| Identification |
|---|
| HMDB Protein ID
| CDBP03785 |
| Secondary Accession Numbers
| Not Available |
| Name
| GTP-binding protein SAR1a |
| Description
| Not Available |
| Synonyms
|
- COPII-associated small GTPase
|
| Gene Name
| SAR1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| Process |
| intracellular protein transport |
| establishment of localization |
| transport |
| protein transport |
|
| Cellular Location
|
- Golgi apparatus
- Endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q22.1 |
| SNPs
| SAR1A |
| Gene Sequence
|
>597 bp
ATGTCTTTCATCTTTGAGTGGATCTACAATGGCTTCAGCAGTGTGCTCCAGTTCCTAGGA
CTGTACAAGAAATCTGGAAAACTTGTATTCTTAGGTTTGGATAATGCAGGCAAAACCACT
CTTCTTCACATGCTCAAAGATGACAGATTGGGCCAACATGTTCCAACACTACATCCGACA
TCAGAAGAGCTAACAATTGCTGGAATGACCTTTACAACTTTTGATCTTGGTGGGCACGAG
CAAGCACGTCGCGTTTGGAAAAATTATCTCCCAGCAATTAATGGGATTGTCTTTCTGGTG
GACTGTGCAGATCATTCTCGCCTCGTGGAATCCAAAGTTGAGCTTAATGCTTTAATGACT
GATGAAACAATATCCAATGTGCCAATCCTTATCTTGGGTAACAAAATTGACAGAACAGAT
GCAATCAGTGAAGAAAAACTCCGTGAGATATTTGGGCTTTATGGACAGACCACAGGAAAG
GGGAATGTGACCCTGAAGGAGCTGAATGCTCGCCCCATGGAAGTGTTCATGTGCAGTGTG
CTCAAGAGGCAAGGTTACGGCGAGGGTTTCCGCTGGCTCTCCCAGTATATTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 198 |
| Molecular Weight
| 22366.6 |
| Theoretical pI
| 6.68 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GTP-binding protein SAR1a
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT
SEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMT
DETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSV
LKRQGYGEGFRWLSQYID
|
| External Links |
|---|
| GenBank ID Protein
| 8926205 |
| UniProtKB/Swiss-Prot ID
| Q9NR31 |
| UniProtKB/Swiss-Prot Entry Name
| SAR1A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF261717 |
| GeneCard ID
| SAR1A |
| GenAtlas ID
| SAR1A |
| HGNC ID
| HGNC:10534 |
| References |
|---|
| General References
| Not Available |