| Identification |
|---|
| HMDB Protein ID
| CDBP03744 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rabenosyn-5 |
| Description
| Not Available |
| Synonyms
|
- 110 kDa protein
- FYVE finger-containing Rab5 effector protein rabenosyn-5
- Zinc finger FYVE domain-containing protein 20
|
| Gene Name
| ZFYVE20 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- Lipid-anchor
- Cytoplasmic side
- Early endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p25.1 |
| SNPs
| ZFYVE20 |
| Gene Sequence
|
>2355 bp
ATGGCTTCTCTGGACGACCCAGGGGAAGTGAGGGAGGGCTTCCTCTGCCCTCTGTGCCTG
AAGGATCTGCAGTCTTTCTATCAGCTTCACTCACATTACGAGGAAGAACACTCAGGGGAA
GACCGTGATGTCAAAGGGCAAATTAAAAGTCTTGTCCAGAAGGCTAAAAAAGCAAAGGAC
AGGTTGTTGAAACGAGAAGGGGATGATCGAGCAGAGTCAGGGACCCAAGGATATGAGTCT
TTCAGCTATGGAGGGGTTGATCCTTACATGTGGGAACCCCAGGAGCTTGGTGCTGTGAGA
AGCCATCTTTCCGACTTCAAAAAACACCGAGCTGCTAGAATTGACCACTATGTTGTGGAA
GTCAATAAACTAATAATCAGGTTAGAGAAGCTCACTGCATTTGACAGAACAAATACTGAG
TCTGCAAAGATTCGAGCAATAGAAAAGTCTGTGGTGCCTTGGGTCAACGACCAGGATGTC
CCTTTCTGTCCAGACTGTGGGAATAAGTTCAGCATCCGGAACCGCCGCCACCACTGCCGC
CTCTGCGGGTCTATTATGTGCAAGAAGTGTATGGAGCTCATCAGCCTTCCCTTGGCAAAC
AAGCTCACCAGTGCCAGCAAGGAGTCCCTGAGCACCCACACCAGCCCCAGCCAGTCACCC
AACAGTGTCCATGGCTCCCGCCGAGGCAGCATCAGCAGCATGAGCAGTGTCAGCTCGGTC
CTGGATGAGAAGGACGATGACCGGATCCGCTGCTGTACACACTGCAAGGACACGCTGCTC
AAGAGAGAGCAGCAGATTGATGAGAAGGAGCACACACCTGACATCGTGAAGCTCTACGAG
AAATTACGACTTTGCATGGAGAAAGTTGACCAGAAAGCTCCAGAATACATCAGGATGGCA
GCATCATTAAATGCTGGGGAGACAACCTACAGTCTGGAACATGCCAGTGACCTTCGAGTG
GAAGTGCAGAAAGTGTATGAGCTGATAGACGCTTTAAGTAAGAAGATCTTAACCTTGGGC
TTGAACCAGGACCCTCCACCACATCCAAGCAATTTGCGGCTGCAGAGAATGATCAGATAC
TCAGCTACACTTTTTGTGCAGGAAAAGTTGCTTGGTTTGATGTCACTGCCAACCAAAGAA
CAGTTTGAGGAACTGAAAAAGAAAAGGAAGGAGGAAATGGAGAGGAAGAGGGCCGTGGAG
AGACAAGCTGCCCTGGAGTCCCAGCGAAGGCTTGAGGAAAGGCAGAGTGGCCTGGCTTCT
CGAGCGGCCAACGGGGAGGTGGCATCTCTCCGCAGGGGCCCTGCCCCCTTGAGAAAGGCT
GAGGGCTGGCTCCCACTGTCAGGAGGTCAGGGGCAGAGTGAGGACTCAGACCCGCTCCTC
CAGCAGATCCACAACATCACATCATTCATCAGGCAGGCCAAGGCCGCGGGCCGCATGGAT
GAAGTGCGCACTCTGCAGGAGAACCTGCGGCAGCTGCAGGACGAGTATGACCAGCAGCAG
ACAGAGAAGGCCATCGAGCTGTCCCGGAGGCAGGCTGAGGAGGAGGACCTGCAGCGGGAA
