| Identification |
|---|
| HMDB Protein ID
| CDBP03787 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein transport protein Sec16A |
| Description
| Not Available |
| Synonyms
|
- SEC16 homolog A
|
| Gene Name
| SEC16A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein transport |
| Specific Function
| Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Golgi apparatus membrane
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Peripheral membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q34.3 |
| SNPs
| SEC16A |
| Gene Sequence
|
>7074 bp
ATGCAGCCACCGCCCCAGACGGTCCCGTCTGGCATGGCTGGGCCACCTCCAGCCGGGAAT
CCTCGGAGCGTGTTCTGGGCTAGCAGCCCTTACAGGAGACGGGCTAATAATAATGCAGCA
GTGGCTCCGACAACTTGCCCGTTGCAGCCGGTCACGGATCCATTTGCTTTTAGTAGACAG
GCGCTCCAAAGTACACCACTGGGCAGTTCGTCCAAAAGCAGTCCACCTGTCTTGCAAGGC
CCAGCCCCCGCAGGGTTTTCTCAGCACCCCGGTTTGCTTGTTCCTCACACACATGCCAGA
GATAGCTCTCAGGGACCCTGTGAGCCCCTGCCTGGACCTCTGACACAGCCCAGAGCACAT
GCCAGTCCGTTTTCTGGTGCATTGACACCTTCAGCACCTCCTGGGCCTGAGATGAACAGG
AGTGCAGAGGTCGGTCCCAGTTCAGAGCCTGAAGTTCAGACTCTGCCATATCTTCCTCAC
TACATTCCAGGAGTGGATCCTGAAACGTCTCATGGGGGCCACCCTCATGGGAACATGCCT
GGGCTCGACCGACCCCTGAGCAGGCAAAACCCACATGACGGTGTGGTCACCCCAGCAGCA
TCCCCTTCCCTCCCTCAGCCTGGTCTGCAGATGCCAGGACAGTGGGGGCCAGTGCAGGGA
GGCCCACAGCCCTCGGGGCAACATCGTTCACCCTGCCCTGAAGGACCTGTTCCCAGCGGG
GTGCCCTGTGCCACCAGCGTTCCTCATTTCCCCACCCCGTCCATCCTACATCAGGGCCCT
GGTCATGAGCAACACAGCCCTCTGGTGGCTCCCCCAGCAGCCTTGCCCAGTGACGGAAGA
GACGAGGTGAGCCACTTGCAAAGTGGAAGCCACCTGGCCAATAACTCTGATCCTGAAAGT
ACATTCAGGCAAAATCCCAGAATTGTGAATCACTGGGCAAGCCCAGAGCTCAGGCAGAAT
CCAGGAGTGAAGAATGAGCACCGGCCCGCCTCTGCTCTTGTGAACCCCCTCGCCCGGGGA
GATAGCCCAGAAAACCGTACGCACCACCCACTGGGGGCTGGGGCCGGGTCTGGCTGTGCC
CCGCTAGAAGCAGACTCAGGAGCTTCAGGAGCTCTGGCGATGTTTTTCCAAGGGGGAGAG
ACAGAAAATGAGGAGAATCTCTCATCTGAAAAAGCAGGCTTATCTGGTCAAGCGGACTTT
GACGATTTCTGCTCCAGCCCTGGGCTAGGCCGTCCGCCCGCACCTACACACGTGGGGGCA
GGCAGCCTCTGCCAGGCCCTTCTCCCAGGCCCCAGCAATGAGGCTGCTGGTGATGTGTGG
GGTGACACAGCGAGCACAGGGGTGCCGGATGCCAGCGGCTCGCAGTATGAGAATGTTGAG
AACTTAGAATTTGTTCAGAATCAAGAAGTTCTGCCAAGTGAGCCCCTCAATTTGGACCCT
TCCTCCCCGAGTGACCAGTTCAGATATGGGCCCCTTCCTGGGCCAGCTGTGCCCAGGCAT
