| Identification |
|---|
| HMDB Protein ID
| CDBP03792 |
| Secondary Accession Numbers
| Not Available |
| Name
| Son of sevenless homolog 1 |
| Description
| Not Available |
| Synonyms
|
- SOS-1
|
| Gene Name
| SOS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Promotes the exchange of Ras-bound GDP by GTP |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| nucleic acid binding |
| dna binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| small gtpase regulator activity |
| binding |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fc Epsilon Receptor I Signaling in Mast Cells |    | Not Available | | Insulin Signalling |    | Not Available | | BCR-ABL Action in CML Pathogenesis |    | Not Available | | Imatinib Inhibition of BCR-ABL |    | Not Available | | Dasatinib Inhibition of BCR-ABL |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p21 |
| SNPs
| SOS1 |
| Gene Sequence
|
>4002 bp
ATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGG
GGACTACTGGTGCCTGCGCTGAAAAAGGTCCAGGGGCAAGTTCATCCTACTCTCGAGTCT
AATGATGATGCTCTTCAGTATGTTGAAGAATTAATTTTGCAATTATTAAATATGCTATGC
CAAGCTCAGCCCCGAAGTGCTTCAGATGTAGAGGAACGTGTTCAAAAAAGTTTCCCTCAT
CCAATTGATAAATGGGCAATAGCTGATGCCCAATCAGCTATTGAAAAGAGGAAGCGAAGA
AACCCTTTATCTCTCCCAGTAGAAAAAATTCATCCTTTATTAAAGGAGGTCCTAGGTTAT
AAAATTGACCACCAGGTTTCTGTTTACATAGTAGCAGTCTTAGAATACATTTCTGCAGAC
ATTTTAAAGCTGGTTGGGAATTATGTAAGAAATATACGGCATTATGAAATTACAAAACAA
GATATTAAAGTGGCAATGTGTGCTGACAAGGTATTGATGGATATGTTTCATCAAGATGTA
GAAGATATTAATATATTATCTTTAACTGACGAAGAGCCTTCCACCTCAGGAGAACAAACT
TACTATGATTTGGTAAAAGCATTTATGGCAGAAATTCGACAATATATAAGGGAACTAAAT
CTAATTATAAAAGTTTTTAGAGAGCCCTTTGTCTCCAATTCAAAATTGTTTTCAGCTAAT
GATGTAGAAAATATATTTAGTCGCATAGTAGATATACATGAACTTAGTGTAAAGTTACTG
GGCCATATAGAAGATACAGTAGAAATGACAGATGAAGGCAGTCCCCATCCACTAGTAGGA
AGCTGCTTTGAAGACTTAGCAGAGGAACTGGCATTTGATCCATATGAATCGTATGCTCGA
GATATTTTGCGACCTGGTTTTCATGATCGTTTCCTTAGTCAGTTATCAAAGCCTGGGGCA
GCACTTTATTTGCAGTCAATAGGCGAAGGTTTCAAAGAAGCTGTTCAATATGTTTTACCC
AGGCTGCTTCTGGCCCCTGTTTACCACTGTCTCCATTACTTTGAACTTTTGAAGCAGTTA
GAAGAAAAAAGTGAAGATCAAGAAGACAAGGAATGTTTAAAACAAGCAATAACAGCTTTG
CTTAATGTTCAGAGTGGTATGGAAAAAATATGTTCTAAAAGTCTTGCAAAACGAAGACTG
AGTGAATCTGCATGTCGGTTTTATAGTCAGCAAATGAAGGGGAAACAACTAGCAATCAAG
AAGATGAACGAGATTCAGAAGAATATTGATGGTTGGGAGGGAAAAGACATTGGACAGTGT
TGTAATGAATTTATAATGGAAGGAACTCTTACACGTGTAGGAGCCAAACATGAGAGACAC
ATATTTCTCTTTGATGGCTTAATGATTTGCTGTAAATCAAATCATGGGCAGCCAAGACTT
CCTGGTGCTAGCAATGCAGAATATCGTCTTAAAGAAAAGTTTTTTATGCGAAAGGTACAA
ATTAATGATAAAGATGACACCAATGAATACAAGCATGCTTTTGAAATAATTTTAAAAGAT
GAAAATAGTGTTATATTTTCTGCCAAGTCAGCTGAAGAGAAAAACAATTGGATGGCAGCA
TTGATATCTTTACAGTACCGGAGTACACTGGAAAGGATGCTTGATGTAACAATGCTACAG
GAAGAGAAAGAGGAGCAGATGAGGCTGCCTAGTGCTGATGTTTATAGATTTGCAGAGCCT
GACTCTGAAGAGAATATTATATTTGAAGAGAACATGCAGCCCAAGGCTGGAATTCCAATT
