| Identification |
|---|
| HMDB Protein ID
| CDBP03801 |
| Secondary Accession Numbers
| Not Available |
| Name
| Syntaxin-binding protein 1 |
| Description
| Not Available |
| Synonyms
|
- N-Sec1
- Protein unc-18 homolog 1
- Protein unc-18 homolog A
- Unc-18A
- Unc18-1
- p67
|
| Gene Name
| STXBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in vesicle docking involved in exocytosis |
| Specific Function
| May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions |
| GO Classification
|
| Process |
| establishment of localization |
| cellular process |
| transport |
| membrane docking |
| vesicle docking |
| vesicle docking involved in exocytosis |
| vesicle-mediated transport |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34.1 |
| SNPs
| STXBP1 |
| Gene Sequence
|
>1785 bp
ATGGCCCCCATTGGCCTCAAAGCTGTTGTCGGAGAGAAGATTATGCATGATGTGATAAAG
AAGGTCAAGAAGAAGGGGGAATGGAAGGTGCTGGTGGTGGATCAGTTAAGCATGAGGATG
CTGTCCTCCTGCTGCAAGATGACAGACATCATGACCGAGGGCATAACGATTGTGGAAGAT
ATCAATAAGCGCAGAGAGCCGCTCCCCAGCCTGGAGGCTGTGTATCTCATCACTCCATCC
GAGAAGTCCGTCCACTCTCTCATCAGTGACTTTAAGGACCCGCCGACTGCTAAATACCGG
GCTGCACACGTCTTCTTCACTGACTCTTGTCCAGATGCCCTGTTTAATGAACTGGTAAAA
TCCCGAGCAGCCAAAGTCATCAAAACTCTGACGGAAATCAATATTGCATTTCTCCCGTAT
GAATCCCAGGTCTATTCCTTGGACTCTGCTGACTCTTTCCAAAGCTTCTACAGTCCCCAC
AAGGCTCAGATGAAGAATCCTATACTGGAGCGCCTGGCAGAGCAGATCGCGACCCTTTGT
GCCACCCTGAAGGAGTACCCGGCTGTGCGGTATCGGGGGGAATACAAGGACAATGCCCTG
CTGGCTCAGCTAATCCAGGACAAGCTCGATGCCTATAAAGCTGATGATCCAACAATGGGG
GAGGGCCCAGACAAGGCACGCTCCCAGCTCCTGATCCTGGATCGAGGCTTTGACCCCAGC
TCCCCTGTGCTCCATGAATTGACTTTTCAGGCTATGAGTTATGATCTGCTGCCTATCGAA
AATGATGTATACAAGTATGAGACCAGCGGCATCGGGGAGGCACGGGTGAAGGAGGTGCTC
CTGGACGAGGACGACGACCTGTGGATAGCACTGCGCCACAAGCACATCGCAGAGGTGTCC
CAGGAAGTCACCCGGTCTCTGAAAGATTTTTCTTCTAGCAAGAGAATGAATACTGGAGAG
AAGACCACCATGCGGGACCTGTCCCAGATGCTGAAGAAGATGCCTCAGTACCAGAAAGAG
CTCAGCAAGTACTCCACCCACCTGCACCTTGCTGAGGACTGTATGAAGCATTACCAAGGC
ACCGTAGACAAACTCTGCCGAGTGGAGCAGGACCTGGCCATGGGCACAGATGCTGAGGGA
GAGAAGATCAAGGACCCTATGCGAGCCATCGTCCCCATTCTGCTGGATGCCAATGTCAGC
ACTTATGACAAAATCCGCATCATCCTTCTCTACATCTTTTTGAAGAATGGCATCACGGAG
GAAAACCTGAACAAACTGATCCAGCACGCCCAGATACCCCCGGAGGATAGTGAGATCATC
ACCAACATGGCTCACCTCGGCGTGCCCATCGTCACCGATTCCACGCTGCGTCGCCGGAGC
AAGCCGGAGCGGAAGGAACGCATCAGCGAGCAGACCTACCAGCTCTCACGGTGGACTCCG
ATTATCAAGGACATCATGGAGGACACTATTGAGGACAAACTTGACACCAAACACTACCCT
TATATCTCTACCCGTTCCTCTGCCTCCTTCAGCACCACCGCCGTCAGCGCCCGCTATGGG
CACTGGCATAAGAACAAGGCCCCAGGCGAGTACCGCAGTGGCCCCCGCCTCATCATTTTC
ATCCTTGGGGGTGTGAGCCTGAATGAGATGCGCTGCGCCTACGAGGTGACCCAGGCCAAC
GGAAAGTGGGAGGTGCTGATAGGATCCACACACATCCTCACCCCACAGAAACTGCTGGAC
ACACTGAAGAAACTGAATAAAACAGATGAAGAAATAAGCAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 594 |
| Molecular Weight
| 67568.0 |
| Theoretical pI
| 6.96 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Syntaxin-binding protein 1
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVED
INKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVK
SRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLC
ATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPS
SPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVS
QEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQG
TVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITE
ENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTP
IIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIF
ILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
|
| External Links |
|---|
| GenBank ID Protein
| 3041873 |
| UniProtKB/Swiss-Prot ID
| P61764 |
| UniProtKB/Swiss-Prot Entry Name
| STXB1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF004562 |
| GeneCard ID
| STXBP1 |
| GenAtlas ID
| STXBP1 |
| HGNC ID
| HGNC:11444 |
| References |
|---|
| General References
| Not Available |