GGTGCTGTGTGCCACACCGGAGCCCCTGATGCCACACTGCATACAGTGCACCCTGACAGC
GTGTCATCCAGCTATAGCAGCAGAAGCCACGGAAGGCTCTCAGGCTCAGCCAGGCCCCAG
GAGCTGGTTGGCACATTCATTCAGCAAGAAGTTGGAAAACCCGAGGATGAAGCTTCAGGT
AGTTTTTTTAAGCAAATCGATTCTTCTCCCGTAGGAGGTGAAACAGACGAGACCACTGTG
AGCCAGAATTACCGTGGCAGCGTGTCCCAGCCCTCAACCCCGAGCCCCCCGAAACCTACA
GGAATATTTCAGACAAGTGCAAATAGTTCTTTCGAACCGGTAAAATCTCACTTAGTTGGG
GTAAAACCATTTGAGGCAGATCGCGCCAACGTGGTTGGTGAAGTAAGGGAGACCTGTGTC
CGCCAGAAGCAGTGCAGACCAGCTGCCGCCCTGCCCGATGCTTCCCCTGGCAACCTGGAG
CAGCCACCAGACAACATGGAGACCCTCTGTGCACCCCAGGTCTGTCCCCTGCCTCTTAAC
TCCACCACGGAAGCTGTGCACATGCTTCCGCACGCAGGGGCACCGCCCTTGGATACTGTG
TATCCAGCACCCGAGAAGAGGCCTTCAGCCAGGACCCAGGGGCCCGTGAAGTGTGAGAGC
CCAGCAACGACTCTGTGGGCGCAAAGTGAGCTGCCAGATTTTGGAGGCAACGTCCTTCTG
GCCCCTGCAGCCCCGGCGCTTTATGTGTGTGCAAAACCTCAGCCACCTGTTGTTCAGCCT
CCAGAAGAGGCGATGTCCGGGCAGCAGTCACGGAACCCAAGCTCGGCGGCCCCGGTGCAG
AGCCGAGGTGGCATTGGTGCTTCTGAGAACCTTGAGAATCCTCCCAAAATGGGAGAGGAG
GAGGCCCTTCAGTCCCAGGCGAGTTCTGGTTATGCAAGTTTATTATCCTCACCGCCCACT
GAGTCTCTGCAGAATCCTCCAGTCTTGATTGCTCAGCCTGATCACAGCTATAATCTGGCT
CAGCCCATTAACTTTTCTGTGTCCTTATCGAACTCTCATGAGAAGAATCAGTCCTGGAGA
GAGGCTTTGGTGGGGGATAGACCTGCAGTCAGCAGTTGGGCTCTCGGTGGTGATTCTGGG
GAGAACACTTCTTTGTCTGGGATTCCAACCAGCTCTGTCCTTAGCTTGTCTCTGCCTAGC
AGTGTTGCCCAAAGTAATTTTCCACAAGGTTCTGGTGCTTCCGAAATGGTTTCTAATCAG
CCTGCTAATTTGCTGGTTCAACCACCATCCCAGCCAGTTCCAGAGAACTTGGTTCCAGAA
AGTCAAAAGGATCGTAAGGCAGGAAGTGCTCTTCCCGGATTTGCTAATAGCCCTGCTGGA
AGCACAAGTGTGGTGTTAGTTCCACCTGCACACGGCACCCTGGTGCCTGATGGTAATAAG
GCAAACCATTCCAGTCATCAGGAAGACACTTACGGAGCCCTAGACTTTACCTTAAGCAGG
ACTTTGGAAAATCCTGTAAACGTGTACAACCCGTCCCATTCTGACAGCCTCGCTTCTCAG
CAAAGTGTTGCCAGTCATCCCAGACAATCTGGGCCTGGGGCGCCTAACCTTGACCGTTTT
TATCAGCAGGTCACGAAAGATGCCCAGGGCCAGCCTGGCCTCGAAAGAGCCCAGCAGGAG
CTGGTGCCACCCCAGCAACAGGCTTCTCCCCCACAACTACCCAAAGCCATGTTTTCGGAG
CTGTCAAATCCAGAAAGTCTGCCCGCACAGGGACAGGCCCAGAACTCAGCACAGTCACCA
GCAAGTCTGGTTCTGGTCGACGCGGGTCAGCAGCTGCCCCCTCGGCCTCCTCAGTCCTCT
AGCGTGTCTCTGGTGTCCAGTGGCTCCGGCCAGGCAGCTGTGCCGTCAGAGCAGCCGTGG
CCACAGCCAGTGCCTGCACTTGCCCCCGGCCCACCGCCTCAGGACCTGGCCGCCTACTAC
TACTACCGGCCTTTGTACGATGCCTACCAGCCTCAGTACTCTTTGCCGTACCCACCGGAG
CCTGGCGCAGCCTCCCTCTATTACCAGGATGTCTACAGCCTCTATGAGCCTCGATACAGG
