPADLRQACAELSLWDHGALANRQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQAL
LEQPCEWVDGLLPLRTNLAPRT
|
| External Links |
|---|
| GenBank ID Protein
| 300863107 |
| UniProtKB/Swiss-Prot ID
| Q8IYJ3 |
| UniProtKB/Swiss-Prot Entry Name
| SYTL1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001193308.1 |
| GeneCard ID
| SYTL1 |
| GenAtlas ID
| SYTL1 |
| HGNC ID
| HGNC:15584 |
| References |
|---|
| General References
| Not Available |