| Identification |
|---|
| HMDB Protein ID
| CDBP03747 |
| Secondary Accession Numbers
| Not Available |
| Name
| Regulator of chromosome condensation |
| Description
| Not Available |
| Synonyms
|
- Cell cycle regulatory protein
- Chromosome condensation protein 1
|
| Gene Name
| RCC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone binding |
| Specific Function
| Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p36.1 |
| SNPs
| RCC1 |
| Gene Sequence
|
>1266 bp
ATGTCACCCAAGCGCATAGCTAAAAGAAGGTCCCCCCCAGCAGATGCCATCCCCAAAAGC
AAGAAGGTGAAGGTCTCACACAGGTCCCACAGCACAGAACCCGGCTTGGTGCTGACACTA
GGCCAGGGCGACGTGGGCCAGCTGGGGCTGGGTGAGAATGTGATGGAGAGGAAGAAGCCG
GCCCTGGTATCCATTCCGGAGGATGTTGTGCAGGCTGAGGCTGGGGGCATGCACACCGTG
TGTCTAAGCAAAAGTGGCCAGGTCTATTCCTTCGGCTGCAATGATGAGGGTGCCCTGGGA
AGGGACACATCAGTGGAGGGCTCGGAGATGGTCCCTGGGAAAGTGGAGCTGCAAGAGAAG
GTGGTACAGGTGTCAGCAGGAGACAGTCACACAGCAGCCCTCACCGATGATGGCCGTGTC
TTCCTCTGGGGCTCCTTCCGGGACAATAACGGTGTGATTGGACTGTTGGAGCCCATGAAG
AAGAGCATGGTGCCTGTGCAGGTGCAGCTGGATGTGCCTGTGGTAAAGGTGGCCTCAGGA
AACGACCACTTGGTGATGCTGACAGCTGATGGTGACCTCTACACCTTGGGCTGCGGGGAA
CAGGGCCAGCTAGGCCGTGTGCCTGAGTTATTTGCCAACCGTGGTGGCCGGCAAGGCCTC
GAACGACTCCTGGTCCCCAAGTGTGTGATGCTGAAATCCAGGGGAAGCCGGGGCCACGTG
AGATTCCAGGATGCCTTTTGTGGTGCCTATTTCACCTTTGCCATCTCCCATGAGGGCCAC
GTGTACGGCTTCGGCCTCTCCAACTACCATCAGCTTGGAACTCCGGGCACAGAATCTTGC
TTCATACCCCAGAACCTAACATCCTTCAAGAATTCCACCAAGTCCTGGGTGGGCTTCTCT
GGTGGCCAGCACCATACAGTCTGCATGGATTCGGAAGGAAAAGCATACAGCCTGGGCCGG
GCTGAGTATGGGCGGCTGGGCCTTGGAGAGGGTGCTGAGGAGAAGAGCATACCCACCCTC
ATCTCCAGGCTGCCTGCTGTCTCCTCGGTGGCTTGTGGGGCCTCTGTGGGGTATGCTGTG
ACCAAGGATGGTCGTGTTTTCGCCTGGGGCATGGGCACCAACTACCAGCTGGGCACAGGG
CAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTG
GTCTTATCTGTGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAG
AGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 421 |
| Molecular Weight
| 44968.9 |
| Theoretical pI
| 7.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Regulator of chromosome condensation
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
S
|
| External Links |
|---|
| GenBank ID Protein
| 20379024 |
| UniProtKB/Swiss-Prot ID
| P18754 |
| UniProtKB/Swiss-Prot Entry Name
| RCC1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF498924 |
| GeneCard ID
| RCC1 |
| GenAtlas ID
| RCC1 |
| HGNC ID
| HGNC:1913 |
| References |
|---|
| General References
| Not Available |