| Identification |
|---|
| HMDB Protein ID
| CDBP03751 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras-related and estrogen-regulated growth inhibitor |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| RERG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential |
| GO Classification
|
| Component |
| membrane |
| cell part |
| intracellular |
| Function |
| pyrophosphatase activity |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p12.3 |
| SNPs
| RERG |
| Gene Sequence
|
>600 bp
ATGGCTAAAAGTGCGGAGGTCAAACTGGCAATATTTGGGAGAGCAGGCGTGGGCAAGTCA
GCTCTTGTAGTGAGATTTCTGACCAAACGGTTCATCTGGGAATATGATCCCACCCTCGAA
TCAACCTACCGACACCAAGCAACCATCGATGATGAAGTTGTTTCCATGGAGATACTAGAC
ACTGCTGGTCAGGAAGATACCATTCAGAGGGAGGGGCACATGCGATGGGGGGAAGGCTTT
GTGCTGGTCTACGACATTACTGACCGAGGAAGTTTTGAGGAAGTGCTGCCACTTAAGAAC
ATCCTAGATGAGATCAAAAAGCCCAAGAATGTGACTCTCATCTTGGTTGGAAACAAAGCT
GACTTGGACCACTCCAGGCAGGTTAGCACAGAAGAAGGAGAGAAGCTGGCCACAGAATTG
GCTTGTGCTTTTTACGAGTGCTCTGCCTGCACTGGAGAAGGGAACATCACAGAGATATTC
TATGAATTGTGTCGAGAGGTGCGTCGCCGGAGGATGGTGCAGGGCAAGACGAGGCGACGC
AGCTCCACCACGCATGTCAAGCAAGCCATTAACAAGATGCTCACCAAAATCAGTAGTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 199 |
| Molecular Weight
| 22607.7 |
| Theoretical pI
| 7.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-related and estrogen-regulated growth inhibitor
MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILD
TAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKA
DLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRR
SSTTHVKQAINKMLTKISS
|
| External Links |
|---|
| GenBank ID Protein
| 15430701 |
| UniProtKB/Swiss-Prot ID
| Q96A58 |
| UniProtKB/Swiss-Prot Entry Name
| RERG_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF339750 |
| GeneCard ID
| RERG |
| GenAtlas ID
| RERG |
| HGNC ID
| HGNC:15980 |
| References |
|---|
| General References
| Not Available |