| Identification |
|---|
| HMDB Protein ID
| CDBP03774 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphorylated adapter RNA export protein |
| Description
| Not Available |
| Synonyms
|
- RNA U small nuclear RNA export adapter protein
|
| Gene Name
| PHAX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in RNA binding |
| Specific Function
| A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Nucleus
- Cytoplasm
- nucleoplasm
- Cajal body
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q23.2 |
| SNPs
| PHAX |
| Gene Sequence
|
>1185 bp
ATGGCGTTGGAGGTCGGCGATATGGAAGATGGGCAGCTTTCCGACTCGGATTCCGACATG
ACGGTCGCACCCAGCGACAGGCCGCTGCAATTGCCAAAAGTGCTAGGTGGCGACAGTGCT
ATGAGGGCCTTCCAGAACACGGCAACTGCATGTGCACCAGTATCACATTATCGAGCTGTT
GAAAGTGTGGATTCAAGTGAAGAAAGTTTTTCTGATTCAGATGATGATAGCTGTCTTTGG
AAACGCAAACGACAGAAATGTTTTAACCCTCCTCCCAAACCAGAGCCTTTTCAGTTTGGC
CAGAGCAGTCAGAAACCACCTGTTGCTGGAGGAAAGAAGATTAACAACATATGGGGTGCT
GTGCTGCAGGAACAGAATCAAGATGCAGTGGCCACTGAACTTGGTATCTTGGGAATGGAG
GCCACTATTGACAGAAGCAGACAATCCGAGACCTACAATTATTTGCTTGCCAAGAAACTT
AGGAAGGAATCTCAAGAGCATACAAAAGATCTAGACAAGGAACTAGATGAATATATGCAT
GGTGGCAAAAAAATGGGATCAAAGGAAGAGGAAAATGGGCAAGGTCATCTCAAAAGGAAA
CGACCTGTCAAAGACAGGCTAGGGAACAGACCAGAAATGAACTATAAAGGTCGATACGAG
ATCACAGCGGAAGATTCTCAAGAGAAAGTGGCTGATGAAATTTCATTCAGGTTACAGGAA
CCAAAGAAAGACCTGATAGCCCGAGTAGTGAGGATTATTGGTAACAAAAAGGCAATTGAA
CTTCTGATGGAAACCGCTGAAGTTGAACAAAATGGTGGTCTCTTTATAATGAATGGTAGT
CGAAGAAGAACACCAGGTGGAGTTTTTCTGAATCTCTTGAAAAACACTCCTAGTATCAGC
GAGGAACAAATTAAGGACATTTTCTACATTGAAAACCAAAAGGAATATGAAAATAAAAAA
GCTGCTAGGAAGAGGAGAACACAAGTGTTGGGGAAAAAGATGAAACAAGCTATTAAAAGT
CTAAATTTTCAAGAAGCTGATGATACATCACGAGAAACTTTTGCAAGTGACACGAATGAG
GCCTTGGCCTCTCTTGATGAGTCACAGGAAGGACATGCAGAAGCCAAGTTGGAGGCAGAG
GAAGCCATTGAAGTTGATCATTCTCATGATTTGGACATCTTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 394 |
| Molecular Weight
| 44402.2 |
| Theoretical pI
| 5.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phosphorylated adapter RNA export protein
MALEVGDMEDGQLSDSDSDMTVAPSDRPLQLPKVLGGDSAMRAFQNTATACAPVSHYRAV
ESVDSSEESFSDSDDDSCLWKRKRQKCFNPPPKPEPFQFGQSSQKPPVAGGKKINNIWGA
VLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLRKESQEHTKDLDKELDEYMH
GGKKMGSKEEENGQGHLKRKRPVKDRLGNRPEMNYKGRYEITAEDSQEKVADEISFRLQE
PKKDLIARVVRIIGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSIS
EEQIKDIFYIENQKEYENKKAARKRRTQVLGKKMKQAIKSLNFQEDDDTSRETFASDTNE
ALASLDESQEGHAEAKLEAEEAIEVDHSHDLDIF
|
| External Links |
|---|
| GenBank ID Protein
| 10435105 |
| UniProtKB/Swiss-Prot ID
| Q9H814 |
| UniProtKB/Swiss-Prot Entry Name
| PHAX_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK023255 |
| GeneCard ID
| PHAX |
| GenAtlas ID
| PHAX |
| HGNC ID
| HGNC:10241 |
| References |
|---|
| General References
| Not Available |