ATCAAAGCAGGAACTGTTATTAAACTTATAGAGAGGCTTACGTACCATATGTACGCAGAT
CCCAATTTTGTTCGGACATTTCTTACAACATACAGATCCTTTTGCAAACCTCAAGAACTA
CTGAGTCTTATAATAGAAAGGTTTGAAATTCCAGAGCCTGAGCCAACAGAAGCTGATCGC
ATAGCTATAGAGAATGGAGATCAACCCTTGAGTGCAGAACTGAAAAGATTTAGAAAAGAA
TATATACAGCCTGTGCAACTGCGAGTATTAAATGTATGTCGGCACTGGGTAGAGCACCAC
TTCTATGATTTTGAAAGAGATGCATATCTTTTGCAACGAATGGAAGAATTTATTGGAACA
GTAAGAGGTAAAGCAATGAAAAAATGGGTTGAATCCATCACTAAAATAATCCAAAGGAAA
AAAATTGCAAGAGACAATGGACCAGGTCATAATATTACATTTCAGAGTTCACCTCCCACA
GTTGAGTGGCATATAAGCAGACCTGGGCACATAGAGACTTTTGACCTGCTCACCTTACAC
CCAATAGAAATTGCTCGACAACTCACTTTACTTGAATCAGATCTATACCGAGCTGTACAG
CCATCAGAATTAGTTGGAAGTGTGTGGACAAAAGAAGACAAAGAAATTAACTCTCCTAAT
CTTCTGAAAATGATTCGACATACCACCAACCTCACTCTGTGGTTTGAGAAATGTATTGTA
GAAACTGAAAATTTAGAAGAAAGAGTAGCTGTGGTGAGTCGAATTATTGAGATTCTACAA
GTCTTTCAAGAGTTGAACAACTTTAATGGTGTCCTTGAGGTTGTCAGTGCTATGAATTCA
TCACCTGTTTACAGACTAGACCACACATTTGAGCAAATACCAAGTCGCCAGAAGAAAATT
TTAGAAGAAGCTCATGAATTGAGTGAAGATCACTATAAGAAATATTTGGCAAAACTCAGG
TCTATTAATCCGCCATGTGTGCCTTTCTTTGGAATTTATCTCACTAATATCTTGAAAACA
GAAGAAGGCAACCCTGAGGTCCTAAAAAGACATGGAAAAGAGCTTATAAACTTTAGCAAA
AGGAGGAAAGTAGCAGAAATAACAGGAGAGATCCAGCAGTACCAAAATCAGCCTTACTGT
TTACGAGTAGAATCAGATATCAAAAGGTTCTTTGAAAACTTGAATCCGATGGGAAATAGC
ATGGAGAAGGAATTTACAGATTATCTTTTCAACAAATCCCTAGAAATAGAACCACGAAAC
CCTAAGCCTCTCCCAAGATTTCCAAAAAAATATAGCTATCCCCTAAAATCTCCTGGTGTT
CGTCCATCAAACCCAAGACCAGGTACCATGAGGCATCCCACACCTCTGCAGCAGGAGCCA
AGGAAAATTAGTTATAGTAGGATCCCTGAAAGTGAAACAGAAAGTACAGCATCTGCACCA
AATTCTCCAAGAACACCGTTAACACCTCCGCCTGCTTCTGGTGCTTCCAGTACCACAGAT
GTTTGCAGTGTATTTGATTCCGATCATTCGAGCCCTTTTCACTCAAGCAATGATACCGTC
TTTATCCAAGTTACTCTGCCCCATGGCCCAAGATCTGCTTCTGTATCATCTATAAGTTTA
ACCAAAGGCACTGATGAAGTGCCTGTCCCTCCTCCTGTTCCTCCACGAAGACGACCAGAA
TCTGCCCCAGCAGAATCTTCACCATCTAAGATTATGTCTAAGCATTTGGACAGTCCCCCA
GCCATTCCTCCTAGGCAACCTACATCAAAAGCCTATTCACCACGATATTCAATATCAGAC
CGGACCTCTATCTCAGACCCTCCTGAAAGCCCTCCCTTATTACCACCACGAGAACCTGTG
AGGACACCTGATGTTTTCTCAAGCTCACCACTACATCTCCAACCTCCCCCTTTGGGCAAA
AAAAGTGACCATGGCAATGCCTTCTTCCCAAACAGCCCTTCCCCCTTTACACCACCTCCT
CCTCAAACACCTTCTCCTCACGGCACAAGAAGGCATCTGCCATCACCACCATTGACACAA
GAAGTGGACCTTCATTCCATTGCTGGGCCGCCTGTTCCTCCACGACAAAGCACTTCTCAA
CATATCCCTAAACTCCCTCCAAAAACTTACAAAAGGGAGCACACACACCCATCCATGCAC
AGAGATGGACCACCACTGTTGGAGAATGCCCATTCTTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1333 |
| Molecular Weight
| 152462.7 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Son of sevenless homolog 1
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
|
| External Links |
|---|
| GenBank ID Protein
| 158261479 |
| UniProtKB/Swiss-Prot ID
| Q07889 |
| UniProtKB/Swiss-Prot Entry Name
| SOS1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK290228 |
| GeneCard ID
| SOS1 |
| GenAtlas ID
| SOS1 |
| HGNC ID
| HGNC:11187 |
| References |
|---|
| General References
| Not Available |