| Identification |
|---|
| HMDB Protein ID
| CDBP03740 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab3 GTPase-activating protein catalytic subunit |
| Description
| Not Available |
| Synonyms
|
- RAB3 GTPase-activating protein 130 kDa subunit
- Rab3-GAP
- Rab3-GAP p130
|
| Gene Name
| RAB3GAP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Rab GTPase activator activity |
| Specific Function
| Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q21.3 |
| SNPs
| RAB3GAP1 |
| Gene Sequence
|
>2946 bp
ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCC
TCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATT
GGAAACTCTTTGGGAAAGCCACTCGAAAAGGGTATATTTACTTCTGGCACATGGGAAGAG
AAATCAGATGAAATTTCCTTTGCTGACTTCAAGTTCTCAGTCACTCATCATTATCTTGTA
CAAGAGTCCACTGATAAAGAAGGAAAGGATGAGTTATTAGAGGATGTTGTTCCACAATCT
ATGCAAGATTTGCTGGGTATGAATAATGACTTTCCTCCAAGAGCACATTGCCTGGTAAGA
TGGTATGGGCTACGTGAGTTCGTGGTGATTGCCCCTGCTGCACACAGTGACGCTGTTCTC
AGCGAATCTAAGTGCAACCTTCTTCTGAGTTCTGTTTCTATTGCCTTGGGAAACACTGGC
TGTCAGGTGCCACTCTTTGTGCAAATTCACCACAAATGGCGAAGAATGTATGTAGGAGAA
TGTCAAGGTCCTGGTGTACGAACTGATTTCGAAATGGTTCATCTTAGAAAAGTGCCAAAT
CAGTACACTCACTTATCAGGTCTGCTGGATATCTTCAAATCAAAGATTGGATGTCCTTTA
ACTCCATTGCCTCCAGTTAGTATTGCTATTCGATTTACCTATGTACTTCAAGATTGGCAG
CAGTATTTTTGGCCTCAGCAACCTCCAGACATAGATGCCCTTGTAGGAGGAGAAGTTGGA
GGCTTGGAGTTTGGCAAGTTACCATTTGGTGCCTGCGAAGATCCTATTAGTGAACTCCAT
TTAGCTACTACATGGCCTCATCTGACCGAAGGGATCATTGTGGATAATGATGTTTATTCT
GATTTGGATCCTATTCAAGCTCCACATTGGTCTGTTAGAGTTCGAAAAGCTGAGAATCCT
CAGTGTTTGCTAGGTGATTTTGTCACTGAATTTTTTAAAATTTGCCGTCGAAAGGAGTCA
ACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAGAAACTGCTGATATA
ACTCATGCTTTGTCAAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTT
TCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAGAGGTGTAGAGGAGTCA
CCGCTAAATAATGATGTTCTTAATACTATTCTCCTGTTCTTATTCCCTGATGCTGTTTCT
GAGAAACCATTAGATGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAA
GACTATAATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAGTTTAACATACAAACTG
GCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTC
TGGCAGGAATTTGTTCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGGA
TTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCAGAAACTACAGATGTTA
AATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGAT
GTCACTAATATATATCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAAT
CTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTGGGATTCCTGGAGTGAC
AGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAA
GAGAGTGGCAAGAAAGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTC
TATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCTCTACATTCCAGTAACC
CAGGAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAA
TTAGGTACATCGGCAGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTC
TCAGATATGGAGTCTTTTAAGGCAGCTAATCCAGGTTGCTCCCTGGAAGATTTTGTGAGG
TGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTG
CTGAAAGGAGAACTGAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGG
GAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTTTGATGATACACGGGAA
GCAGAAAAGGTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTG
TTACCTTGTGTGATTCATGCAGCTGTACTCAAGGTAAAGGAAGAAGAAAGTCTCGAAAAC
ATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTCCAGTAAAGTTTTGCAC
TTCCCCAATCCAGAAGACAAGAAATTGGAAGAAATCATTCACCAGATTACTAATGTGGAA
GCTCTCATTGCCAGAGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAG
GAGGAGGAAAAGGAAGATCTTGAAAGGTTTGTGAGTTGCCTGCTGGAGCAGCCTGAAGTG
TTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAAT
GCCCAGAGGGCTGCAGCTATGACTCCACCAGAGGAGGAATTGAAGAGAATGGGCTCCCCA
GAGGAAAGAAGGCAGAACTCCGTGTCAGACTTCCCACCCCCTGCTGGCCGGGAATTCATT
TTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAAGCTCTGCCTCAGCGGATGTAC
AGTGTTCTCACCAAAGAGGACTTTAGACTTGCAGGTGCCTTTTCATCAGATACTTCCTTC
TTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 981 |
| Molecular Weight
| 110522.6 |
| Theoretical pI
| 5.26 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab3 GTPase-activating protein catalytic subunit
MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEE
KSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVR
WYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGE
CQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQ
QYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYS
DLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADI
THALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVS
EKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHL
WQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD
VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQ
ESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAK
LGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVV
LKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHL
LPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVE
ALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVN
AQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMY
SVLTKEDFRLAGAFSSDTSFF
|
| External Links |
|---|
| GenBank ID Protein
| 55743118 |
| UniProtKB/Swiss-Prot ID
| Q15042 |
| UniProtKB/Swiss-Prot Entry Name
| RB3GP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_012233.2 |
| GeneCard ID
| RAB3GAP1 |
| GenAtlas ID
| RAB3GAP1 |
| HGNC ID
| HGNC:17063 |
| References |
|---|
| General References
| Not Available |