CCCTATGATGGTGCTGCGTCTGCTTACGCCCAGAACTACCGCTATCCCGAGCCCGAGCGG
CCCAGCTCCCGAGCCAGCCACTCCTCGGAACGGCCACCTCCCAGGCAAGGATATCCTGAA
GGATACTATAGTTCCAAAAGTGGATGGAGCAGTCAGAGCGATTACTATGCAAGCTATTAC
TCCAGCCAGTACGATTATGGAGATCCAGGTCACTGGGATCGTTACCACTACAGTGCTAGA
GTCAGGGACCCCCGCACCTATGACCGGAGGTATTGGTGTGATGCAGAGTATGACGCATAC
AGGAGAGAGCACTCTGCCTTCGGGGACAGGCCCGAGAAACGTGACAACAACTGGAGGTAC
GATCCTCGCTTCACGGGGAGTTTTGACGATGACCCCGATCCGCACAGAGACCCTTATGGG
GAAGAGGTGGACCGGCGCAGCGTCCACAGCGAGCACTCGGCACGGAGCCTGCACAGCGCA
CACAGCCTGGCCAGCCGCCGCAGCAGCCTCAGCTCCCACTCGCACCAGAGTCAGATTTAC
AGAAGCCACAATGTGGCTGCCGGTTCCTACGAGGCCCCGCTTCCTCCAGGCTCCTTTCAC
GGCGATTTTGCCTACGGCACCTACCGCAGCAATTTCAGCAGTGGCCCCGGCTTCCCAGAG
TATGGCTACCCTGCCGACACCGTCTGGCCTGCCATGGAGCAAGTTTCATCAAGACCAACT
TCTCCTGAAAAATTTTCAGTGCCTCATGTCTGTGCCAGGTTTGGCCCTGGCGGTCAGCTT
ATCAAAGTGATTCCCAATCTGCCTTCAGAAGGACAGCCGGCCTTGGTGGAGGTCCACAGC
ATGGAGGCCTTGCTGCAGCACACGTCTGAGCAGGAGGAGATGCGGGCGTTCCCGGGACCC
CTGGCCAAAGACGACACCCATAAGGTGGATGTCATTAATTTTGCACAGAACAAAGCTATG
AAATGTTTGCAGAATGAAAACTTAATTGACAAAGAGTCTGCAAGTCTTCTTTGGAATTTT
ATTGTTCTCTTATGCAGACAAAATGGGACCGTGGTAGGGACCGACATTGCGGAGCTTCTG
TTACGAGACCACAGAACAGTGTGGCTTCCTGGGAAGTCGCCCAATGAAGCAAACCTGATT
GATTTCACGAATGAGGCAGTGGAGCAGGTGGAAGAGGAGGAGTCTGGTGAGGCCCAGCTC
TCTTTCCTCACTGGTGGTCCGGCGGCTGCCGCCAGCTCGCTCGAGAGAGAGACCGAGAGG
TTCAGGGAGCTGTTGCTGTATGGCCGTAAGAAGGATGCTTTGGAGTCTGCAATGAAGAAT
GGCCTGTGGGGTCACGCTCTGCTACTTGCAAGTAAGATGGACAGCCGGACACACGCCCGA
GTCATGACCAGGTTTGCTAACAGCCTCCCAATCAACGACCCTCTGCAGACAGTCTACCAG
CTCATGTCCGGACGGATGCCTGCCGCGTCCACGTGCTGTGGAGACGAGAAATGGGGAGAT
TGGAGGCCGCACCTCGCCATGGTCTTGTCCAACTTGAACAACAACATGGACGTCGAGTCC
AGGACGATGGCTACCATGGGCGACACTCTGGCTTCAAGGGGCCTCTTGGATGCGGCCCAC
TTCTGCTACCTCATGGCCCAGGCGGGATTTGGTGTTTACACGAAGAAAACTACAAAGCTT
GTCTTAATCGGATCCAATCACAGTTTGCCATTCTTAAAGTTCGCAACCAACGAAGCAATC
CAGAGGACGGAAGCCTATGAGTACGCCCAGTCCCTGGGTGCCGAGACCTGCCCCCTGCCT
AGTTTCCAGGTGTTTAAGTTCATCTACTCCTGCCGCCTGGCGGAAATGGGGCTGGCCACG
CAAGCCTTCCACTACTGTGAGGCCATCGCGAAGAGCATCCTGACGCAGCCGCACCTGTAT
TCCCCGGTGTTGATCAGCCAGCTTGTGCAGATGGCTTCCCAGTTACGACTCTTCGATCCC
CAGCTGAAAGAGAAGCCAGAAGAGGAGTCCTTGGCCGCACCCACGTGGCTGGTTCACCTG
