| Identification |
| HMDB Protein ID
| CDBP03783 |
| Secondary Accession Numbers
| Not Available |
| Name
| RUN and FYVE domain-containing protein 1 |
| Description
| Not Available |
| Synonyms
|
- FYVE-finger protein EIP1
- La-binding protein 1
- Rab4-interacting protein
- Zinc finger FYVE domain-containing protein 12
|
| Gene Name
| RUFY1 |
| Protein Type
| Metal Binding |
| Biological Properties |
| General Function
| Involved in zinc ion binding |
| Specific Function
| Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Early endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q35.3 |
| SNPs
| RUFY1 |
| Gene Sequence
|
>2127 bp
ATGGCCGACCGGGAAGGCGGCTGCGCTGCTGGGCGGGGGCGGGAGCTGGAGCCGGAGCTG
GAGCCGGGGCCGGGGCCCGGGTCAGCGCTTGAGCCGGGAGAAGAGTTTGAGATCGTGGAC
CGAAGCCAGCTGCCCGGCCCAGGCGACCTGCGGAGCGCAACGAGGCCGCGGGCGGCCGAG
GGCTGGTCGGCGCCCATCCTGACCCTGGCACGCAGGGCCACCGGGAACCTGTCGGCGAGC
TGCGGGAGCGCGCTGCGCGCGGCCGCGGGGCTGGGCGGCGGGGACAGCGGGGACGGCACG
GCGCGCGCAGCTTCTAAGTGCCAGATGATGGAGGAGCGTGCCAACCTGATGCACATGATG
AAACTCAGCATCAAGGTGTTGCTCCAGTCGGCTCTGAGCCTGGGCCGCAGCCTGGATGCG
GACCATGCCCCCTTGCAGCAGTTCTTTGTAGTGATGGAGCACTGCCTCAAACATGGGCTG
AAAGTTAAGAAGAGTTTTATTGGCCAAAATAAATCATTCTTTGGTCCTTTGGAGCTGGTG
GAGAAACTTTGTCCAGAAGCATCAGATATAGCGACTAGTGTCAGAAATCTTCCAGAATTA
AAGACAGCTGTGGGAAGAGGCCGAGCGTGGCTTTATCTTGCACTCATGCAAAAGAAACTG
GCAGATTATCTGAAAGTGCTTATAGACAATAAACATCTCTTAAGCGAGTTCTATGAGCCT
GAGGCTTTAATGATGGAGGAAGAAGGGATGGTGATTGTTGGTCTGCTGGTGGGACTCAAT
GTTCTCGATGCCAATCTCTGCTTGAAAGGAGAAGACTTGGATTCTCAGGTTGGAGTAATA
GATTTTTCCCTCTACCTTAAGGATGTGCAGGATCTTGATGGTGGCAAGGAGCATGAAAGA
ATTACTGATGTCCTTGATCAAAAAAATTATGTGGAAGAACTTAACCGGCACTTGAGCTGC
ACAGTTGGGGATCTTCAAACCAAGATAGATGGCTTGGAAAAGACTAACTCAAAGCTTCAA
GAAGAGCTTTCAGCTGCAACAGACCGAATTTGCTCACTTCAAGAAGAACAGCAGCAGTTA
AGAGAACAAAATGAATTAATTCGAGAAAGAAGTGAAAAGAGTGTAGAGATAACAAAACAG
GATACCAAAGTTGAGCTGGAGACTTACAAGCAAACTCGGCAAGGTCTGGATGAAATGTAC
AGTGATGTGTGGAAGCAGCTAAAAGAGGAGAAGAAAGTCCGGTTGGAACTGGAAAAAGAA
CTGGAGTTACAAATTGGAATGAAAACCGAAATGGAAATTGCAATGAAGTTACTGGAAAAG
GACACCCACGAGAAGCAGGACACACTAGTTGCCCTCCGCCAGCAGCTGGAAGAAGTCAAA
GCGATTAATTTACAGATGTTTCACAAAGCTCAGAATGCAGAGAGCAGTTTGCAGCAGAAG
AATGAAGCCATCACATCCTTTGAAGGAAAAACCAACCAAGTTATGTCCAGCATGAAACAA
ATGGAAGAAAGGTTGCAGCACTCGGAGCGGGCGAGGCAGGGGGCTGAGGAGCGGAGCCAC
AAGCTGCAGCAGGAGCTGGGCGGGAGGATCGGCGCCCTGCAGCTGCAGCTCTCCCAGCTG
CACGAGCAATGCTCAAGCCTGGAGAAAGAATTGAAATCAGAAAAAGAGCAAAGACAGGCT
CTTCAGCGCGAATTACAGCACGAGAAAGACACTTCCTCTCTACTCAGGATGGAGCTGCAA
CAAGTGGAAGGACTGAAAAAGGAGTTGCGGGAGCTTCAGGACGAGAAGGCAGAGCTGCAG
AAGATCTGCGAGGAGCAGGAACAAGCCCTCCAGGAAATGGGCCTGCACCTCAGCCAGTCC
AAGCTGAAGATGGAAGATATAAAAGAAGTGAACCAGGCACTGAAGGGCCACGCCTGGCTG
AAAGATGACGAAGCGACACACTGTAGGCAGTGTGAGAAGGAGTTCTCCATTTCCCGGAGA
AAGCACCACTGCCGGAACTGTGGCCACATCTTCTGCAACACCTGCTCCAGCAACGAGCTG
GCCCTGCCCTCCTACCCCAAGCCGGTGCGAGTGTGCGACAGCTGCCACACCCTGCTCCTG
CAGCGCTGCTCCTCCACGGCCTCCTGA
|
| Protein Properties |
| Number of Residues
| 708 |
| Molecular Weight
| 79817.2 |
| Theoretical pI
| 5.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>RUN and FYVE domain-containing protein 1
MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAE
GWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMM
KLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELV
EKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP
EALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHER
ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQL
REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE
LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK
NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL
HEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ
KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR
KHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
|
| External Links |
| GenBank ID Protein
| 94721336 |
| UniProtKB/Swiss-Prot ID
| Q96T51 |
| UniProtKB/Swiss-Prot Entry Name
| RUFY1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_025158.3 |
| GeneCard ID
| RUFY1 |
| GenAtlas ID
| RUFY1 |
| HGNC ID
| HGNC:19760 |
| References |
| General References
| Not Available |