CAGCTGCAGATGTTGCGTGAACGGGAGTTGGAACGAGAAAGGGAGCAGTTTCGGGTGGCA
TCCCTGCACACACGGACTCGGTCCCTGGACTTCAGAGAAATCGGCCCTTTTCAGCTGGAG
CCCAGCAGAGAGCCTCGCACCCACCTTGCTTATGCTTTGGATCTAGGCTCTTCCCCAGTT
CCAAGCAGCACAGCTCCCAAGACCCCTTCACTTAGCTCAACTCAACCCACCAGAGTGTGG
TCTGGGCCCCCAGCCGTTGGCCAGGAGCGCTTACCCCAGAGCAGCATGCCACAGCAACAT
GAGGGGCCCTCCTTAAACCCCTTTGATGAGGAAGACCTCTCCAGCCCCATGGAAGAGGCC
ACTACTGGTCCTCCTGCTGCAGGGGTTTCCTTAGACCCTTCAGCCCGCATCCTGAAAGAG
TACAATCCTTTCGAGGAAGAGGACGAGGAGGAGGAAGCAGTGGCAGGGAATCCATTCATT
CAGCCAGACAGCCCAGCTCCTAACCCCTTCAGTGAGGAAGACGAACATCCCCAGCAGAGG
CTCTCAAGCCCTCTGGTTCCTGGTAACCCCTTTGAGGAACCCACCTGTATCAACCCCTTT
GAGATGGACAGTGACAGTGGGCCAGAGGCTGAGGAGCCCATAGAGGAAGAGCTCCTCCTG
CAGCAGATCGATAACATCAAGGCATACATCTTTGATGCCAAGCAGTGCGGCCGCCTGGAT
GAGGTAGAGGTGCTGACAGAGAATCTGCGGGAGCTGAAGCACACCCTGGCCAAGCAGAAG
GGGGGCACTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 784 |
| Molecular Weight
| 88868.8 |
| Theoretical pI
| 5.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rabenosyn-5
MASLDDPGEVREGFLCPLCLKDLQSFYQLHSHYEEEHSGEDRDVKGQIKSLVQKAKKAKD
RLLKREGDDRAESGTQGYESFSYGGVDPYMWEPQELGAVRSHLSDFKKHRAARIDHYVVE
VNKLIIRLEKLTAFDRTNTESAKIRAIEKSVVPWVNDQDVPFCPDCGNKFSIRNRRHHCR
LCGSIMCKKCMELISLPLANKLTSASKESLSTHTSPSQSPNSVHGSRRGSISSMSSVSSV
LDEKDDDRIRCCTHCKDTLLKREQQIDEKEHTPDIVKLYEKLRLCMEKVDQKAPEYIRMA
ASLNAGETTYSLEHASDLRVEVQKVYELIDALSKKILTLGLNQDPPPHPSNLRLQRMIRY
SATLFVQEKLLGLMSLPTKEQFEELKKKRKEEMERKRAVERQAALESQRRLEERQSGLAS
RAANGEVASLRRGPAPLRKAEGWLPLSGGQGQSEDSDPLLQQIHNITSFIRQAKAAGRMD
EVRTLQENLRQLQDEYDQQQTEKAIELSRRQAEEEDLQREQLQMLRERELEREREQFRVA
SLHTRTRSLDFREIGPFQLEPSREPRTHLAYALDLGSSPVPSSTAPKTPSLSSTQPTRVW
SGPPAVGQERLPQSSMPQQHEGPSLNPFDEEDLSSPMEEATTGPPAAGVSLDPSARILKE
YNPFEEEDEEEEAVAGNPFIQPDSPAPNPFSEEDEHPQQRLSSPLVPGNPFEEPTCINPF
EMDSDSGPEAEEPIEEELLLQQIDNIKAYIFDAKQCGRLDEVEVLTENLRELKHTLAKQK
GGTD
|
| External Links |
|---|
| GenBank ID Protein
| 70980547 |
| UniProtKB/Swiss-Prot ID
| Q9H1K0 |
| UniProtKB/Swiss-Prot Entry Name
| RBNS5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_022340.2 |
| GeneCard ID
| ZFYVE20 |
| GenAtlas ID
| ZFYVE20 |
| HGNC ID
| HGNC:20759 |
| References |
|---|
| General References
| Not Available |