CAGCAGGTGGAGCGGCAGATTAAGGAGGGGGCTGGAGTATGGCATCAGGATGGAGCCCTC
CCGCAGCAGTGTCCTGGCACTCCGAGTTCCGAGATGGAGCAGTTGGACAGGCCAGGACTC
AGTCAGCCAGGAGCCCTGGGGATCGCCAACCCTCTGCTGGCGGTGCCTGCACCGAGCCCT
GAGCACTCGAGCCCGAGCGTGCGGCTGCTGCCCTCAGCTCCGCAGACGCTCCCTGACGGC
CCATTGGCCAGTCCTGCCAGAGTGCCGATGTTCCCAGTGCCACTGCCCCCGGGGCCCCTG
GAGCCGGGTCCTGGCTGTGTGACCCCAGGGCCTGCACTTGGCTTCCTGGAGCCCTCCGGG
CCTGGCCTCCCACCTGGTGTGCCACCTCTGCAGGAAAGGAGACACTTGCTCCAGGAAGCC
AGGAGCCCAGACCCAGGGATAGTGCCGCAGGAGGCGCCTGTTGGAAACTCACTTTCCGAG
CTAAGCGAAGAAAATTTTGATGGAAAATTTGCTAATCTGACCCCCTCGAGGACGGTGCCA
GACTCGGAGGCCCCCCCAGGGTGGGATCGTGCCGACTCGGGTCCCACGCAGCCACCTCTG
TCTCTCTCACCCGCTCCCGAAACAAAGAGACCCGGACAGGCAGCCAAGAAAGAAACGAAG
GAACCTAAGAAGGGTGAATCCTGGTTCTTTCGTTGGCTACCTGGAAAGAAAAAGACAGAA
GCTTATTTGCCAGATGACAAGAACAAATCGATTGTTTGGGATGAAAAGAAAAACCAGTGG
GTGAATTTAAATGAGCCAGAAGAGGAGAAGAAAGCCCCGCCCCCACCTCCAACCTCGATG
CCCAAGACTGTGCAAGCTGCCCCGCCTGCCCTCCCAGGGCCTCCTGGAGCCCCCGTGAAC
ATGTACTCTAGAAGAGCAGCAGGAACCAGAGCTCGCTACGTTGACGTCCTGAACCCAAGC
GGGACCCAGCGGAGCGAGCCGGCTCTCGCTCCTGCGGACTTTGTCGCTCCACTCGCGCCA
CTCCCAATTCCTTCTAACTTGTTCGTGCCAACCCCAGATGCAGAAGAACCACAGCTTCCA
GACGGGACTGGCAGGGAAGGGCCTGCAGCAGCTAGGGGCCTGGCCAATCCAGAGCCTGCC
CCAGAGCCCAAGGTTTTAAGCTCTGCAGCGTCACTCCCTGGCTCTGAACTCCCCTCCTCC
AGGCCTGAGGGTTCCCAGGGAGGAGAGCTTTCGCGCTGTAGTTCAATGAGTTCATTATCA
CGTGAAGTGAGCCAGCATTTTAATCAGGCTCCTGGCGACCTCCCTGCTGCAGGGGGCCCT
CCCAGCGGGGCCATGCCCTTCTACAACCCTGCTCAGCTGGCACAGGCCTGCGCCACCTCC
GGGAGCTCAAGGCTAGGGAGGATTGGCCAGAGGAAGCACCTGGTGCTGAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 2179 |
| Molecular Weight
| 233515.1 |
| Theoretical pI
| 5.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protein transport protein Sec16A
MPGLDRPLSRQNPHDGVVTPAASPSLPQPGLQMPGQWGPVQGGPQPSGQHRSPCPEGPVP
SGVPCATSVPHFPTPSILHQGPGHEQHSPLVAPPAALPSDGRDEVSHLQSGSHLANNSDP
ESTFRQNPRIVNHWASPELRQNPGVKNEHRPASALVNPLARGDSPENRTHHPLGAGAGSG
CAPLEADSGASGALAMFFQGGETENEENLSSEKAGLSGQADFDDFCSSPGLGRPPAPTHV
GAGSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQYENVENLEFVQNQEVLPSEPLNL
DPSSPSDQFRYGPLPGPAVPRHGAVCHTGAPDATLHTVHPDSVSSSYSSRSHGRLSGSAR
PQELVGTFIQQEVGKPEDEASGSFFKQIDSSPVGGETDETTVSQNYRGSVSQPSTPSPPK
PTGIFQTSANSSFEPVKSHLVGVKPFEADRANVVGEVRETCVRQKQCRPAAALPDASPGN
LEQPPDNMETLCAPQVCPLPLNSTTEAVHMLPHAGAPPLDTVYPAPEKRPSARTQGPVKC
ESPATTLWAQSELPDFGGNVLLAPAAPALYVCAKPQPPVVQPPEEAMSGQQSRNPSSAAP
VQSRGGIGASENLENPPKMGEEEALQSQASSGYASLLSSPPTESLQNPPVLIAQPDHSYN
LAQPINFSVSLSNSHEKNQSWREALVGDRPAVSSWALGGDSGENTSLSGIPTSSVLSLSL
PSSVAQSNFPQGSGASEMVSNQPANLLVQPPSQPVPENLVPESQKDRKAGSALPGFANSP
AGSTSVVLVPPAHGTLVPDGNKANHSSHQEDTYGALDFTLSRTLENPVNVYNPSHSDSLA
SQQSVASHPRQSGPGAPNLDRFYQQVTKDAQGQPGLERAQQELVPPQQQASPPQLPKAMF
SELSNPESLPAQGQAQNSAQSPASLVLVDAGQQLPPRPPQSSSVSLVSSGSGQAAVPSEQ
PWPQPVPALAPGPPPQDLAAYYYYRPLYDAYQPQYSLPYPPEPGAASLYYQDVYSLYEPR
YRPYDGAASAYAQNYRYPEPERPSSRASHSSERPPPRQGYPEGYYSSKSGWSSQSDYYAS
YYSSQYDYGDPGHWDRYHYSARVRDPRTYDRRYWCDAEYDAYRREHSAFGDRPEKRDNNW
RYDPRFTGSFDDDPDPHRDPYGEEVDRRSVHSEHSARSLHSAHSLASRRSSLSSHSHQSQ
IYRSHNVAAGSYEAPLPPGSFHGDFAYGTYRSNFSSGPGFPEYGYPADTVWPAMEQVSSR
PTSPEKFSVPHVCARFGPGGQLIKVIPNLPSEGQPALVEVHSMEALLQHTSEQEEMRAFP
GPLAKDDTHKVDVINFAQNKAMKCLQNENLIDKESASLLWNFIVLLCRQNGTVVGTDIAE
LLLRDHRTVWLPGKSPNEANLIDFTNEAVEQVEEEESGEAQLSFLTGGPAAAASSLERET
ERFRELLLYGRKKDALESAMKNGLWGHALLLASKMDSRTHARVMTRFANSLPINDPLQTV
YQLMSGRMPAASTCCGDEKWGDWRPHLAMVLSNLNNNMDVESRTMATMGDTLASRGLLDA
AHFCYLMAQAGFGVYTKKTTKLVLIGSNHSLPFLKFATNEAIQRTEAYEYAQSLGAETCP
LPSFQVFKFIYSCRLAEMGLATQAFHYCEAIAKSILTQPHLYSPVLISQLVQMASQLRLF
DPQLKEKPEEESLAAPTWLVHLQQVERQIKEGAGVWHQDGALPQQCPGTPSSEMEQLDRP
GLSQPGALGIANPLLAVPAPSPEHSSPSVRLLPSAPQTLPDGPLASPARVPMFPVPLPPG
PLEPGPGCVTPGPALGFLEPSGPGLPPGVPPLQERRHLLQEARSPDPGIVPQEAPVGNSL
SELSEENFDGKFANLTPSRTVPDSEAPPGWDRADSGPTQPPLSLSPAPETKRPGQAAKKE
TKEPKKGESWFFRWLPGKKKTEAYLPDDKNKSIVWDEKKNQWVNLNEPEEEKKAPPPPPT
SMPKTVQAAPPALPGPPGAPVNMYSRRAAGTRARYVDVLNPSGTQRSEPALAPADFVAPL
APLPIPSNLFVPTPDAEEPQLPDGTGREGPAAARGLANPEPAPEPKVLSSAASLPGSELP
SSRPEGSQGGELSRCSSMSSLSREVSQHFNQAPGDLPAAGGPPSGAMPFYNPAQLAQACA
TSGSSRLGRIGQRKHLVLN
|
| External Links |
|---|
| GenBank ID Protein
| 124378039 |
| UniProtKB/Swiss-Prot ID
| O15027 |
| UniProtKB/Swiss-Prot Entry Name
| SC16A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| SEC16A |
| GenAtlas ID
| SEC16A |
| HGNC ID
| HGNC:29006 |
| References |
|---|
| General References
| Not Available |